Determination of Nicotine Absorption from Multiple Tobacco Products and Nicotine Gum
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The mean nicotine Cmax measured during use of the 8 mg NP (15.4 ng/mL) was within the range reported in published literature for cigarettes (11.8 to 23 ng/mL) and MST products (10.6 to 21.4 ng/ml).
“the mean nicotine Cmax measured during use of the 8 mg NP (15.4 ng/mL) was within the range reported in published literature”
From Nicotine pharmacokinetics and subjective responses after using nicotine pouches with different nicotine levels compared to combustible cigarettes and moist smokeless tobacco in adult tobacco users (2022) · cites this paper as Digard et al. 2013
Table 3 (Results, Nicotine Pharmacokinetics; page unavailable) reports snus Cmax values of 10.8–17.9 ng/mL, a range that includes the citing study’s 15.4 ng/mL value. It reports only one cigarette Cmax, 12.8 ng/mL, and does not give the quoted cigarette or MST ranges of 11.8–23 and 10.6–21.4 ng/mL. The source therefore supports the snus comparison, but not the specific literature ranges attributed to it. (LLM, conf=0.86)
Experimental — accuracy not yet measuredA 60-min usage time was selected based on prior snus pouch nicotine pharmacokinetic studies that had a 60-min mouth hold time based on product use data.
“In this study, a 60-min usage time was selected based on prior snus pouch nicotine pharmacokinetic studies that had a 60-min mouth hold time based on product use data [24, 25].”
From A Randomised Study to Investigate the Nicotine Pharmacokinetics of Oral Nicotine Pouches and a Combustible Cigarette (2022) · cites this paper as [25]
Previous studies have reported greater AUC and Cmax values for some types of snus than for cigarettes, probably due to the longer period of snus use relative to smoking a single cigarette.
“previous studies have similarly reported greater AUC and Cmax values for some types of snus than for cigarettes [25–27], probably due to the longer period of snus use relative to smoking a single cigarette.”
From A Randomised Study to Investigate the Nicotine Pharmacokinetics of Oral Nicotine Pouches and a Combustible Cigarette (2022) · cites this paper as [25]
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Cites
CYP2A6 genotype and the metabolism and disposition kinetics of nicotine
BENOWITZ, N., SWAN, G., JACOBIII, P., LESSOVSCHLAGGAR, C., & TYNDALE, R. (2006) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2006.08.011 · Cited by 217 · see citing works
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Research works printed but not linked: 13
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Cited by
Sorted by citations
McEwan, M., Azzopardi, D., Gale, N., Camacho, O. M., Hardie, G., Fearon, I. M., & Murphy, J. (2022) · European Journal of Drug Metabolism and Pharmacokinetics · doi:10.1007/s13318-021-00742-9 · Cited by 70 · see citing works
Liu, J., Rensch, J., Wang, J., Jin, X., Vansickel, A., Edmiston, J., & Sarkar, M. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06172-y · Cited by 37 · see citing works
- Authors
- Digard, H., Proctor, C., Kulasekaran, A., Malmqvist, U., & Richter, A.
- Venue
- Nicotine & Tobacco Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-05-13
- Volume
- 15
- Issue
- 1
- Pages
- 255-261
- ISSN
- 1462-2203
- 1469-994X
- PMC
- PMC3524070
- Cited by
- 104
- References
- 1
- Language
- en
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