The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Plasma metabolomic and lipidomic alterations associated with COVID-19
Open accessAbstract
The pandemic of the coronavirus disease 2019 (COVID-19) has become a global public health crisis. The symptoms of COVID-19 range from mild to severe, but the physiological changes associated with COVID-19 are barely understood. In this study, we performed targeted metabolomic and lipidomic analyses of plasma from a cohort of patients with COVID-19 who had experienced different symptoms. We found that metabolite and lipid alterations exhibit apparent correlation with the course of disease in these patients, indicating that the development of COVID-19 affected their whole-body metabolism. In particular, malic acid of the TCA cycle and carbamoyl phosphate of the urea cycle result in altered energy metabolism and hepatic dysfunction, respectively. It should be noted that carbamoyl phosphate is profoundly down-regulated in patients who died compared with patients with mild symptoms. And, more importantly, guanosine monophosphate (GMP), which is mediated not only by GMP synthase but also by CD39 and CD73, is significantly changed between healthy subjects and patients with COVID-19, as well as between the mild and fatal cases. In addition, dyslipidemia was observed in patients with COVID-19. Overall, the disturbed metabolic patterns have been found to align with the progress and severity of COVID-19. This work provides valuable knowledge about plasma biomarkers associated with COVID-19 and potential therapeutic targets, as well as an important resource for further studies of the pathogenesis of COVID-19.
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1 retracted
Effect of Malate-oligosaccharide Solution on Antioxidant Capacity of Endurance Athletes
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La certeza de lo impredecible: Cultura Educación y Sociedad en tiempos de COVID19
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Cited by
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Self-citationCellular senescence as a potential mediator of COVID‐19 severity in the elderly
Nehme, J., Borghesan, M., Mackedenski, S., Bird, T. G., & Demaria, M. (2020) · Aging Cell · doi:10.1111/acel.13237 · Cited by 94
Metadata
- Authors
- Wu, D., Shu, T., Yang, X., Song, J.-X., Zhang, M., Yao, C., Liu, W., Huang, M., Yu, Y., Yang, Q., Zhu, T., Xu, J., Mu, J., Wang, Y., Wang, H., Tang, T., Ren, Y., Wu, Y., Lin, S.-H., Qiu, Y., Zhang, D.-Y., Shang, Y., & Zhou, X.
- Venue
- National Science Review
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-04-28
- Volume
- 7
- Issue
- 7
- Pages
- 1157-1168
- ISSN
- 2053-714X (ISSN-L)
- 2095-5138
- OpenAlex
- W3020649533
- Cited by
- 361
- References
- 34
- FWCI
- 19.02
- Type
- journal article
- Language
- en
- Open access
- gold
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- Wu, D., Shu, T., Yang, X., Song, J.-X., Zhang, M., Yao, C., Liu, W., Huang, M., Yu, Y., Yang, Q., Zhu, T., Xu, J., Mu, J., Wang, Y., Wang, H., Tang, T., Ren, Y., Wu, Y., Lin, S.-H., . . . Zhou, X. (2020). Plasma metabolomic and lipidomic alterations associated with COVID-19. National Science Review. https://doi.org/10.1093/nsr/nwaa086
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