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Cited by 213Muscle metabolism and nutritionAcute Kidney Injury ResearchDialysis and Renal Disease Management

Renal dysfunction accompanying oral creatine supplements

Pritchard, NR, Kalra, PA·1998·The Lancet
DOI 10.1016/s0140-6736(05)79319-3
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  • A few case studies reported that individuals purportedly taking creatine with or without other supplements presented with high creatinine levels and/or renal dysfunction.

    “With regard to the question of whether creatine has effect on renal function, a few case studies [249–252] reported that individuals purportedly taking creatine with or without other supplements presented with high creatinine levels and/or renal dysfunction [249–251].”

    From International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine (2017) · cites this paper as [251]

  • In that 1998 case study, based on increased blood levels of creatinine and subsequent estimate of calculated creatinine clearance, the patient's kidney health was presumed to be deteriorating, although he was otherwise in good health.

    “Based on increased blood levels of creatinine and subsequent estimate of calculated creatinine clearance, his kidney health was presumed to be deteriorating, although he was otherwise in good health.”

    From Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show? (2021) · cites this paper as [51]

  • In 1998, a case study reported a young male with focal segmental glomerulosclerosis and relapsing nephrotic syndrome who had recently begun ingesting creatine supplementation at 15 g/day for 7 days followed by 2 g/day for 7 weeks.

    “In 1998, a case study of a young male with focal segmental glomerulosclerosis and relapsing nephrotic syndrome was reported [51]. The young male, who had kidney disease for 8 years and was treated with cyclosporine (i.e., immunosuppressant) for 5 years, had recently begun ingesting creatine supplementation (15 g/day for 7 days; followed by 2 g/day for 7 weeks).”

    From Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show? (2021) · cites this paper as [51]

  • A few case study reports appeared in the literature suggesting adverse events despite other mitigating factors unrelated to creatine supplementation, which subsequently have been debunked.

    “A few case study reports also appeared in the literature suggesting adverse events despite other mitigating factors unrelated to creatine supplementation [52–54] which subsequently have been debunked [15,55,56].”

    From Safety of creatine supplementation: analysis of the prevalence of reported side effects in clinical trials and adverse event reports (2025) · cites this paper as [52]

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Authors
Pritchard, N., & Kalra, P.
Affiliations
Salford Royal NHS Foundation Trust (GB)
Venue
The Lancet
Publisher
Elsevier BV
Published
1998-04
Volume
351
Issue
9111
Pages
1252-1253
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
DOI
10.1016/s0140-6736(05)79319-3
OpenAlex
W1973648573
Cited by
213
References
4
Citations by year
2026: 4 · 2025: 5 · 2024: 4 · 2023: 5 · 2022: 3 · 2021: 5 · 2020: 5 · 2019: 7 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 8 · 2014: 6 · 2013: 1 · 2012: 8
FWCI
5.39
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Lancet (publishedVersion)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
  • Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
Keywords
creatine supplementation, renal dysfunction, creatine loading, serum creatinine, exercise performance, dietary supplements, drug safety
MeSH terms
Administration, Oral, Adult, Creatine, Glomerular Filtration Rate, Humans, Male, Nephrotic Syndrome, Dietary Supplements

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