Cited by 400Biomedical Text Mining and OntologiesGenomics and Phylogenetic StudiesBioinformatics and Genomic Networks

PubTator central: automated concept annotation for biomedical full text articles

Open access
Wei, Chih-Hsuan, Allot, Alexis, Leaman, Robert, Lu, Zhiyong·2019·Nucleic Acids Research

Abstract

PubTator Central (https://www.ncbi.nlm.nih.gov/research/pubtator/) is a web service for viewing and retrieving bioconcept annotations in full text biomedical articles. PubTator Central (PTC) provides automated annotations from state-of-the-art text mining systems for genes/proteins, genetic variants, diseases, chemicals, species and cell lines, all available for immediate download. PTC annotates PubMed (29 million abstracts) and the PMC Text Mining subset (3 million full text articles). The new PTC web interface allows users to build full text document collections and visualize concept annotations in each document. Annotations are downloadable in multiple formats (XML, JSON and tab delimited) via the online interface, a RESTful web service and bulk FTP. Improved concept identification systems and a new disambiguation module based on deep learning increase annotation accuracy, and the new server-side architecture is significantly faster. PTC is synchronized with PubMed and PubMed Central, with new articles added daily. The original PubTator service has served annotated abstracts for ∼300 million requests, enabling third-party research in use cases such as biocuration support, gene prioritization, genetic disease analysis, and literature-based knowledge discovery. We demonstrate the full text results in PTC significantly increase biomedical concept coverage and anticipate this expansion will both enhance existing downstream applications and enable new use cases.

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  1. Arighi,C., Hirschman,L., Lemberger,T., Bayer,S., Liechti,R., Comeau,D. and Wu,C. (2017) Bio-ID track overview. Proc. BioCreative Workshop, 482, 376.

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Authors
Wei, C.-H., Allot, A., Leaman, R., & Lu, Z.
Affiliations
National Institutes of Health (US)
Corresponding author
Lu, Zhiyong
Venue
Nucleic Acids Research
Published
2019-05-22
Volume
47
Issue
W1
Pages
W587-W593
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W2946690328
Cited by
400
References
52
Citations by year
2026: 19 · 2025: 40 · 2024: 74 · 2023: 77 · 2022: 76 · 2021: 60 · 2020: 45 · 2019: 8 · 2018: 1
FWCI
15.72
Type
journal article
Language
en
Open access
Licence
public-domain
Locations
  • Nucleic Acids Research (publishedVersion, public-domain)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
NIH
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biomedical Text Mining and Ontologies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
Keywords
biomedical text mining, full-text articles, genetic variant annotation, disease annotation, chemical annotation, concept disambiguation, deep learning, PubMed, PubMed Central, web services, biocuration, gene prioritization
MeSH terms
Cell Line, Disease, Genes, Humans, Proteins, Software, User-Computer Interface, Genetic Variation, PubMed, Data Mining, Data Curation

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