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Evolution of Infectious Disease
Abstract
Ewald is the first author to present a Darwinian perspective on infectious disease, which opens up a whole new approach to health science, one that emphasizes new possibilities for combatting deadly diseases like malaria, tuberculosis, and AIDS. Taking an evolutionary approach, Ewald views disease-producing bacteria and viruses as parasites and explains the history of disease as a host-parasite relationship, one which can evolve in many different effects on the host population. He explains why the agents of cholera, malaria, and AIDS are so dangerous and why treatment of virtually all diseases would be improved by applications of evolutionary principles. This merging of evolutionary biology with health sciences offers a new dimension to policy-making in the health sciences by identifying interventions that will force infectious organisms to evolve toward a benign state, to subdue the plagues of the past and help us to avert the plagues of the future. A wholly readable account of an enthralling and important subject of concern to us all.
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“Infectious diseases were a major source of morbidity and mortality, and hence of natural selection, in human evolutionary history”
From Parasite-stress promotes in-group assortative sociality: The cases of strong family ties and heightened religiosity (2012) · cites this paper as Ewald 1994
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Recognition of microorganisms and activation of the immune response
Medzhitov, R. (2007) · Nature · doi:10.1038/nature06246 · Cited by 2,862
Humans as the World's Greatest Evolutionary Force
Palumbi, S. R. (2001) · Science · doi:10.1126/science.293.5536.1786 · Cited by 1,290
Pathogen prevalence predicts human cross-cultural variability in individualism/collectivism
Fincher, C. L., Thornhill, R., Murray, D. R., & Schaller, M. (2008) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2008.0094 · Cited by 1,014
Fincher, C. L., & Thornhill, R. (2012) · Behavioral and Brain Sciences · doi:10.1017/s0140525x11000021 · Cited by 530
Parasites, democratization, and the liberalization of values across contemporary countries
Thornhill, R., Fincher, C. L., & Aran, D. (2009) · Biological Reviews · doi:10.1111/j.1469-185x.2008.00062.x · Cited by 260
Metadata
- Authors
- Ewald, P. W.
- Affiliations
- Amherst College (US)
- Corresponding author
- Ewald, Paul W
- ORCID
- Ewald, Paul W
- Publisher
- Oxford University PressNew York, NY
- Published
- 1994-01-06
- OpenAlex
- W4388331292
- Cited by
- 714
- References
- 0
- Citations by year
- 2026: 7 · 2025: 22 · 2024: 16 · 2023: 13 · 2022: 15 · 2021: 15 · 2020: 15 · 2019: 17 · 2018: 24 · 2017: 20 · 2016: 14 · 2015: 19 · 2014: 20 · 2013: 22 · 2012: 23
- FWCI
- 14.12
- Type
- book
- Language
- en
- Open access
- closed
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Social Sciences › Arts and Humanities › History and Philosophy of Science › Philosophy of Biology and Scientific Explanation
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Zoonotic diseases and public health
- Keywords
- evolutionary medicine, infectious diseases, host-parasite coevolution, malaria, tuberculosis, AIDS, cholera, health policy
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