The Spliceosome: Design Principles of a Dynamic RNP Machine

Intrinsically unstructured proteins and their functions

Dyson, H. J., & Wright, P. E. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1589 · Cited by 3,871 · see citing works

Mechanisms of Alternative Pre-Messenger RNA Splicing

Black, D. L. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161720 · Cited by 2,704 · see citing works

Listening to silence and understanding nonsense: exonic mutations that affect splicing

Cartegni, L., Chew, S. L., & Krainer, A. R. (2002) · Nature Reviews Genetics · doi:10.1038/nrg775 · Cited by 2,209 · see citing works

The RNA world

Gilbert, W. (1986) · Nature · Cited by 1,941 · see citing works

Spliceosome Structure and Function

Will, C. L., & Luhrmann, R. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003707 · Cited by 1,829 · see citing works

Structure of the 70S Ribosome Complexed with mRNA and tRNA

Selmer, M., Dunham, C., Murphy, F., Weixlbaumer, A., Petry, S., Kelley, A. C., Weir, J., & Ramakrishnan, V. (2006) · Science · doi:10.1126/science.1131127 · Cited by 1,352 · see citing works

Alternative splicing: increasing diversity in the proteomic world

Graveley, B. R. (2001) · Trends in Genetics · doi:10.1016/s0168-9525(00)02176-4 · Cited by 1,228 · see citing works

Recognition of Cognate Transfer RNA by the 30 <i>S</i> Ribosomal Subunit

Ogle, J. M., Brodersen, D. E., Clemons, W. M., Tarry, M. J., Carter, A. P., & Ramakrishnan, V. (2001) · Science · doi:10.1126/science.1060612 · Cited by 1,162 · see citing works

An extensive network of coupling among gene expression machines

Maniatis, T., & Reed, R. (2002) · Nature · doi:10.1038/416499a · Cited by 1,148 · see citing works

Mechanical Devices of the Spliceosome: Motors, Clocks, Springs, and Things

Staley, J. P., & Guthrie, C. (1998) · Cell · doi:10.1016/s0092-8674(00)80925-3 · Cited by 1,127 · see citing works

Alternative Splicing: New Insights from Global Analyses

Blencowe, B. J. (2006) · Cell · doi:10.1016/j.cell.2006.06.023 · Cited by 1,122 · see citing works

Exon Recognition in Vertebrate Splicing

Berget, S. M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.6.2411 · Cited by 1,090 · see citing works

Splicing in disease: disruption of the splicing code and the decoding machinery

Wang, G., & Cooper, T. A. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2164 · Cited by 1,040 · see citing works

Pre-mRNA Splicing

Jurica, M. S., & Moore, M. J. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00270-3 · Cited by 963 · see citing works

Large-Scale Proteomic Analysis of the Human SpliceosomePreprint

Rappsilber, J., Ryder, U., Lamond, A. I., & Mann, M. (2002) · Genome Research · doi:10.1101/gr.473902 · Cited by 945 · see citing works

Alternative pre-mRNA splicing: the logic of combinatorial control

Smith, C. W. J., & Valcárcel, J. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01604-2 · Cited by 901 · see citing works

Comprehensive proteomic analysis of the human spliceosome

Zhou, Z., Licklider, L. J., Gygi, S. P., & Reed, R. (2002) · Nature · doi:10.1038/nature01031 · Cited by 893 · see citing works

A ratchet-like inter-subunit reorganization of the ribosome during translocation

Frank, J., & Agrawal, R. K. (2000) · Nature · doi:10.1038/35018597 · Cited by 799 · see citing works

The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease

Lu, K. P., & Zhou, X. Z. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2261 · Cited by 682 · see citing works

Regulation of Alternative Splicing in Vivo by Overexpression of Antagonistic Splicing Factors

Cáceres, J. F., Stamm, S., Helfman, D. M., & Krainer, A. R. (1994) · Science · doi:10.1126/science.8085156 · Cited by 619 · see citing works

Structural Basis for RNA Unwinding by the DEAD-Box Protein Drosophila Vasa

Sengoku, T., Nureki, O., Nakamura, A., Kobayashi, S., & Yokoyama, S. (2006) · Cell · doi:10.1016/j.cell.2006.01.054 · Cited by 575 · see citing works

20 Splicing of Precursors to mRNAs by the Spliceosomes

Burge, C. B., Tuschl, T., & Sharp, P. A. (1999) · doi:10.1101/087969589.37.525 · Cited by 538 · see citing works

Translocation and Unwinding Mechanisms of RNA and DNA Helicases

Pyle, A. M. (2008) · Annual Review of Biophysics · doi:10.1146/annurev.biophys.37.032807.125908 · Cited by 519 · see citing works

Hydrolysis of GTP by elongation factor G drives tRNA movement on the ribosome

Rodnina, M. V., Savelsbergh, A., Katunin, V. I., & Wintermeyer, W. (1997) · Nature · doi:10.1038/385037a0 · Cited by 513 · see citing works

Crystal Structure of a Self-Spliced Group II Intron

Toor, N., Keating, K. S., Taylor, S. D., & Pyle, A. M. (2008) · Science · doi:10.1126/science.1153803 · Cited by 498 · see citing works

Splicing double: insights from the second spliceosome

Patel, A. A., & STEITZ, J. A. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1259 · Cited by 479 · see citing works

A structural understanding of the dynamic ribosome machine

Steitz, T. A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2352 · Cited by 449 · see citing works

A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome

Madhani, H. D., & Guthrie, C. (1992) · Cell · doi:10.1016/0092-8674(92)90556-r · Cited by 438 · see citing works

Genomewide Analysis of mRNA Processing in Yeast Using Splicing-Specific Microarrays

Clark, T. A., Sugnet, C. W., & Ares, M. (2002) · Science · doi:10.1126/science.1069415 · Cited by 411 · see citing works

Exon Identity Established through Differential Antagonism between Exonic Splicing Silencer-Bound hnRNP A1 and Enhancer-Bound SR Proteins

Zhu, J., Mayeda, A., & Krainer, A. R. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00409-9 · Cited by 396 · see citing works

Isolation of an active step I spliceosome and composition of its RNP core

Bessonov, S., Anokhina, M. M., Will, C. L., Urlaub, H., & Lührmann, R. (2008) · Nature · doi:10.1038/nature06842 · Cited by 390 · see citing works

Prp8 protein: At the heart of the spliceosome

Grainger, R. J. R., & Beggs, J. D. (2005) · RNA · doi:10.1261/rna.2220705 · Cited by 374 · see citing works

Small Nuclear Ribonucleoprotein Remodeling During Catalytic Activation of the Spliceosome

Makarov, E. M., Makarova, O. V., Urlaub, H., Gentzel, M., Will, C. L., Wilm, M. S., & Lührmann, R. (2002) · Science · doi:10.1126/science.1077783 · Cited by 374 · see citing works

Allosteric Cascade of Spliceosome Activation

Brow, D. A. (2002) · Annual Review of Genetics · doi:10.1146/annurev.genet.36.043002.091635 · Cited by 372 · see citing works

Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis

Jurica, M. S., Licklider, L. J., Gygi, S. P., Grigorieff, N., & Moore, M. J. (2002) · RNA · doi:10.1017/s1355838202021088 · Cited by 370 · see citing works

A doughnut‐shaped heteromer of human Sm‐like proteins binds to the 3′‐end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro

Achsel, T., Brahms, H., Kastner, B., et al. (1999) · The EMBO Journal · doi:10.1093/emboj/18.20.5789 · Cited by 337 · see citing works

The Prp19p-Associated Complex in Spliceosome Activation

Chan, S., Kao, D.-I., Tsai, W.-Y., & Cheng, S.-C. (2003) · Science · doi:10.1126/science.1086602 · Cited by 323 · see citing works

Protein composition of human prespliceosomes isolated by a tobramycin affinity-selection method

Hartmuth, K., Urlaub, H., Vornlocher, H., Will, C. L., Gentzel, M., Wilm, M. S., & Lührmann, R. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.262483899 · Cited by 302 · see citing works

Protein Composition and Electron Microscopy Structure of Affinity-Purified Human Spliceosomal B Complexes Isolated under Physiological Conditions

Deckert, J., Hartmuth, K., Boehringer, D., Behzadnia, N., Will, C. L., Kastner, B., Stark, H., Urlaub, H., & Lührmann, R. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00582-06 · Cited by 301 · see citing works

A Potential Role for U2AF-SAP 155 Interactions in Recruiting U2 snRNP to the Branch Site

Gozani, O., Potashkin, J. A., & Reed, R. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.8.4752 · Cited by 298 · see citing works

Identification of alternative splicing regulators by RNA interference in Drosophila

Park, J. W., Parisky, K. M., Celotto, A. M., Reenan, R. A., & Graveley, B. R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407004101 · Cited by 290 · see citing works

Interaction of U2AF 65 RS Region with Pre-mRNA of Branch Point and Promotion Base Pairing with U2 snRNA

Valcárcel, J., Gaur, R. K., Singh, R., & Green, M. R. (1996) · Science · doi:10.1126/science.273.5282.1706 · Cited by 288 · see citing works

RNA Structure and Function

Barciszewski, J. (2023) · RNA technologies · doi:10.1007/978-3-031-36390-0 · Cited by 283 · see citing works

Molecular Architecture of the Multiprotein Splicing Factor SF3b

Golas, M. M., Sander, B. O., Will, C. L., Lührmann, R., & Stark, H. (2003) · Science · doi:10.1126/science.1084155 · Cited by 277 · see citing works

The ever-increasing complexities of the exon junction complex

Tange, T. Ø., Nott, A., & Moore, M. J. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2004.03.012 · Cited by 274 · see citing works

Composition and Functional Characterization of the Yeast Spliceosomal Penta-snRNP

Stevens, S. W., Ryan, D. E., Ge, H. Y., Moore, R. E., Young, M. K., Lee, T. D., & Abelson, J. N. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00436-7 · Cited by 273 · see citing works

Metal-ion coordination by U6 small nuclear RNA contributes to catalysis in the spliceosome

Yean, S.-L., Wuenschell, G. E., Termini, J. S., & Lin, R.-J. (2000) · Nature · doi:10.1038/35048617 · Cited by 254 · see citing works

Prp43: An RNA helicase-like factor involved in spliceosome disassembly

Arenas, J. E., & Abelson, J. N. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.22.11798 · Cited by 253 · see citing works

Evidence that sequence-independent binding of highly conserved U2 snRNP proteins upstream of the branch site is required for assembly of spliceosomal complex A.Preprint

Gozani, O., Feld, R., & Reed, R. (1996) · Genes & Development · doi:10.1101/gad.10.2.233 · Cited by 250 · see citing works

RADIOLYTIC PROTEIN FOOTPRINTING WITH MASS SPECTROMETRY TO PROBE THE STRUCTURE OF MACROMOLECULAR COMPLEXES

Takamoto, K., & Chance, M. R. (2006) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.35.040405.102050 · Cited by 245 · see citing works

Characterization of Sm‐like proteins in yeast and their association with U6 snRNA

Mayes, A. E., Verdone, L., Legrain, P., & Beggs, J. D. (1999) · The EMBO Journal · doi:10.1093/emboj/18.15.4321 · Cited by 239 · see citing works

Building specificity with nonspecific RNA-binding proteins

Singh, R., & Valcárcel, J. (2005) · Nature Structural & Molecular Biology · doi:10.1038/nsmb961 · Cited by 222 · see citing works

Proteomics Analysis Reveals Stable Multiprotein Complexes in Both Fission and Budding Yeasts Containing Myb-Related Cdc5p/Cef1p, Novel Pre-mRNA Splicing Factors, and snRNAs

Ohi, M. D., Link, A. J., Ren, L., Jennings, J. L., McDonald, W. H., & Gould, K. L. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.7.2011-2024.2002 · Cited by 222 · see citing works

Splicing-related catalysis by protein-free snRNAs

Valadkhan, S., & Manley, J. L. (2001) · Nature · doi:10.1038/35099500 · Cited by 222 · see citing works

Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry

Ajuh, P., Küster, B., Panov, K., Zomerdijk, J. C. B. M., Mann, M., & Lamond, A. I. (2000) · The EMBO Journal · doi:10.1093/emboj/19.23.6569 · Cited by 219 · see citing works

Composition and three‐dimensional EM structure of double affinity‐purified, human prespliceosomal A complexes

Behzadnia, N., Golas, M. M., Hartmuth, K., Sander, B. O., Kastner, B., Deckert, J., Dube, P., Will, C. L., Urlaub, H., Stark, H., et al. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601631 · Cited by 218 · see citing works

An evolutionarily conserved U5 snRNP‐specific protein is a GTP‐binding factor closely related to the ribosomal translocase EF‐2

Fabrizio, P., Laggerbauer, B., Lauber, J., Lane, W. S., & Lührmann, R. (1997) · The EMBO Journal · doi:10.1093/emboj/16.13.4092 · Cited by 212 · see citing works

Integrating diverse data for structure determination of macromolecular assemblies

Alber, F., Förster, F., Korkin, D., Topf, M., & Sali, A. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.060407.135530 · Cited by 206 · see citing works

A conformational rearrangement in the spliceosome is dependent on PRP16 and ATP hydrolysis.

Schwer, B., & Guthrie, C. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05610.x · Cited by 203 · see citing works

Transcript Specificity in Yeast Pre-mRNA Splicing Revealed by Mutations in Core Spliceosomal Components

Pleiss, J. A., Whitworth, G. B., Bergkessel, M., & Guthrie, C. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050090 · Cited by 199 · see citing works

Molecular Movement inside the Translational Engine

Wilson, K. S., & Noller, H. F. (1998) · Cell · doi:10.1016/s0092-8674(00)80927-7 · Cited by 199 · see citing works

A subset of human 35S U5 proteins, including Prp19, function prior to catalytic step 1 of splicing

Makarova, O. V., Makarov, E. M., Urlaub, H., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600241 · Cited by 197 · see citing works

The network of protein–protein interactions within the human U4/U6.U5 tri-snRNP

Liu, S., Rauhut, R., Vornlocher, H., & Lührmann, R. (2006) · RNA · doi:10.1261/rna.55406 · Cited by 195 · see citing works

The EF-G-like GTPase Snu114p Regulates Spliceosome Dynamics Mediated by Brr2p, a DExD/H Box ATPase

Small, E. C., Leggett, S. R., Winans, A. A., & Staley, J. P. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.05.043 · Cited by 194 · see citing works

A novel U2-U6 snRNA structure is necessary for mammalian mRNA splicing.Preprint

Sun, J., & Manley, J. L. (1995) · Genes & Development · doi:10.1101/gad.9.7.843 · Cited by 193 · see citing works

Phosphorylation of spliceosomal protein SAP 155 coupled with splicing catalysisPreprint

Wang, C., Chua, K. F., Seghezzi, W., Lees, E. M., Gozani, O., & Reed, R. (1998) · Genes & Development · doi:10.1101/gad.12.10.1409 · Cited by 187 · see citing works

Functional interaction of a novel 15.5kD[U4/U6·U5] tri‐snRNP protein with the5′ stem–loop of U4 snRNA

Nottrott, S., Hartmuth, K., Fabrizio, P., Urlaub, H., Vidovic, I., Ficner, R., & Lührmann, R. (1999) · The EMBO Journal · doi:10.1093/emboj/18.21.6119 · Cited by 184 · see citing works

Exon ligation is proofread by the DExD/H-box ATPase Prp22p

Mayas, R. M., Maita, H., & Staley, J. P. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1093 · Cited by 183 · see citing works

A putative ATP binding protein influences the fidelity of branchpoint recognition in yeast splicing

Burgess, S. M., COUTO, J. R., & Guthrie, C. (1990) · Cell · doi:10.1016/0092-8674(90)90086-t · Cited by 182 · see citing works

Polypyrimidine tract binding protein controls the transition from exon definition to an intron defined spliceosome

Sharma, S., Kohlstaedt, L. A., Damianov, A., Rio, D. C., & Black, D. L. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1375 · Cited by 177 · see citing works

A novel U2 and U11/U12 snRNP protein that associates with the pre‐mRNA branch site

Will, C. L., Schneider, C., MacMillan, A. M., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.16.4536 · Cited by 176 · see citing works

RBM5/Luca-15/H37 Regulates Fas Alternative Splice Site Pairing after Exon Definition

Bonnal, S., Martínez, C., Förch, P., Bachi, A., Wilm, M. S., & Valcárcel, J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.08.008 · Cited by 176 · see citing works

Conservation of the Protein Composition and Electron Microscopy Structure of Drosophila melanogaster and Human Spliceosomal Complexes

Herold, N., Will, C. L., Wolf, E., Kastner, B., Urlaub, H., & Lührmann, R. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01415-08 · Cited by 176 · see citing works

Spliceosome disassembly catalyzed by Prp43 and its associated components Ntr1 and Ntr2Preprint

Tsai, R.-T., Fu, R., Yeh, F.-L., Tseng, C. K., Lin, Y. J., Huang, Y.-H., & Cheng, S.-C. (2005) · Genes & Development · doi:10.1101/gad.1377405 · Cited by 173 · see citing works

The Ribosomal Peptidyl Transferase

Beringer, M., & Rodnina, M. V. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.03.015 · Cited by 172 · see citing works

Metal ion catalysis during splicing of premessenger RNA

Sontheimer, E. J., Sun, S., & Piccirilli, J. A. (1997) · Nature · doi:10.1038/42068 · Cited by 169 · see citing works

Proteomic analysis identifies a new complex required for nuclear pre‐mRNA retention and splicing

Dziembowski, A., Ventura, A.-P., Rutz, B., Caspary, F., Faux, C., Halgand, F., Laprévôte, O., & Séraphin, B. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600482 · Cited by 168 · see citing works

Structural dynamics of the ribosome

Korostelev, A. A., Ermolenko, D. N., & Noller, H. F. (2008) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2008.08.037 · Cited by 165 · see citing works

Splicing Regulation at the Second Catalytic Step by Sex-lethal Involves 3′ Splice Site Recognition by SPF45

Lallena, M. J., Chalmers, K. J., Llamazares, S., Lamond, A. I., & Valcárcel, J. (2002) · Cell · doi:10.1016/s0092-8674(02)00730-4 · Cited by 161 · see citing works

Spliceosome Activation by PRP2 ATPase prior to the First Transesterification Reaction of Pre-mRNA Splicing

Kim, S.-H., & Lin, R.-J. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.12.6810 · Cited by 155 · see citing works

“Nought May Endure but Mutability”: Spliceosome Dynamics and the Regulation of Splicing

Smith, D. J., Query, C. C., & Konarska, M. M. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.04.013 · Cited by 149 · see citing works

Binding of the Human Prp31 Nop Domain to a Composite RNA-Protein Platform in U4 snRNP

Liu, S., Li, P., Dybkov, O., Nottrott, S., Hartmuth, K., Lührmann, R., Carlomagno, T., & Wahl, M. C. (2007) · Science · doi:10.1126/science.1137924 · Cited by 149 · see citing works

The Human U5-220kD Protein (hPrp8) Forms a Stable RNA-Free Complex with Several U5-Specific Proteins, Including an RNA Unwindase, a Homologue of Ribosomal Elongation Factor EF-2, and a Novel WD-40 Protein

Achsel, T., Ahrens, K., Brahms, H., Teigelkamp, S., & Lührmann, R. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.11.6756 · Cited by 148 · see citing works

The second catalytic step of pre-mRNA splicing.

Umen, J., & Guthrie, C. (1995) · PubMed · Cited by 145 · see citing works

Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome

Mathew, R. S., Hartmuth, K., Möhlmann, S., Urlaub, H., Ficner, R., & Lührmann, R. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1415 · Cited by 145 · see citing works

Suppression of Multiple Substrate Mutations by Spliceosomal prp8 Alleles Suggests Functional Correlations with Ribosomal Ambiguity Mutants

Query, C. C., & Konarska, M. M. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00217-5 · Cited by 144 · see citing works

p68 RNA Helicase Is an Essential Human Splicing Factor That Acts at the U1 snRNA-5′ Splice Site Duplex

Liu, Z. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.15.5443-5450.2002 · Cited by 143 · see citing works

Control of Pre-mRNA Splicing by the General Splicing Factors PUF60 and U2AF65

Hastings, M. L., Allemand, E., Duelli, D. M., Myers, M. P., & Krainer, A. R. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000538 · Cited by 142 · see citing works

13 Spliceosome Structure and FunctionPreprint

Will, C. L., & Lührmann, R. (2006) · Cold Spring Harbor Monograph Archive · doi:10.1101/087969739.43.369 · Cited by 138 · see citing works

A Conformational Rearrangement in the Spliceosome Sets the Stage for Prp22-Dependent mRNA Release

Schwer, B. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.05.003 · Cited by 136 · see citing works

RNA-RNA Interactions in Nuclear Pre-mRNA SplicingPreprint

Nilsen, T. W. (1998) · Cold Spring Harbor Monograph Archive · doi:10.1101/087969509.35.279 · Cited by 135 · see citing works

A role for ubiquitin in the spliceosome assembly pathway

Bellare, P., Small, E. C., Huang, X., Wohlschlegel, J. A., Staley, J. P., & Sontheimer, E. J. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1401 · Cited by 134 · see citing works

Structure of a Multipartite Protein-Protein Interaction Domain in Splicing Factor Prp8 and Its Link to Retinitis Pigmentosa

Peña, V., Liu, S., Bujnicki, J. M., Lührmann, R., & Wahl, M. C. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.01.023 · Cited by 132 · see citing works

PP1/PP2A Phosphatases Are Required for the Second Step of Pre-mRNA Splicing and Target Specific snRNP Proteins

Shi, Y., Reddy, B. D., & Manley, J. L. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.07.022 · Cited by 130 · see citing works

Dynamic Regulation of Alternative Splicing by Silencers that Modulate 5′ Splice Site Competition

Yu, Y., Maroney, P. A., Denker, J. A., Zhang, X. H.-F., Dybkov, O., Lührmann, R., Jankowsky, E., Chasin, L. A., & Nilsen, T. W. (2008) · Cell · doi:10.1016/j.cell.2008.10.046 · Cited by 129 · see citing works

Competition between the ATPase Prp5 and Branch Region-U2 snRNA Pairing Modulates the Fidelity of Spliceosome Assembly

Xu, Y., & Query, C. C. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.09.022 · Cited by 129 · see citing works

ATP-dependent unwinding of U4/U6 snRNAs by the Brr2 helicase requires the C terminus of Prp8

Maeder, C., Kutach, A. K., & Guthrie, C. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1535 · Cited by 128 · see citing works

Mechanisms of elongation on the ribosome: dynamics of a macromolecular machine

Wintermeyer, W., Peske, F., Beringer, M., Gromadski, K. B., Savelsbergh, A., & Rodnina, M. V. (2004) · Biochemical Society Transactions · doi:10.1042/bst0320733 · Cited by 123 · see citing works

Repositioning of the Reaction Intermediate within the Catalytic Center of the Spliceosome

Konarska, M. M., Vilardell, J., & Query, C. C. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.01.017 · Cited by 120 · see citing works

A Single SR-like Protein, Npl3, Promotes Pre-mRNA Splicing in Budding Yeast

Kress, T. L., Krogan, N. J., & Guthrie, C. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.11.013 · Cited by 118 · see citing works

A cyclophilin functions in pre‐mRNA splicing

Horowitz, D. S., Lee, E. J., Mabon, S. A., & Misteli, T. (2002) · The EMBO Journal · doi:10.1093/emboj/21.3.470 · Cited by 116 · see citing works

Both Catalytic Steps of Nuclear Pre-mRNA Splicing Are Reversible

Tseng, C. K., & Cheng, S.-C. (2008) · Science · doi:10.1126/science.1158993 · Cited by 112 · see citing works

mRNA splicing and autocatalytic introns: Distant cousins or the products of chemical determinism?

Weiner, A. M. (1993) · Cell · doi:10.1016/0092-8674(93)90654-9 · Cited by 112 · see citing works

Structure and function of an RNase H domain at the heart of the spliceosome

Peña, V., Rozov, A., Fabrizio, P., Lührmann, R., & Wahl, M. C. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.209 · Cited by 101 · see citing works

The canonical GU dinucleotide at the 5' splice site is recognized by p220 of the U5 snRNP within the spliceosome.

Reyes, J. L., Koiš, P., Konforti, B. B., et al. (1996) · PubMed · Cited by 100 · see citing works

Spliceosomal cleavage generates the 3′ end of telomerase RNA

Box, J. A., Bunch, J. T., Tang, W., & Baumann, P. (2008) · Nature · doi:10.1038/nature07584 · Cited by 99 · see citing works

An exonic splicing silencer represses spliceosome assembly after ATP-dependent exon recognition

House, A. E., & Lynch, K. W. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1149 · Cited by 98 · see citing works

CRYO-ELECTRON MICROSCOPY OF SPLICEOSOMAL COMPONENTS

Stark, H., & Lührmann, R. (2006) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.35.040405.101953 · Cited by 97 · see citing works

Visualizing the splicing of single pre-mRNA molecules in whole cell extract

Crawford, D. J., Hoskins, A. A., Friedman, L. J., Gelles, J., & Moore, M. J. (2007) · RNA · doi:10.1261/rna.794808 · Cited by 97 · see citing works

Stalling of spliceosome assembly at distinct stages by small-molecule inhibitors of protein acetylation and deacetylation

Kuhn, A. N., van Santen, M. A., Schwienhorst, A., Urlaub, H., & Lührmann, R. (2008) · RNA · doi:10.1261/rna.1332609 · Cited by 95 · see citing works

The final stages of spliceosome maturation require Spp2p that can interact with the DEAH box protein Prp2p and promote step 1 of splicing.

Roy, J., Kim, K., Maddock, J. R., Anthony, J. G., & Woolford, J. L. (1995) · PubMed Central · Cited by 94 · see citing works

Biochemical and NMR analyses of an SF3b155–p14–U2AF-RNA interaction network involved in branch point definition during pre-mRNA splicing

Spadaccini, R., Reidt, U., Dybkov, O., Will, C. L., Frank, R., Stier, G., Corsini, L., Wahl, M. C., Lührmann, R., & Sattler, M. (2006) · RNA · doi:10.1261/rna.2271406 · Cited by 92 · see citing works

The ribosomal translocase homologue Snu114p is involved in unwinding U4/U6 RNA during activation of the spliceosome

Bartels, C., Klatt, C., Lührmann, R., & Fabrizio, P. (2002) · EMBO Reports · doi:10.1093/embo-reports/kvf172 · Cited by 88 · see citing works

Spliceosomal Small Nuclear Ribonucleoprotein Particles Repeatedly Cycle through Cajal Bodies

Staněk, D., Hnilicová, J., Novotný, I., Huranová, M., Blažíková, M., Wen, X., Sapra, A. K., & Neugebauer, K. M. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-12-1259 · Cited by 87 · see citing works

Functional and physical interactions between components of the Prp19p-associated complex

Chen, C. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.4.1029 · Cited by 86 · see citing works

Ubiquitin binding by a variant Jab1/MPN domain in the essential pre-mRNA splicing factor Prp8p

Bellare, P., Kutach, A. K., Rines, A. K., Guthrie, C., & Sontheimer, E. J. (2006) · RNA · doi:10.1261/rna.2152306 · Cited by 84 · see citing works

Protein Conformations, Interactions, and H/D Exchange

Maier, C. S., & Deinzer, M. L. (2005) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(05)02010-0 · Cited by 81 · see citing works

The splicing machinery is a genetic modifier of disease severity

Nissim‐Rafinia, M., & Kerem, B. (2005) · Trends in Genetics · doi:10.1016/j.tig.2005.07.005 · Cited by 79 · see citing works

Phosphorylation-dependent Interaction between the Splicing Factors SAP155 and NIPP1

Boudrez, A., Beullens, M., Waelkens, E., Stalmans, W., & Bollen, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204427200 · Cited by 79 · see citing works

Crystal structure of a core spliceosomal protein interface

Schellenberg, M. J., Edwards, R. A., Ritchie, D. B., Kent, O. A., Golas, M. M., Stark, H., Lührmann, R., Glover, J. N. M., & MacMillan, A. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508048103 · Cited by 75 · see citing works

Crystal structure of the β-finger domain of Prp8 reveals analogy to ribosomal proteins

Yang, K., Zhang, L., Xu, T., Heroux, A., & Zhao, R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805960105 · Cited by 75 · see citing works

Structural elucidation of a PRP8 core domain from the heart of the spliceosome

Ritchie, D. B., Schellenberg, M. J., Gesner, E. M., Raithatha, S. A., Stuart, D. T., & MacMillan, A. M. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1505 · Cited by 73 · see citing works

Multiple functions for the invariant AGC triad of U6 snRNA

Hilliker, A. K., & Staley, J. P. (2004) · RNA · doi:10.1261/rna.7310704 · Cited by 70 · see citing works

Insights into the mechanisms of splicing: more lessons from the ribosome: Figure 1.Preprint

Konarska, M. M., & Query, C. C. (2005) · Genes & Development · doi:10.1101/gad.1363105 · Cited by 70 · see citing works

Nuclear Inhibitor of Protein Phosphatase-1 (NIPP1) Directs Protein Phosphatase-1 (PP1) to Dephosphorylate the U2 Small Nuclear Ribonucleoprotein Particle (snRNP) Component, Spliceosome-associated Protein 155 (Sap155)

Tanuma, N., Kim, S.-E., Beullens, M., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805468200 · Cited by 59 · see citing works

Crystal structure of the C‐terminal domain of splicing factor Prp8 carrying retinitis pigmentosa mutants

Zhang, L., Shen, J., Guarnieri, M. T., Heroux, A., Yang, K., & Zhao, R. (2007) · Protein Science · doi:10.1110/ps.072872007 · Cited by 58 · see citing works

Proximity of conserved U6 and U2 snRNA elements to the 5′ splice site region in activated spliceosomes

Rhode, B. M., Hartmuth, K., Westhof, É., & Lührmann, R. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601134 · Cited by 56 · see citing works

Early organization of pre-mRNA during spliceosome assembly

Kent, O. A., & MacMillan, A. M. (2002) · Nature Structural Biology · doi:10.1038/nsb822 · Cited by 54 · see citing works

The 5′ End of U2 snRNA Is in Close Proximity to U1 and Functional Sites of the Pre-mRNA in Early Spliceosomal Complexes

Dönmez, G., Hartmuth, K., Kastner, B., Will, C. L., & Lührmann, R. (2007) · Molecular Cell · doi:10.1016/j.molcel.2006.12.019 · Cited by 53 · see citing works

Rapid peptide bond formation on isolated 50S ribosomal subunits

Wohlgemuth, I., Beringer, M., & Rodnina, M. V. (2006) · EMBO Reports · doi:10.1038/sj.embor.7400732 · Cited by 52 · see citing works

Crystal Structure of a Complex Between Human Spliceosomal Cyclophilin H and a U4/U6 snRNP-60K Peptide

Reidt, U., Wahl, M. C., Fasshauer, D., Horowitz, D. S., Lührmann, R., & Ficner, R. (2003) · Journal of Molecular Biology · doi:10.1016/s0022-2836(03)00684-3 · Cited by 51 · see citing works

Is the spliceosome a ribonucleoprotein enzyme?

Abelson, J. N. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1208-1235 · Cited by 47 · see citing works

The SF3b155 N-Terminal Domain Is a Scaffold Important for Splicing

Cass, D. M., & Berglund, J. A. (2006) · Biochemistry · doi:10.1021/bi060429o · Cited by 46 · see citing works

A simple principle to explain the evolution of pre-mRNA splicingPreprint

Izquierdo, J.-M., & Valcárcel, J. (2006) · Genes & Development · doi:10.1101/gad.1449106 · Cited by 39 · see citing works

The 100-kDa U5 snRNP protein (hPrp28p) contacts the 5′ splice site through its ATPase site

Ismaı̈li, N., SHA, M., Gustafson, E. H., et al. (2001) · RNA · doi:10.1017/s1355838201001807 · Cited by 37 · see citing works

Snt309p modulates interactions of Prp19p with its associated components to stabilize the Prp19p-associated complex essential for pre-mRNA splicing

Chen, H.-R., Tsao, T., Chen, C., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5406 · Cited by 35 · see citing works

Structure–function relationships in RNA and RNP enzymes: Recent advances

Hoogstraten, C. G., & Sumita, M. (2007) · Biopolymers · doi:10.1002/bip.20836 · Cited by 32 · see citing works

Enzymes Catalyzing Protein Folding and Their Cellular Functions

Nagradova, N. K. (2007) · Current Protein and Peptide Science · doi:10.2174/138920307780831866 · Cited by 27 · see citing works

Extending the Size of Protein–RNA Complexes Studied by Nuclear Magnetic Resonance Spectroscopy

Mackereth, C. D., Simon, B., & Sattler, M. (2005) · ChemBioChem · doi:10.1002/cbic.200500106 · Cited by 27 · see citing works

Cross-crystal averaging reveals that the structure of the peptidyl-transferase center is the same in the 70S ribosome and the 50S subunit

Simonović, M., & Steitz, T. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711076105 · Cited by 21 · see citing works

Searching for a wrench to throw into the splicing machine

Jurica, M. S. (2007) · Nature Chemical Biology · doi:10.1038/nchembio0108-3 · Cited by 18 · see citing works

Long non-coding RNAs: new players in cell differentiation and development

Fatica, A., & Bozzoni, I. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3606 · Cited by 2,980 · see citing works

Frequent pathway mutations of splicing machinery in myelodysplasia

Yoshida, K., Sanada, M., Shiraishi, Y., Nowak, D., Nagata, Y., Yamamoto, R., Sato, Y., Sato-Otsubo, A., Kon, A., Nagasaki, M., et al. (2011) · Nature · doi:10.1038/nature10496 · Cited by 2,029 · see citing works

Spliceosome Structure and Function

Will, C. L., & Luhrmann, R. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003707 · Cited by 1,829 · see citing works

Mechanisms and Regulation of Alternative Pre-mRNA Splicing

Lee, Y., & Rio, D. C. (2015) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060614-034316 · Cited by 1,291 · see citing works

Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches

Chen, M., & Manley, J. L. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2777 · Cited by 1,284 · see citing works

Intrinsically Disordered Proteins and Intrinsically Disordered Protein Regions

Oldfield, C. J., & Dunker, A. K. (2014) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-072711-164947 · Cited by 1,057 · see citing works

The Evolutionary Landscape of Alternative Splicing in Vertebrate Species

Barbosa-Morais, N. L., Irimia, M., Pan, Q., Xiong, H. Y., Gueroussov, S., Lee, L. J., Slobodeniuc, V., Kutter, C., Watt, S., Çolak, R., et al. (2012) · Science · doi:10.1126/science.1230612 · Cited by 1,063 · see citing works

Context-dependent control of alternative splicing by RNA-binding proteins

Fu, X.-D., & Ares, M. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3778 · Cited by 1,044 · see citing works

A Highly Conserved Program of Neuronal Microexons Is Misregulated in Autistic Brains

Irimia, M., Weatheritt, R. J., Ellis, J. D., Parikshak, N. N., Gonatopoulos-Pournatzis, T., Babor, M., Quesnel-Vallières, M., Tapial, J., Raj, B., O’Hanlon, D., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.035 · Cited by 693 · see citing works

Function of alternative splicing

Kelemen, O., Convertini, P., Zhang, Z., Wen, Y., Shen, M., Falaleeva, M., & Stamm, S. (2013) · Gene · doi:10.1016/j.gene.2012.07.083 · Cited by 743 · see citing works

Mammalian NET-Seq Reveals Genome-wide Nascent Transcription Coupled to RNA Processing

Nojima, T., Gomes, T., Grosso, A. R. F., Kimura, H., Dye, M. J., Dhir, S., Carmo-Fonseca, M., & Proudfoot, N. J. (2015) · Cell · doi:10.1016/j.cell.2015.03.027 · Cited by 562 · see citing works

Alternative splicing and nonsense-mediated decay modulate expression of important regulatory genes in Arabidopsis

Kalyna, M., Simpson, C. G., Syed, N. H., Lewandowska, D., Marquez, Y., Kusenda, B., Marshall, J., Fuller, J., Cardle, L., McNicol, J., et al. (2012) · Nucleic Acids Research · doi:10.1093/nar/gkr932 · Cited by 480 · see citing works

Dynamic integration of splicing within gene regulatory pathways

Braunschweig, U., Gueroussov, S., Plocik, A. M., Graveley, B. R., & Blencowe, B. J. (2013) · Cell · doi:10.1016/j.cell.2013.02.034 · Cited by 406 · see citing works

The neurogenetics of alternative splicing

Vuong, C. K., Black, D. L., & Zheng, S. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.27 · Cited by 340 · see citing works

Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing In Vivo

Shirai, C. L., Ley, J. N., White, B. S., Kim, S., Tibbitts, J., Shao, J., Ndonwi, M., Wadugu, B., Duncavage, E. J., Okeyo-Owuor, T., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.04.008 · Cited by 287 · see citing works

CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation

Krajewska, M., Dries, R., Grassetti, A. V., Dust, S., Gao, Y., Huang, H., Sharma, B., Day, D. S., Kwiatkowski, N., Pomaville, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09703-y · Cited by 281 · see citing works

Structure of a yeast activated spliceosome at 3.5 Å resolution

Yan, C., Wan, R., Bai, R., Huang, G., & Shi, Y. (2016) · Science · doi:10.1126/science.aag0291 · Cited by 261 · see citing works

The end of the message: multiple protein–RNA interactions define the mRNA polyadenylation site

Shi, Y., & Manley, J. L. (2015) · Genes &amp; Development · doi:10.1101/gad.261974.115 · Cited by 249 · see citing works

Structure and conformational dynamics of the human spliceosomal Bact complex

Haselbach, D., Komarov, I., Agafonov, D. E., Hartmuth, K., Graf, B., Dybkov, O., Urlaub, H., Kastner, B., Lührmann, R., & Stark, H. (2018) · Cell · doi:10.1016/j.cell.2018.01.010 · Cited by 218 · see citing works

Structural basis of splicing modulation by antitumor macrolide compounds

Cretu, C., Agrawal, A. A., Cook, A., Will, C. L., Fekkes, P., Smith, P. G., Lührmann, R., Larsen, N., Buonamici, S., & Pena, V. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.03.011 · Cited by 174 · see citing works

Alternative splicing: decoding an expansive regulatory layer

Irimia, M., & Blencowe, B. J. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.03.005 · Cited by 177 · see citing works

Splicing factor mutations and cancer

Yoshida, K., & Ogawa, S. (2014) · WIREs RNA · doi:10.1002/wrna.1222 · Cited by 155 · see citing works

Untitled work

van den Hoogenhof (2016) · doi:10.1161/circresaha.115.307872 · Cited by 134 · see citing works

Pre‐mRNA 3′‐end processing complex assembly and function

Chan, S., Choi, E., & Shi, Y. (2011) · WIREs RNA · doi:10.1002/wrna.54 · Cited by 147 · see citing works

Mutation of a U2 snRNA Gene Causes Global Disruption of Alternative Splicing and Neurodegeneration

Jia, Y., Mu, J. C., & Ackerman, S. L. (2012) · Cell · doi:10.1016/j.cell.2011.11.057 · Cited by 114 · see citing works

Regulation of constitutive and alternative mRNA splicing across the human transcriptome by PRPF8 is determined by 5′ splice site strength

Wickramasinghe, V. O., Gonzàlez-Porta, M., Perera, D., Bartolozzi, A. R., Sibley, C. R., Hallegger, M., Ule, J., Marioni, J. C., & Venkitaraman, A. R. (2015) · Genome Biology · doi:10.1186/s13059-015-0749-3 · Cited by 91 · see citing works

Whole Genome Analysis of Cyclin Dependent Kinase (CDK) Gene Family in Cotton and Functional Evaluation of the Role of CDKF4 Gene in Drought and Salt Stress Tolerance in Plants

Magwanga, R. O., Lu, P., Kirungu, J. N., Cai, X., Zhou, Z., Wang, X., Diouf, L., Xu, Y., Hou, Y., Hu, Y., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092625 · Cited by 88 · see citing works

Developments in RNA Splicing and Disease

Poulos, M. G., Batra, R., Charizanis, K., & Swanson, M. S. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000778 · Cited by 98 · see citing works

The RNA helicase Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes

De, I., Bessonov, S., Hofele, R., dos Santos, K., Will, C. L., Urlaub, H., Lührmann, R., & Pena, V. (2015) · Nature Structural &amp; Molecular Biology · doi:10.1038/nsmb.2951 · Cited by 89 · see citing works

Identification of a DNA Damage–Induced Alternative Splicing Pathway That Regulates p53 and Cellular Senescence Markers

Chen, J., Crutchley, J., Zhang, D., Owzar, K., & Kastan, M. B. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0908 · Cited by 93 · see citing works

From “Cellular” RNA to “Smart” RNA: Multiple Roles of RNA in Genome Stability and Beyond

Michelini, F., Jalihal, A. P., Francia, S., Meers, C., Neeb, Z. T., Rossiello, F., Gioia, U., Aguado, J., Jones-Weinert, C., Luke, B., et al. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00487 · Cited by 85 · see citing works

Aggregates of Small Nuclear Ribonucleic Acids ( <scp>snRNAs</scp> ) in <scp>A</scp> lzheimer's Disease

Hales, C. M., Dammer, E. B., Diner, I., Yi, H., Seyfried, N. T., Gearing, M., Glass, J. D., Montine, T. J., Levey, A. I., & Lah, J. J. (2014) · Brain Pathology · doi:10.1111/bpa.12133 · Cited by 89 · see citing works

A U1-U2 snRNP interaction network during intron definition

Shao, W., Kim, H.-S., Cao, Y., Xu, Y.-Z., & Query, C. C. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06234-11 · Cited by 85 · see citing works

A Splicing-Dependent Transcriptional Checkpoint Associated with Prespliceosome Formation

Chathoth, K. T., Barrass, J. D., Webb, S., & Beggs, J. D. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.01.017 · Cited by 84 · see citing works

Pre-mRNA processing factors meet the DNA damage response

Montecucco, A., & Biamonti, G. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00102 · Cited by 69 · see citing works

U1 small nuclear ribonucleoproteins (snRNPs) aggregate in Alzheimer’s disease due to autosomal dominant genetic mutations and trisomy 21

Hales, C. M., Seyfried, N. T., Dammer, E. B., Duong, D., Yi, H., Gearing, M., Troncoso, J. C., Mufson, E. J., Thambisetty, M., Levey, A. I., et al. (2014) · Molecular Neurodegeneration · doi:10.1186/1750-1326-9-15 · Cited by 58 · see citing works

Breast Cancer and the Other Non-Coding RNAs

Dvorská, D., Braný, D., Ňachajová, M., Halašová, E., & Danková, Z. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063280 · Cited by 38 · see citing works

Identification and characterization of a neuron-specific isoform of protrudin

Ohnishi, T., Shirane, M., Hashimoto, Y., Saita, S., & Nakayama, K. I. (2014) · Genes to Cells · doi:10.1111/gtc.12109 · Cited by 33 · see citing works

A functional link between lariat debranching enzyme and the intron-binding complex is defective in non-photosensitive trichothiodystrophy

Townley, B. A., Buerer, L., Tsao, N., Bacolla, A., Mansoori, F., Rusanov, T., Clark, N. E., Goodarzi, N., Schmidt, N., Srivatsan, S. N., et al. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.06.011 · Cited by 15 · see citing works

Spliceosome assembly involves the binding and release of U4 small nuclear ribonucleoprotein.

Lamond, A. I., Konarska, M. M., Grabowski, P. J., & Sharp, P. A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.2.411 · Cited by 178 · see citing works

The differential interaction of snRNPs with pre-mRNA reveals splicing kinetics in living cells

Huranová, M., Ivani, I., Benda, A., Poser, I., Brody, Y., Hof, M., Shav‐Tal, Y., Neugebauer, K. M., & Staněk, D. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201004030 · Cited by 103 · see citing works

Mammalian pre-mRNA splicing factors

Cáceres, J. F., & Krainer, A. R. (1997) · doi:10.1093/oso/9780199634187.003.0006 · Cited by 53 · see citing works

Ribonucleoprotein organization of eukaryotic RNA

Setyono, B., & Pederson, T. (1984) · Journal of Molecular Biology · doi:10.1016/0022-2836(84)90339-5 · Cited by 31 · see citing works

Identification of a functional mammalian spliceosome containing unspliced pre-mRNA.

Abmayr, S. M., Reed, R., & Maniatis, T. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.19.7216 · Cited by 75 · see citing works