Breast Cancer and the Other Non-Coding RNAs
Open accessAbstract
Breast cancer is very heterogenous and the most common gynaecological cancer, with various factors affecting its development. While its impact on human lives and national health budgets is still rising in almost all global areas, many molecular mechanisms affecting its onset and development remain unclear. Conventional treatments still prove inadequate in some aspects, and appropriate molecular therapeutic targets are required for improved outcomes. Recent scientific interest has therefore focused on the non-coding RNAs roles in tumour development and their potential as therapeutic targets. These RNAs comprise the majority of the human transcript and their broad action mechanisms range from gene silencing to chromatin remodelling. Many non-coding RNAs also have altered expression in breast cancer cell lines and tissues, and this is often connected with increased proliferation, a degraded extracellular environment, and higher endothelial to mesenchymal transition. Herein, we summarise the known abnormalities in the function and expression of long non-coding RNAs, Piwi interacting RNAs, small nucleolar RNAs and small nuclear RNAs in breast cancer, and how these abnormalities affect the development of this deadly disease. Finally, the use of RNA interference to suppress breast cancer growth is summarised.
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Nucleic acids (mRNA, miRNA, siRNA, piRNA, etc.) have been reported as a potential method for cancer treatment.
“In addition to proteins, nucleic acids (mRNA, miRNA, siRNA, piRNA, etc.) have also been reported as a potential method for cancer treatment [47,48].”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [48]
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Flagged first, then by citations
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The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System
Li, T., Li, X., Han, G., Liang, M., Yang, Z., Zhang, C., Huang, S., Tai, S., & Yu, S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics15010021 · Cited by 110 · see citing works
- Authors
- Dvorská, D., Braný, D., Ňachajová, M., Halašová, E., & Danková, Z.
- Affiliations
- Comenius University Bratislava (SK)
- Martin University Hospital (SK)
- Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 036 01 Martin, Slovakia
- Corresponding author
- Braný, Dušan
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2021-03-23
- Volume
- 22
- Issue
- 6
- Pages
- 3280
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC8005115
- OpenAlex
- W3137822748
- Cited by
- 38
- References
- 233
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 12 · 2023: 4 · 2022: 7 · 2021: 2
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Agentúra na Podporu Výskumu a Vývoja (APVV-16-0021)
- Operational Programme Integrated Infrastructure for the project: Integrative strategy in development of personalized medicine of selected malignant tumours and its impact on quality of life (ITMS: 313011V446)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Keywords
- breast cancer, non-coding RNA, long non-coding RNA, piRNA, small nucleolar RNA, small nuclear RNA, carcinogenesis, gene silencing, chromatin remodeling, endothelial-to-mesenchymal transition, RNA interference, therapeutic target
- MeSH terms
- Liquid Biopsy, Breast Neoplasms, Disease Susceptibility, Female, Humans, Biomarkers, Tumor, Gene Expression Regulation, Neoplastic, Disease Management, RNA, Untranslated, RNA Interference
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