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Cited by 280

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Seizures in low-grade gliomas: natural history, pathogenesis, and outcome after treatments

Open access
Ruda, R., Bello, L., Duffau, H., Soffietti, R.·2012·Neuro-Oncology

Abstract

Seizures represent a common symptom in low-grade gliomas; when uncontrolled, they significantly contribute to patient morbidity and negatively impact quality of life. Tumor location and histology influence the risk for epilepsy. The pathogenesis of tumor-related epilepsy is multifactorial and may differ among tumor histologies (glioneuronal tumors vs diffuse grade II gliomas). Gross total resection is the strongest predictor of seizure freedom in addition to clinical factors, such as preoperative seizure duration, type, and control with antiepileptic drugs (AEDs). Epilepsy surgery may improve seizure control. Radiotherapy and chemotherapy with alkylating agents (procarbazine + CCNU+ vincristine, temozolomide) are effective in reducing the frequency of seizures in patients with pharmacoresistant epilepsy. Newer AEDs (levetiracetam, topiramate, lacosamide) seem to be better tolerated than the old AEDs (phenobarbital, phenytoin, carbamazepine), but there is lack of evidence regarding their superiority in terms of efficacy.

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Crossref · 10.1093/neuonc/nos199

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Metadata

Authors
Ruda, R., Bello, L., Duffau, H., & Soffietti, R.
Venue
Neuro-Oncology
Published
2012-09-01
Volume
14
Issue
suppl 4
Pages
iv55-iv64
ISSN
  • 1522-8517 (ISSN-L)
  • 1523-5866
OpenAlex
W2105420171
Cited by
280
References
4
FWCI
10.04
Type
journal article
Language
en
Open access
green

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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