Cited by 145Functional Brain Connectivity StudiesGlioma Diagnosis and TreatmentNeural dynamics and brain function

Synchronized brain activity and neurocognitive function in patients with low-grade glioma: A magnetoencephalography study

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Bosma, Ingeborg, Douw, Linda, Bartolomei, Fabrice, Heimans, Jan J., van Dijk, Bob W., Postma, Tjeerd J., Stam, Cornelis J., Reijneveld, Jaap C. +1 more·2008·Neuro-Oncology

Abstract

We investigated the mechanisms underlying neurocognitive dysfunction in patients with low-grade glioma (LGG) by relating functional connectivity revealed by magnetoencephalography to neurocognitive function. We administered a battery of standardized neurocognitive tests measuring six neurocognitive domains to a group of 17 LGG patients and 17 healthy controls, matched for age, sex, and educational level. Magnetoencephalography recordings were conducted during an eyes-closed "resting state," and synchronization likelihood (a measure of statistical correlation between signals) was computed from the delta to gamma frequency bands to assess functional connectivity between different brain areas. We found that, compared with healthy controls, LGG patients performed more poorly in psychomotor function, attention, information processing, and working memory. LGG patients also had significantly higher long-distance synchronization scores in the delta, theta, and lower gamma frequency bands than did controls. In contrast, patients displayed a decline in synchronization likelihood in the lower alpha frequency band. Within the delta, theta, and lower and upper gamma bands, increasing short- and long-distance connectivity was associated with poorer neurocognitive functioning. In summary, LGG patients showed a complex overall pattern of differences in functional resting-state connectivity compared with healthy controls. The significant correlations between neurocognitive performance and functional connectivity in various frequencies and across multiple brain areas suggest that the observed neurocognitive deficits in these patients can possibly be attributed to differences in functional connectivity due to tumor and/or treatment.

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Crossref · 10.1215/15228517-2008-034

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  • The degree to which network features are perturbed correlates with neuropsychological deficits, with reduced global efficiency and small-worldness correlated with lower IQ scores.

    “The degree to which network features are perturbed has been correlated with neuropsychological deficits involving both local and diffuse brain regions with reduced global efficiency and small-worldness correlated with lower IQ scores.15,16,104”

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Authors
Bosma, I., Douw, L., Bartolomei, F., Heimans, J. J., van Dijk, B. W., Postma, T. J., Stam, C. J., Reijneveld, J. C., & Klein, M.
Affiliations
Amsterdam UMC Location University of Amsterdam (NL)
Corresponding author
Bosma, Ingeborg
Venue
Neuro-Oncology
Published
2008-10-01
Volume
10
Issue
5
Pages
734-744
ISSN
  • 1522-8517 (ISSN-L)
  • 1523-5866
OpenAlex
W2136372537
Cited by
145
References
56
Citations by year
2026: 2 · 2025: 6 · 2024: 5 · 2023: 7 · 2022: 10 · 2021: 8 · 2020: 10 · 2019: 8 · 2018: 6 · 2017: 15 · 2016: 7 · 2015: 7 · 2014: 6 · 2013: 15 · 2012: 8
FWCI
4.32
Type
journal article
Language
en
Open access
Locations
  • Neuro-Oncology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
  • VU Research Portal (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
low-grade glioma, neurocognitive impairment, functional connectivity, synchronization likelihood, delta oscillations, theta oscillations, gamma oscillations, alpha oscillations, working memory, attention, psychomotor performance, information processing, brain tumors
MeSH terms
Adult, Brain Neoplasms, Cognition Disorders, Cortical Synchronization, Female, Glioma, Humans, Male, Magnetoencephalography

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