How do brain tumors alter functional connectivity? A magnetoencephalography study
Abstract
Objective: This study was undertaken to test the hypothesis that brain tumors interfere with normal brain function by disrupting functional connectivity of brain networks. Methods: Functional connectivity was assessed by computing the synchronization likelihood in a broad band (0.5–60Hz) or in the gamma band (30–60Hz) between all pairwise combinations of magnetoencephalography signals. Magnetoencephalography recordings were made at rest in 17 brain tumor patients and 15 healthy control subjects. For a given threshold of synchronization likelihood values, graphs of the suprathreshold connections between each magnetoencephalography channel and the others channels were built. Results: In some regions, a variable number of channels without connectivity (missing connective points) at this threshold was found. The number of missing connective points was higher in patients with brain tumors than in control subjects (p < 0.0001, broad and gamma band) and was higher for left‐sided than right‐sided tumors (p = 0.008, broad band; p < 0.0001, gamma band). Individual results analysis indicates that the majority of brain tumor patients display several regions with missing connective point alterations in the affected and in the contralateral hemisphere. Interpretation: Our findings suggest that brain tumors induce a loss of functional connectivity that affects multiple brain regions, and that left side brain tumors have the more severe consequences in this respect. Ann Neurol 2005
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Patients with tumors in the frontal and temporal but not parietal lobes have reduced efficiency.
“Specific findings include reduced efficiency in patients with tumors in the frontal and temporal but not parietal lobes.”
From Graph theory analysis of complex brain networks: new concepts in brain mapping applied to neurosurgery (2016) · cites this paper as [9]
In patients with brain tumors, brain networks are more random and less organized, not just locally but diffusely.
“In general, brain networks in patients with tumors have been found to be more random and less organized, not just locally but in a diffuse manner.”
From Graph theory analysis of complex brain networks: new concepts in brain mapping applied to neurosurgery (2016) · cites this paper as [9]
Network hubs were reorganized in patients with brain tumors, with the right insula being a hub in controls but not in patients.
“network hubs were reorganized, with the right insula being a hub in controls but not in patients.”
From Graph theory analysis of complex brain networks: new concepts in brain mapping applied to neurosurgery (2016) · cites this paper as [9]
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- Authors
- Bartolomei, F., Bosma, I., Klein, M., Baayen, J. C., Reijneveld, J. C., Postma, T. J., Heimans, J. J., van Dijk, B. W., de Munck, J. C., de Jongh, A., Cover, K. S., & Stam, C. J.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- ORCID
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2005-12-22
- Volume
- 59
- Issue
- 1
- Pages
- 128-138
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2040080135
- Cited by
- 180
- References
- 39
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 8 · 2023: 9 · 2022: 6 · 2021: 9 · 2020: 8 · 2019: 7 · 2018: 9 · 2017: 13 · 2016: 9 · 2015: 10 · 2014: 10 · 2013: 12 · 2012: 14
- FWCI
- 2.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- brain tumors, functional connectivity, synchronization likelihood, gamma band, magnetoencephalography, brain network disruption, hemispheric lateralization, contralateral hemisphere
- MeSH terms
- Adult, Aged, Brain Neoplasms, Female, Humans, Male, Middle Aged, Nerve Net, Seizures, Magnetoencephalography
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