The DOI matches its Crossref record; 95 of the 95 references it cites were found in a registry or an index.
Hypoxia in the glioblastoma microenvironment: shaping the phenotype of cancer stem-like cells
Open accessAbstract
Glioblastoma is the most common and aggressive malignant primary brain tumor. Cellular heterogeneity is a characteristic feature of the disease and contributes to the difficulty in formulating effective therapies. Glioma stem-like cells (GSCs) have been identified as a subpopulation of tumor cells that are thought to be largely responsible for resistance to treatment. Intratumoral hypoxia contributes to maintenance of the GSCs by supporting the critical stem cell traits of multipotency, self-renewal, and tumorigenicity. This review highlights the interaction of GSCs with the hypoxic tumor microenvironment, exploring the mechanisms underlying the contribution of GSCs to tumor vessel dynamics, immune modulation, and metabolic alteration.
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Cited by
Emami Nejad, A., Najafgholian, S., Rostami, A., Sistani, A., Shojaeifar, S., Esparvarinha, M., Nedaeinia, R., Haghjooy Javanmard, S., Taherian, M., Ahmadlou, M., et al. (2021) · Cancer Cell International · doi:10.1186/s12935-020-01719-5 · Cited by 693
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Cancer stem cell (CSC) resistance drivers
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Serine-dependent redox homeostasis regulates glioblastoma cell survival
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Metadata
- Authors
- Colwell, N., Larion, M., Giles, A. J., Seldomridge, A. N., Sizdahkhani, S., Gilbert, M. R., & Park, D. M.
- Venue
- Neuro-Oncology
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-01-19
- Volume
- 19
- Issue
- 7
- Pages
- 887-896
- ISSN
- 1522-8517 (ISSN-L)
- 1523-5866
- OpenAlex
- W2624969848
- Cited by
- 284
- References
- 95
- FWCI
- 4.95
- Type
- journal article
- Language
- en
- Open access
- green
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- Colwell, N., Larion, M., Giles, A. J., Seldomridge, A. N., Sizdahkhani, S., Gilbert, M. R., & Park, D. M. (2017). Hypoxia in the glioblastoma microenvironment: shaping the phenotype of cancer stem-like cells. Neuro-Oncology. https://doi.org/10.1093/neuonc/now258
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