The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The effects of the recommended dose of creatine monohydrate on kidney function
Open accessAbstract
We report a case of a heretofore healthy 18-year-old man who presented with a 2-day history of nausea, vomiting and stomach ache while taking creatine monohydrate for bodybuilding purposes. The patient had acute renal failure, and a renal biopsy was performed to determine the cause of increased creatinine and proteinuria. The biopsy showed acute tubular necrosis. In the literature, creatine monohydrate supplementation and acute tubular necrosis coexistence had not been reported previously. Twenty-five days after stopping the creatine supplements, the patient recovered fully. Even recommended doses of creatine monohydrate supplementation may cause kidney damage; therefore, anybody using this supplement should be warned about this possible side effect, and their renal functions should be monitored regularly.
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“Early reports are the main source of these concerns [5–10], animal studies [11], and the clinical reliance on serum creatinine.”
From Effect of creatine supplementation on kidney function: a systematic review and meta-analysis (2025) · cites this paper as [9]
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Cites
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Mayhew, D. L., Mayhew, J. L., & Ware, J. S. (2002) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.12.4.453 · Cited by 66
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Chilibeck, P., Kaviani, M., Candow, D., & Zello, G. A. (2017) · Open Access Journal of Sports Medicine · doi:10.2147/oajsm.s123529 · Cited by 235
de Guingand, D. L., Palmer, K. R., Snow, R. J., Davies-Tuck, M. L., & Ellery, S. J. (2020) · Nutrients · doi:10.3390/nu12061780 · Cited by 35
Is It Time for a Requiem for Creatine Supplementation-Induced Kidney Failure? A Narrative Review
Longobardi, I., Gualano, B., Seguro, A. C., & Roschel, H. (2023) · Nutrients · doi:10.3390/nu15061466 · Cited by 31
Effect of creatine supplementation on kidney function: a systematic review and meta-analysis
Naeini, E. K., Eskandari, M., Mortazavi, M., Gholaminejad, A., & Karevan, N. (2025) · BMC Nephrology · doi:10.1186/s12882-025-04558-6 · Cited by 36
Metadata
- Authors
- Taner, B., Aysim, O., & Abdulkadir, U.
- Affiliations
- Bağcılar Eğitim ve Araştırma Hastanesi (TR)
- Şişli Etfal Eğitim ve Araştırma Hastanesi (TR)
- Corresponding author
- Taner, B.
- ORCID
- Abdulkadir, U.
- Venue
- Clinical Kidney Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-10-11
- Volume
- 4
- Issue
- 1
- Pages
- 23-24
- ISSN
- 2048-8505 (ISSN-L)
- 2048-8513
- PMC
- PMC4421632
- OpenAlex
- W2101103861
- Cited by
- 39
- References
- 3
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 2 · 2020: 3 · 2019: 4 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 1 · 2012: 1
- FWCI
- 0.25
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Clinical Kidney Journal (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Health Sciences › Medicine › Nephrology › Nephrotoxicity and Medicinal Plants
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- creatine monohydrate, acute tubular necrosis, acute kidney injury, creatine supplementation, bodybuilding supplements, proteinuria, renal biopsy, renal function monitoring
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