Cigarette smoking and chronic kidney disease in the general population: a systematic review and meta-analysis of prospective cohort studies
Abstract
Background Cigarette smoking has been established as a major risk factor for chronic kidney disease (CKD) development in people with diabetes. Conflicting evidence exists among representative community-based studies as to whether smoking is an independent risk factor for CKD. The aim of this meta-analysis was to assess the effects of tobacco smoking on the development of CKD in adult general populations. Methods A literature search was conducted using MEDLINE and Embase from their inception through 31 May 2016 for prospective cohort studies that reported relative risks of CKD with smoking status in the general population. Summary relative risks (SRRs) and 95% confidence intervals (CIs) were calculated using a random effects model. Results A total of 15 prospective cohort studies, including 65 064 incident CKD cases, were included. Compared with never-smokers, the SRRs of incident CKD were 1.27 (95% CI 1.19-1.35) for ever-smokers, 1.34 (95% CI 1.23-1.47) for current smokers and 1.15 (95% CI 1.08-1.23) for former smokers. The SRRs for end-stage renal disease development were 1.51 (95% CI 1.24-1.84) for ever-smokers, 1.44 (95% CI 1.00-2.09) for former smokers and 1.91 (95% CI 1.39-2.64) for current smokers. Considerable heterogeneity was observed among these studies. After combining an additional three prospective cohort studies, which involved 5747 incident proteinuria cases, a null smoking-proteinuria association in the general population was observed. Conclusions Our meta-ana…
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Tobacco use remains a leading cause of death across the globe and is a known risk factor for the development of CKD.
“Tobacco use remains a leading cause of death across the globe and is also a known risk factor for the development of CKD.”
From KDIGO 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease (2022) · cites this paper as [179]
Cites
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Predictors of New-Onset Kidney Disease in a Community-Based Population
Fox, C. S. (2004) · JAMA · doi:10.1001/jama.291.7.844 · Cited by 1,241 · cited 14× · see citing works
“Fox et al./2004/ USA [7] • FHS: n ¼ 2585, M þ F • Age 42 years 18.5 • n ¼ 244, GFR < 59.25 ml/min/ 1.73 m2 in women, <64.25 ml/ min/1.73 m2 in men, MDRD equation Ever Age, sex, BMI, baseline GFR, DM Jee et al./2005/ Korea[8] • KMIC: n ¼ 157 377, M þ F • Age 44 (35–59) years 10 • Proteinuria: urine dipstick test • 3951…”
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KDIGO 2020 Clinical practice guideline for diabetes management in chronic kidney disease
de Boer, I. H., Caramori, M. L., Chan, J. C. N., Heerspink, H. J. L., Hurst, C., Khunti, K., Liew, A., Michos, E. D., Navaneethan, S. D., Olowu, W. A., et al. (2020) · Kidney International · doi:10.1016/j.kint.2020.06.019 · Cited by 1,399 · see citing works
KDIGO 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease
Rossing, P., Caramori, M. L., Chan, J. C. N., Heerspink, H. J. L., Hurst, C., Khunti, K., Liew, A., Michos, E. D., Navaneethan, S. D., Olowu, W. A., et al. (2022) · Kidney International · doi:10.1016/j.kint.2022.06.008 · Cited by 1,373 · see citing works
Crump, C., Sundquist, J., Winkleby, M. A., & Sundquist, K. (2019) · BMJ · doi:10.1136/bmj.l1346 · Cited by 265 · see citing works
Jhee, J. H., Joo, Y. S., Kee, Y. K., Jung, S.-Y., Park, S., Yoon, C.-Y., Han, S. H., Yoo, T.-H., Kang, S.-W., & Park, J. T. (2019) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.09540818 · Cited by 60 · see citing works
- Authors
- Xia, J., Wang, L., Ma, Z., Zhong, L., Wang, Y., Gao, Y., He, L., & Su, X.
- Affiliations
- Shanghai University of Traditional Chinese Medicine (CN)
- Shanghai Jiao Tong University (CN)
- Venue
- Nephrology Dialysis Transplantation
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-02-27
- Volume
- 32
- Issue
- 3
- Pages
- 475-487
- ISSN
- 0931-0509 (ISSN-L)
- 1460-2385
- OpenAlex
- W2600216720
- Cited by
- 285
- References
- 3
- Citations by year
- 2026: 33 · 2025: 35 · 2024: 50 · 2023: 38 · 2022: 37 · 2021: 22 · 2020: 36 · 2019: 18 · 2018: 12 · 2017: 3 · 2016: 1
- FWCI
- 2.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nephrology Dialysis Transplantation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Keywords
- cigarette smoking, chronic kidney disease, end-stage renal disease, smoking as risk factor, proteinuria, smoking cessation, general population, current smokers, former smokers
- MeSH terms
- Humans, Kidney Failure, Chronic, Prospective Studies, Risk Factors, Smoking, Cohort Studies, Renal Insufficiency, Chronic
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