The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Higher systemic inflammation is associated with poorer sleep quality in stable haemodialysis patients
Abstract
BACKGROUND: Increased inflammation has been noted in sleep disorder patients with normal renal function. However, the relationship between sleep quality and circulating inflammatory markers has not been previously studied in haemodialysis (HD) patients. METHODS: A total of 114 HD end-stage renal disease patients receiving maintenance HD for >3 months were included in this study. Pittsburgh Sleep Quality Index (PSQI) was used to measure individual's sleep quality. Based on the global PSQI score, patients were divided into groups of good sleepers (PSQI < 5) and bad sleepers (PSQI >or= 5). RESULTS: Twenty-three patients (20.2%) were classified as good sleepers and 91 patients (79.8%) were bad sleepers. Bad sleepers have significantly higher serum hsCRP level and lower serum phosphate level (all P < 0.05). The global PSQI score, or worse sleep quality are positively correlated with serum triglyceride level, high-sensitivity C-reactive protein (hsCRP) level, IL-1beta level and negatively correlated with the haemoglobin and phosphate level. In the multi-variable linear regression model, levels of hsCRP (beta = 0.209, P = 0.029) and triglyceride (beta = 0.212, P = 0.025) were both significant independent predictors for the global PSQI score. CONCLUSION: Our study demonstrated severe impairment of sleep quality in HD patients and corroborated the role of inflammation in the pathogenesis of sleep disturbance.
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“a longitudinal prediction of CRP levels by sleep disturbances in a general population was first demonstrated in a study including nearly 3,000 young adults”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [108]
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“a longitudinal study including nearly 3,000 participants reported that sleep disturbances (indexed by 6 components, such as sleep onset and sleep maintenance problems) predicted IL-6 levels measured 5 yr later”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [108]
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Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk
Meier-Ewert, H. K., Ridker, P. M., Rifai, N., Regan, M. M., Price, N. J., Dinges, D. F., & Mullington, J. M. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.07.050 · Cited by 1,195
Adverse Effects of Modest Sleep Restriction on Sleepiness, Performance, and Inflammatory Cytokines
Vgontzas, A. N., Zoumakis, E., Bixler, E. O., Lin, H.-M., Follett, H., Kales, A., & Chrousos, G. P. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031562 · Cited by 1,050
Stenvinkel, P., Ketteler, M., Johnson, R. J., Lindholm, B., Pecoits‐Filho, R., RIELLA, M. C., Heimbürger, O., Cederholm, T., & Girndt, M. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00200.x · Cited by 952
Castell, J. V., Gómez-Lechón, M. J., David, M., Fabra, R., Trullenque, R., & Heinrich, P. C. (1990) · Hepatology · doi:10.1002/hep.1840120517 · Cited by 759
Menon, V., Greene, T., Wang, X., Pereira, A. A., Marcovina, S. M., Beck, G. J., Kusek, J. W., Collins, A. J., Levey, A. S., & Sarnak, M. J. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00455.x · Cited by 418
Absence of diurnal variation of C-reactive protein concentrations in healthy human subjects
Meier-Ewert, H. K., Ridker, P. M., Rifai, N., Price, N., Dinges, D. F., & Mullington, J. M. (2001) · Clinical Chemistry · doi:10.1093/clinchem/47.3.426 · Cited by 410
Opp, M. R. (2005) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.01.002 · Cited by 393
Self-reported sleep quality is associated with the metabolic syndrome
Jennings, J. R., Muldoon, M. F., Hall, M., Buysse, D. J., & Manuck, S. B. (2007) · Sleep · doi:10.1093/sleep/30.2.219 · Cited by 344
Quality of sleep and health-related quality of life in haemodialysis patients
Iliescu, E. A. (2002) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/18.1.126 · Cited by 335
Elder, S. J., Pisoni, R. L., Akizawa, T., Fissell, R. B., Andreucci, V. E., Fukuhara, S., Kurokawa, K., Rayner, H. C., Furniss, A. L., Port, F. K., et al. (2007) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfm630 · Cited by 321
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Association of sleep habits with Alpha-MSH levels in patients with chronic kidney disease
Kandemir, T., & Gök, M. (2025) · BMC Nephrology · doi:10.1186/s12882-025-04604-3
Yu, S., Zhou, X., Xu, L., Fang, L., & Wang, Y. (2026) · PLoS ONE · doi:10.1371/journal.pone.0343236
Balogun, S. A., & Abdel‐Rahman, E. M. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-34069-7.00012-4
Vidyavati, H. G., Reddy, M., Patil, R., & Sridhar, L. (2026) · Nutrire · doi:10.1186/s41110-026-00529-5
Metadata
- Authors
- Chiu, Y.-L., Chuang, Y.-F., Fang, K.-C., Liu, S.-K., Chen, H.-Y., Yang, J.-Y., Pai, M.-F., Peng, Y.-S., Wu, K.-D., & Tsai, T.-J.
- Affiliations
- Far Eastern Memorial Hospital (TW)
- Min Sheng General Hospital (TW)
- National Taiwan University (TW)
- National Taiwan University Hospital (TW)
- Corresponding author
- Chiu, Y.-L.
- Venue
- Nephrology Dialysis Transplantation
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-08-06
- Volume
- 24
- Issue
- 1
- Pages
- 247-251
- ISSN
- 0931-0509 (ISSN-L)
- 1460-2385
- OpenAlex
- W2127162958
- Cited by
- 104
- References
- 34
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 5 · 2023: 7 · 2022: 4 · 2021: 1 · 2020: 9 · 2019: 8 · 2018: 5 · 2017: 3 · 2016: 2 · 2015: 11 · 2014: 8 · 2013: 5 · 2012: 6
- FWCI
- 5.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nephrology Dialysis Transplantation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
- Keywords
- sleep quality, systemic inflammation, hemodialysis, end-stage renal disease, C-reactive protein, triglycerides, IL-1β, serum phosphorus, sleep disorders, Pittsburgh Sleep Quality Index
- MeSH terms
- Adult, Aged, C-Reactive Protein, Female, Renal Dialysis, Hemoglobins, Humans, Inflammation, Sleep Initiation and Maintenance Disorders, Kidney Failure, Chronic, Male, Middle Aged, Phosphates, Sleep, Sleep Wake Disorders, Triglycerides, Interleukin-1beta
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