The DOI matches its Crossref record; 199 of the 199 references it cites were found in a registry or an index.
Nuclear speckles: molecular organization, biological function and role in disease
Open accessAbstract
The nucleoplasm is not homogenous; it consists of many types of nuclear bodies, also known as nuclear domains or nuclear subcompartments. These self-organizing structures gather machinery involved in various nuclear activities. Nuclear speckles (NSs) or splicing speckles, also called interchromatin granule clusters, were discovered as sites for splicing factor storage and modification. Further studies on transcription and mRNA maturation and export revealed a more general role for splicing speckles in RNA metabolism. Here, we discuss the functional implications of the localization of numerous proteins crucial for epigenetic regulation, chromatin organization, DNA repair and RNA modification to nuclear speckles. We highlight recent advances suggesting that NSs facilitate integrated regulation of gene expression. In addition, we consider the influence of abundant regulatory and signaling proteins, i.e. protein kinases and proteins involved in protein ubiquitination, phosphoinositide signaling and nucleoskeletal organization, on pre-mRNA synthesis and maturation. While many of these regulatory proteins act within NSs, direct evidence for mRNA metabolism events occurring in NSs is still lacking. NSs contribute to numerous human diseases, including cancers and viral infections. In addition, recent data have demonstrated close relationships between these structures and the development of neurological disorders.
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Cites
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“We thus screened the effect of 162 sgRNAs (targeting 54 genes) on the localizations of six RNA targets, including the lncRNA MALAT1, the U2 snRNA, and the noncoding RNA 7SK, all of which are known to localize to nuclear speckles (26, 27); the nascent preribosomal RNA and the noncoding RNA”
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Carnesecchi, J., Boumpas, P., van Nierop y Sanchez, P., Domsch, K., Pinto, H. D., Borges Pinto, P., & Lohmann, I. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkab1250 · Cited by 25
Metadata
- Authors
- Galganski, L., Urbanek, M. O., & Krzyzosiak, W. J.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-09-01
- Volume
- 45
- Issue
- 18
- Pages
- 10350-10368
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2753162941
- Cited by
- 499
- References
- 199
- FWCI
- 11.45
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
