Social Regulation of Gene Expression in the Immune System
Abstract
Social factors influence health in part by altering the expression of genes in diseased tissue and immune cells. This chapter surveys the emerging field of social genomics, which has begun to identify the types of genes subject to social regulation, the biological signaling pathways mediating those effects, and the genetic polymorphisms that moderate socioenvironmental influences on human gene expression. After highlighting the implications of these dynamics for immune response and host defense, this chapter considers the evolutionary basis for the deep functional connections between social behavior and immune response.
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NFκB and AP-1 translocate into the nucleus, bind cis-regulatory DNA sequences, and up-regulate the expression of proinflammatory immune response genes including IL1B, IL6, IL8, and TNF.
“These interactions cause NFκ B and AP-1 to translocate into the nucleus of the cell where they bind to cis -regulatory DNA sequences and up-regulate the expression of proinflammatory immune response genes including IL1B, IL6, IL8, and TNF”
From From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. (2014) · cites this paper as S. W. Cole, 2012
Cites
Perceived social isolation and cognition
Cacioppo, J. T., & Hawkley, L. C. (2009) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2009.06.005 · Cited by 2,144 · see citing works
Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma
Thaker, P. H., Han, L. Y., Kamat, A. A., Arevalo, J. M., Takahashi, R., Lu, C., Jennings, N. B., Armaiz-Pena, G., Bankson, J. A., Ravoori, M., et al. (2006) · Nature Medicine · doi:10.1038/nm1447 · Cited by 1,320 · see citing works
Self-citationThe influence of bio-behavioural factors on tumour biology: pathways and mechanisms
Antoni, M. H., Lutgendorf, S. K., Cole, S. W., Dhabhar, F. S., Sephton, S. E., McDonald, P. G., Stefanek, M., & Sood, A. K. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1820 · Cited by 981 · see citing works
Self-citationMiller, G. E., Chen, E., Fok, A. K., Walker, H., Lim, A., Nicholls, E. F., Cole, S., & Kobor, M. S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902971106 · Cited by 822 · see citing works
Self-citationSocial regulation of gene expression in human leukocytes
Cole, S. W., Hawkley, L. C., Arevalo, J. M., Sung, C. Y., Rose, R. M., & Cacioppo, J. T. (2007) · Genome Biology · doi:10.1186/gb-2007-8-9-r189 · Cited by 745 · see citing works
Self-citationLoneliness, social network size, and immune response to influenza vaccination in college freshmen
Pressman, S. D., Cohen, S., Miller, G. E., Barkin, A., Rabin, B. S., & Treanor, J. J. (2005) · Health Psychology · doi:10.1037/0278-6133.24.3.297 · Cited by 608 · see citing works
Miller, G., Chen, E., & Cole, S. W. (2009) · Annual Review of Psychology · doi:10.1146/annurev.psych.60.110707.163551 · Cited by 591 · see citing works
Self-citationSterling, P. (2004) · Allostasis, Homeostasis, and the Costs of Physiological Adaptation · doi:10.1017/cbo9781316257081.004 · Cited by 353 · see citing works
Cole, S. W., Hawkley, L. C., Arevalo, J. M. G., & Cacioppo, J. T. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014218108 · Cited by 306 · see citing works
Self-citationGenomic counter-stress changes induced by the relaxation response
Dusek, J. A., Otu, H. H., Wohlhueter, A. L., Bhasin, M., Zerbini, L. F., Joseph, M. G., Benson, H., & Libermann, T. A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002576 · Cited by 248 · see citing works
Biobehavioral influences on matrix metalloproteinase expression in ovarian carcinoma
Lutgendorf, S. K., Lamkin, D. M., Jennings, N. B., Arevalo, J. M. G., Penedo, F., DeGeest, K., Langley, R. R., Lucci, J. A., Cole, S. W., Lubaroff, D. M., et al. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0230 · Cited by 158 · see citing works
Self-citationSocial regulation of leukocyte homeostasis: the role of glucocorticoid sensitivity
Cole, S. W. (2008) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.02.006 · Cited by 156 · see citing works
Self-citationCole, S. W., Mendoza, S. P., & Capitanio, J. P. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181aa95a9 · Cited by 74 · see citing works
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Slavich, G. M., & Irwin, M. R. (2014) · Psychological Bulletin · doi:10.1037/a0035302 · Cited by 2,206 · see citing works
The Emerging Field of Human Social Genomics
Slavich, G. M., & Cole, S. W. (2013) · Clinical Psychological Science · doi:10.1177/2167702613478594 · Cited by 523 · see citing works
Self-citationA functional genomic perspective on human well-being
Fredrickson, B. L., Grewen, K. M., Coffey, K. A., Algoe, S. B., Firestine, A. M., Arevalo, J. M. G., Ma, J., & Cole, S. W. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305419110 · Cited by 512 · see citing works
Self-citationCole, S. W., Hawkley, L. C., Arevalo, J. M. G., & Cacioppo, J. T. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014218108 · Cited by 306 · see citing works
Self-citation
- Authors
- Cole, S. W.
- Affiliations
- Medicine, UCLA School of Medicine
- Venue
- The Oxford Handbook of Psychoneuroimmunology
- Publisher
- Oxford University Press
- Published
- 2012-11-21
- Pages
- 254-274
- OpenAlex
- W2656317121
- Cited by
- 30
- References
- 13
- Citations by year
- 2025: 10 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 3
- FWCI
- 3.83
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Oxford University Press eBooks (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- social genomics, immune response, host defense, genetic polymorphism, social behavior
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