Cited by 38Cancer-related molecular mechanisms researchMicroRNA in disease regulationRNA modifications and cancer

Breast Cancer and the Other Non-Coding RNAs

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Dvorská, Dana, Braný, Dušan, Ňachajová, Marcela, Halašová, Erika, Danková, Zuzana·2021·International Journal of Molecular Sciences

Abstract

Breast cancer is very heterogenous and the most common gynaecological cancer, with various factors affecting its development. While its impact on human lives and national health budgets is still rising in almost all global areas, many molecular mechanisms affecting its onset and development remain unclear. Conventional treatments still prove inadequate in some aspects, and appropriate molecular therapeutic targets are required for improved outcomes. Recent scientific interest has therefore focused on the non-coding RNAs roles in tumour development and their potential as therapeutic targets. These RNAs comprise the majority of the human transcript and their broad action mechanisms range from gene silencing to chromatin remodelling. Many non-coding RNAs also have altered expression in breast cancer cell lines and tissues, and this is often connected with increased proliferation, a degraded extracellular environment, and higher endothelial to mesenchymal transition. Herein, we summarise the known abnormalities in the function and expression of long non-coding RNAs, Piwi interacting RNAs, small nucleolar RNAs and small nuclear RNAs in breast cancer, and how these abnormalities affect the development of this deadly disease. Finally, the use of RNA interference to suppress breast cancer growth is summarised.

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Authors
Dvorská, D., Braný, D., Ňachajová, M., Halašová, E., & Danková, Z.
Affiliations
  • Comenius University Bratislava (SK)
  • Martin University Hospital (SK)
  • Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 036 01 Martin, Slovakia
Corresponding author
Braný, Dušan
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2021-03-23
Volume
22
Issue
6
Pages
3280
ISSN
1422-0067 (ISSN-L)
OpenAlex
W3137822748
Cited by
38
References
233
Citations by year
2026: 3 · 2025: 10 · 2024: 12 · 2023: 4 · 2022: 7 · 2021: 2
FWCI
0.75
Type
journal article
Language
en
Open access
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Agentúra na Podporu Výskumu a Vývoja (APVV-16-0021)
  • Operational Programme Integrated Infrastructure for the project: Integrative strategy in development of personalized medicine of selected malignant tumours and its impact on quality of life (ITMS: 313011V446)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
Keywords
breast cancer, non-coding RNA, long non-coding RNA, piRNA, small nucleolar RNA, small nuclear RNA, carcinogenesis, gene silencing, chromatin remodeling, endothelial-to-mesenchymal transition, RNA interference, therapeutic target
MeSH terms
Liquid Biopsy, Breast Neoplasms, Disease Susceptibility, Female, Humans, Biomarkers, Tumor, Gene Expression Regulation, Neoplastic, Disease Management, RNA, Untranslated, RNA Interference

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