The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Hallmarks of ribosomopathies
Open accessAbstract
Ribosomopathies are diseases caused by defects in ribosomal constituents or in factors with a role in ribosome assembly. Intriguingly, congenital ribosomopathies display a paradoxical transition from early symptoms due to cellular hypo-proliferation to an elevated cancer risk later in life. Another association between ribosome defects and cancer came into view after the recent discovery of somatic mutations in ribosomal proteins and rDNA copy number changes in a variety of tumor types, giving rise to somatic ribosomopathies. Despite these clear connections between ribosome defects and cancer, the molecular mechanisms by which defects in this essential cellular machinery are oncogenic only start to emerge. In this review, the impact of ribosomal defects on the cellular function and their mechanisms of promoting oncogenesis are described. In particular, we discuss the emerging hallmarks of ribosomopathies such as the appearance of ‘onco-ribosomes’ that are specialized in translating oncoproteins, dysregulation of translation-independent extra-ribosomal functions of ribosomal proteins, rewired cellular protein and energy metabolism, and extensive oxidative stress leading to DNA damage. We end by integrating these findings in a model that can provide an explanation how ribosomopathies could lead to the transition from hypo- to hyper-proliferation in bone marrow failure syndromes with elevated cancer risk.
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Cites
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“Finally, reduced expression of RPS19, RPL5, RPL11 or RPS24 (eS24) in DBA cells leads to a specific decrease in GATA1 translation (78,79).”
Background
Cited by
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Specialized Ribosomes in Health and Disease
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Metadata
- Authors
- Kampen, K. R., Sulima, S. O., Vereecke, S., & De Keersmaecker, K.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2019-07-27
- Volume
- 48
- Issue
- 3
- Pages
- 1013-1028
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2966070481
- Cited by
- 214
- References
- 15
- FWCI
- 6.09
- Type
- journal article
- Language
- en
- Open access
- gold
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