Cited by 67Probiotics and Fermented FoodsGut microbiota and healthMicrobial Metabolites in Food Biotechnology

Preclinical and clinical relevance of probiotics and synbiotics in colorectal carcinogenesis: a systematic review

Cruz, Bruna C S, Sarandy, Mariáurea M, Messias, Anny C, Gonçalves, Reggiani V, Ferreira, Célia L L F, Peluzio, Maria C G·2020·Nutrition Reviews

Abstract

CONTEXT: Recent evidence suggests that modulation of the gut microbiota may help prevent colorectal cancer. OBJECTIVE: The aim of this systematic review was to investigate the role of probiotics and synbiotics in the prevention of colorectal cancer and to clarify potential mechanisms involved. DATA SOURCES: The PubMed, ScienceDirect, and LILACS databases were searched for studies conducted in humans or animal models and published up to August 15, 2018. STUDY SELECTION: Clinical trials and placebo-controlled experimental studies that evaluated the effects of probiotics and synbiotics in colorectal cancer and cancer associated with inflammatory bowel disease were included. Of 247 articles identified, 31 remained after exclusion criteria were applied. A search of reference lists identified 5 additional studies, for a total of 36 included studies. DATA EXTRACTION: Two authors independently assessed risk of bias of included studies and extracted data. Data were pooled by type of study, ie, preclinical or clinical. RESULTS: The results showed positive effects of probiotics and synbiotics in preventing colorectal cancer. The main mechanisms identified were alterations in the composition and metabolic activity of the intestinal microbiota; reduction of inflammation; induction of apoptosis and inhibition of tumor growth; modulation of immune responses and cell proliferation; enhanced function of the intestinal barrier; production of compounds with anticarcinogenic activity; and modulation of oxidative stress. CONCLUSIONS: Probiotics or synbiotics may help prevent colorectal cancer, but additional studies in humans are required to better inform clinical practice.

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Crossref · 10.1093/nutrit/nuz087

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Authors
Cruz, B. C. S., Sarandy, M. M., Messias, A. C., Gonçalves, R. V., Ferreira, C. L. L. F., & Peluzio, M. C. G.
Affiliations
  • Department of Nutrition and Health, Nutritional Biochemistry Laboratory, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil
  • Universidade Federal de Viçosa (BR)
  • Institute of Biotechnology Applied to Agriculture (BIOAGRO), Laboratory of Dairy Cultures, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil
Venue
Nutrition Reviews
Published
2020-01-09
Volume
78
Issue
8
Pages
667-687
ISSN
  • 0029-6643 (ISSN-L)
  • 1753-4887
OpenAlex
W2999899495
Cited by
67
References
87
Citations by year
2026: 5 · 2025: 8 · 2024: 13 · 2023: 8 · 2022: 13 · 2021: 12 · 2020: 8
FWCI
0.74
Type
journal article
Language
en
Open access
closed
Locations
  • Nutrition Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Council for Scientific and Technological Development
  • CNPq
  • Coordination for the Improvement of Higher Education Personnel
  • CAPES
  • Minas Gerais State Research Support Foundation
  • FAPEMIG
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords
probiotics, synbiotics, colorectal cancer prevention, colorectal carcinogenesis, gut microbiota, inflammatory bowel disease, intestinal inflammation, apoptosis, tumor growth inhibition, intestinal barrier, oxidative stress, anticarcinogenic compounds, immunomodulation
MeSH terms
Gastrointestinal Microbiome, Adult, Aged, Aged, 80 and over, Animals, Female, Humans, Inflammation, Intestines, Male, Middle Aged, Colorectal Neoplasms, Inflammatory Bowel Diseases, Probiotics, Mice, Rats, Synbiotics, Carcinogenesis

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