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Cited by 1,195Sleep and Work-Related FatigueSleep and Wakefulness ResearchSleep and related disorders

Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk

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Meier-Ewert, Hans K, Ridker, Paul M, Rifai, Nader, Regan, Meredith M, Price, Nick J, Dinges, David F, Mullington, Janet M·2004·Journal of the American College of Cardiology
DOI 10.1016/j.jacc.2003.07.050
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Abstract

Objectives We sought to investigate the effects of sleep loss on high-sensitivity C-reactive protein (CRP) levels.Background Concentrations of high-sensitivity CRP are predictive of future cardiovascular morbidity. In epidemiologic studies, short sleep duration and sleep complaints have also been associated with increased cardiovascular morbidity. Two studies were undertaken to examine the effect of acute total and short-term partial sleep deprivation on concentrations of high-sensitivity CRP in healthy human subjects.Methods In Experiment 1, 10 healthy adult subjects stayed awake for 88 continuous hours. Samples of high-sensitivity CRP were collected every 90 min for 5 consecutive days, encompassing the vigil. In Experiment 2, 10 subjects were randomly assigned to either 8.2 h (control) or 4.2 h (partial sleep deprivation) of nighttime sleep for 10 consecutive days. Hourly samples of high-sensitivity CRP were taken during a baseline night and on day 10 of the study protocol.Results The CRP concentrations increased during both total and partial sleep deprivation conditions, but remained stable in the control condition. Systolic blood pressure increased across deprivation in Experiment 1, and heart rate increased in Experiment 2.Conclusions Both acute total and short-term partial sleep deprivation resulted in elevated high-sensitivity CRP concentrations, a stable marker of inflammation that has been shown to be predictive of cardiovascular morbidity. We propose that sleep loss may be one of the ways that inflammatory processes are activated and contribute to the association of sleep complaints, short sleep duration, and cardiovascular morbidity observed in epidemiologic surveys.

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  • Sleep restriction without circadian disruption resulted in a marked elevation of serum hsCRP levels in men.

    “Consistent with previous studies of partial sleep deprivation in healthy young men (37,38), sleep restriction without circadian disruption resulted in a marked elevation of serum hsCRP levels in men.”

    From Circadian Misalignment Augments Markers of Insulin Resistance and Inflammation, Independently of Sleep Loss (2014) · cites this paper as [38]

    The Experiment 2 results report a marked, significant rise in high-sensitivity CRP after ten nights of restricted sleep, while the control group showed no significant change. But Experiment 2 included both men and women, and the paper does not establish that the rise occurred specifically in men or explicitly assess the absence of circadian disruption. (LLM, conf=0.87)

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  • Severe sleep loss has been shown to increase circulating levels of CRP.

    “Severe sleep loss has been shown to increase circulating levels of CRP (Meier-Ewert et al, 2004)”

    From Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond (2017) · cites this paper as Meier-Ewert et al, 2004

  • With increasing sleep loss across four nights, C-reactive protein accumulates.

    “as the 'dose' of sleep loss progressively increases over 4 nights, there is evidence of cumulative increase of C-reactive protein (CRP) (Meier-Ewert et al, 2004).”

    From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Meier-Ewert et al, 2004

  • After ten nights of losing 4 h of sleep per night, CRP and IL-6 rose.

    “10 nights of partial sleep deprivation (eg, loss of 4 h of sleep per night) led to increased levels of CRP and IL-6 (Meier-Ewert et al, 2004;Haack et al, 2007).”

    From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Meier-Ewert et al, 2004

  • Sleep loss is associated with increased levels of proinflammatory cytokines and low-grade inflammation, a condition that may predispose to insulin and leptin resistance.

    “Furthermore, sleep loss is associated with increased levels of proinflammatory cytokines and low-grade inflammation (reviewed in chapter 9 “Sleep loss and inflammation”), a condition that may predispose to insulin [69-71] and leptin resistance [72].”

    From Role of sleep duration in the regulation of glucose metabolism and appetite (2010) · cites this paper as [71]

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Research works printed but not linked: 1

  1. Shearer WT, Reuben JM, Mullington J, et al. Soluble tumor necrosis factor-alpha receptor I and IL-6 concentrations in humans subjected to the sleep deprivation model of space flight. J Allergy Clin Immunol 2001;107:165-70.

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Authors
Meier-Ewert, H. K., Ridker, P. M., Rifai, N., Regan, M. M., Price, N. J., Dinges, D. F., & Mullington, J. M.
Affiliations
  • Lahey Hospital and Medical Center (US)
  • Brigham and Women's Hospital (US)
  • Harvard University (US)
  • Beth Israel Deaconess Medical Center (US)
  • University of Pennsylvania (US)
Corresponding author
Mullington, Janet M
ORCID
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
2004-02
Volume
43
Issue
4
Pages
678-683
ISSN
0735-1097 (ISSN-L)
DOI
10.1016/j.jacc.2003.07.050
OpenAlex
W2101843129
Cited by
1,195
References
43
Citations by year
2026: 31 · 2025: 50 · 2024: 59 · 2023: 59 · 2022: 71 · 2021: 65 · 2020: 59 · 2019: 59 · 2018: 50 · 2017: 57 · 2016: 59 · 2015: 83 · 2014: 70 · 2013: 80 · 2012: 61
FWCI
44.59
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of the American College of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Aeronautics and Space Administration
  • National Space Biomedical Research Institute
  • National Institute on Aging (K23AG8672)
  • National Institute of Mental Health (R01MH060641, MH 60641)
  • National Institute of Nursing Research (NR04281, R01NR004281)
  • National Center for Research Resources (M01-RR-00040, M01RR000040)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
sleep deprivation, C-reactive protein, inflammation, cardiovascular risk, short sleep duration, systolic blood pressure, heart rate, cardiovascular morbidity
MeSH terms
Adult, Blood Pressure, C-Reactive Protein, Cardiovascular Diseases, Female, Heart Rate, Humans, Inflammation, Male, Monitoring, Physiologic, Risk, Sleep Deprivation, Time Factors, Biomarkers

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