Preclinical and clinical relevance of probiotics and synbiotics in colorectal carcinogenesis: a systematic review
Abstract
CONTEXT: Recent evidence suggests that modulation of the gut microbiota may help prevent colorectal cancer. OBJECTIVE: The aim of this systematic review was to investigate the role of probiotics and synbiotics in the prevention of colorectal cancer and to clarify potential mechanisms involved. DATA SOURCES: The PubMed, ScienceDirect, and LILACS databases were searched for studies conducted in humans or animal models and published up to August 15, 2018. STUDY SELECTION: Clinical trials and placebo-controlled experimental studies that evaluated the effects of probiotics and synbiotics in colorectal cancer and cancer associated with inflammatory bowel disease were included. Of 247 articles identified, 31 remained after exclusion criteria were applied. A search of reference lists identified 5 additional studies, for a total of 36 included studies. DATA EXTRACTION: Two authors independently assessed risk of bias of included studies and extracted data. Data were pooled by type of study, ie, preclinical or clinical. RESULTS: The results showed positive effects of probiotics and synbiotics in preventing colorectal cancer. The main mechanisms identified were alterations in the composition and metabolic activity of the intestinal microbiota; reduction of inflammation; induction of apoptosis and inhibition of tumor growth; modulation of immune responses and cell proliferation; enhanced function of the intestinal barrier; production of compounds with anticarcinogenic activity; and modulation of oxidative stress. CONCLUSIONS: Probiotics or synbiotics may help prevent colorectal cancer, but additional studies in humans are required to better inform clinical practice.
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Probiotic bacteria are being investigated for their alternative biotherapeutic potential against colon cancer.
“As recently investigated, probiotic bacteria are being investigated for their alternative biotherapeutic potential against colon cancer [5,6].”
From Bioprophylactic potential of novel human colostrum probiotics via apoptotic induction of colon cancer cells and cell immune activation (2022) · cites this paper as [6]
SCFA bioproduction by probiotics is one of the several mechanisms related to colon cancer protection and biotherapy.
“SCFA bioproduction by probiotics is one of the several mechanisms related to colon cancer protection and biotherapy [5,6].”
From Bioprophylactic potential of novel human colostrum probiotics via apoptotic induction of colon cancer cells and cell immune activation (2022) · cites this paper as [6]
Immune stimulation is one of the biotherapeutic actions of potential probiotics for protection and treatment against colon cancer.
“Immune stimulation is one of the biotherapeutic actions of potential probiotics for protection and treatment [5,6] against colon cancer.”
From Bioprophylactic potential of novel human colostrum probiotics via apoptotic induction of colon cancer cells and cell immune activation (2022) · cites this paper as [6]
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- Authors
- Cruz, B. C. S., Sarandy, M. M., Messias, A. C., Gonçalves, R. V., Ferreira, C. L. L. F., & Peluzio, M. C. G.
- Affiliations
- Department of Nutrition and Health, Nutritional Biochemistry Laboratory, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil
- Universidade Federal de Viçosa (BR)
- Institute of Biotechnology Applied to Agriculture (BIOAGRO), Laboratory of Dairy Cultures, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil
- Venue
- Nutrition Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-01-09
- Volume
- 78
- Issue
- 8
- Pages
- 667-687
- ISSN
- 0029-6643 (ISSN-L)
- 1753-4887
- OpenAlex
- W2999899495
- Cited by
- 67
- References
- 87
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 13 · 2023: 8 · 2022: 13 · 2021: 12 · 2020: 8
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Nutrition Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Council for Scientific and Technological Development
- CNPq
- Coordination for the Improvement of Higher Education Personnel
- CAPES
- Minas Gerais State Research Support Foundation
- FAPEMIG
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- probiotics, synbiotics, colorectal cancer prevention, colorectal carcinogenesis, gut microbiota, inflammatory bowel disease, intestinal inflammation, apoptosis, tumor growth inhibition, intestinal barrier, oxidative stress, anticarcinogenic compounds, immunomodulation
- MeSH terms
- Gastrointestinal Microbiome, Adult, Aged, Aged, 80 and over, Animals, Female, Humans, Inflammation, Intestines, Male, Middle Aged, Colorectal Neoplasms, Inflammatory Bowel Diseases, Probiotics, Mice, Rats, Synbiotics, Carcinogenesis
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