The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
FACTORS ASSOCIATED WITH AGE-RELATED MACULAR DEGENERATION
Abstract
Data from the first National Health and Nutrition Examination Survey collected between 1971 and 1972 were used to determine what factors are associated with the prevalence of age-related macular degeneration. The study was limited to those who were at least 45 years old at the time of the ophthalmology examination. Stratified analysis, adjusting for age, showed that education, systolic blood pressure, past history of hypertension, cerebrovascular disease, and refractive error were all associated with macular degeneration. With the exception of education, these factors remained statistically significant when simultaneously entered into a logistic regression model. The frequency of consumption of fruits and vegetables rich in vitamins A and C suggested a negative association with the prevalence of macular degeneration after stratified adjustment for age. In a logistic regression analysis, adjusting for demographic and medical factors, the inverse association of vitamin C with age-related macular degeneration was no longer present. The frequency of consumption of fruits and vegetables rich in vitamin A remained negatively correlated with age-related macular degeneration even after adjustment for demographic and medical factors.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“However, data from epidemiological studies [18][19][20][21][22][23][24][25][26] as well as small randomized clinical trials [27][28][29] do not show consistent associations between intake of antioxidants or zinc and risk of AMD.”
In the citing paper
“Results from observational studies that assessed the effect of dietary antioxidants on risk for age-related macular degeneration have been inconsistent.90–95”
From Age-related macular degeneration (2008) · cites this paper as [92]
Citations
Cites
Epidemiologic Research: Principles and Quantitative Methods.
Mayer, L. S., Kleinbaum, D. G., Kupper, L. L., & Morgenstern, H. (1984) · Journal of the American Statistical Association · doi:10.2307/2288427 · Cited by 2,905
Chi-Square Tests with One Degree of Freedom; Extensions of the Mantel- Haenszel Procedure
Mantel, N. (1963) · Journal of the American Statistical Association · doi:10.1080/01621459.1963.10500879 · Cited by 2,899
RE: “ESTIMABILITY AND ESTIMATION IN CASE-REFERENT STUDIES”
Halperin, M. (1977) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a112409 · Cited by 1,546
Senile macular degeneration: a case-control study
HYMAN, L. G., LILIENFELD, A. M., FERRIS, F. L., & FINE, S. L. (1983) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a113629 · Cited by 587
Vitamin A and retinoids in health and disease
Epstein, F. H., & Goodman, D. S. (1984) · New England Journal of Medicine · doi:10.1056/nejm198404193101605 · Cited by 553
Kahn, H. A., Leibowitz, H. M., Ganley, J. P., KINI, M. M., Colton, T., NICKERSON, R. S., & Dawber, T. R. (1977) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a112429 · Cited by 391
SENILE MACULAR DEGENERATION: REVIEW OF EPIDEMIOLOGIC FEATURES
Ferris, F. L. (1983) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a113624 · Cited by 268
Risk Factors in Age-related Maculopathy Complicated by Choroidal Neovascularization
Blumenkranz, M. S., Russell, S. R., Robey, M. G., Kott‐Blumenkranz, R., & Penneys, N. S. (1986) · Ophthalmology · doi:10.1016/s0161-6420(86)33702-3 · Cited by 201
Statistics on Blindness in the Model Reporting Area 1969–1970
Kahn, H. A., & DHEW, H. B. M.-H. (1973) · Optometry and Vision Science · doi:10.1097/00006324-197312000-00022 · Cited by 193
Oxygen toxicity: membrane damage by free radicals.
Feeney, L., & Berman, E. R. (1976) · PubMed · Cited by 148
Cited by
Sorted by citations
Items 301–384 of 384
Epidemiology and Risk Factors for Age-Related Macular Degeneration
Seddon, J. M., & Sobrin, L. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4557-0737-9.00063-1 · Cited by 3
Pinazo-Duran, M. D., García‐Medina, J. J., Sanz-Gonzalez, S. M., O’Connor, J., Casaroli-Marano, R. P., Valero-Velló, M., López-Gálvez, M., Peris‐Martínez, C., Zanón‐Moreno, V., & Díaz-Llopis, M. (2021) · Diagnostics · doi:10.3390/diagnostics11040724 · Cited by 3
Dégénérescence maculaire liée à l’âge et risque d’accident vasculaire cérébral
Biousse, V., Bousser, M., & Gaudric, A. (2008) · Journal Français d Ophtalmologie · doi:10.1016/s0181-5512(08)70343-7 · Cited by 3
Cataract, Age-Related Macular Degeneration, and Primary Open-Angle Glaucoma: Risk Factors
de Jong, P. T. V. M. (2013) · Essentials in ophthalmology/Essentials ophthalmology · doi:10.1007/978-3-642-36324-5_4 · Cited by 3
Falsini, B., Piccardi, M., Minnella, A. M., Savastano, M. C., Capoluongo, E., Fadda, A., Balestrazzi, E., Maccarone, R., & Bisti, S. (2010) · Investigative Ophthalmology & Visual Science · Cited by 3
Demography and Epidemiology of Age-Associated Neuronal Impairment
Cassel, C. K., & Ek, K. (2001) · Elsevier eBooks · doi:10.1016/b978-012351830-9/50006-8 · Cited by 3
New therapies for the treatment of age-related macular degeneration
Sarrafizadeh, R., & Trese, M. T. (2000) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.10.3.333 · Cited by 3
The Relationship Between Nutritional Factors and Age-Related Macular Degeneration
Hung, S., & Seddon, J. M. (1997) · Humana Press eBooks · doi:10.1007/978-1-4757-6242-6_13 · Cited by 3
Hypermetropia as a Risk Factor for Age-Related Macular Degeneration. Review
Лихванцева, В. Г., Kapkova, S. G., Gevorgyan, A. S., & Nekrasova, E. Y. (2022) · Ophthalmology in Russia · doi:10.18008/1816-5095-2022-2-255-264 · Cited by 2
Current Views on Chr10q26 Contribution to Age-Related Macular Degeneration
Gogna, N., Hyde, L. F., Collin, G. B., Stone, L. V., Naggert, J. Κ., & Nishina, P. M. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-27681-1_5 · Cited by 2
Healthy improvement of ionic balance with industrial processing of vegetables
Martínez‐Tomé, M., & Vera, A. (2004) · Nutrition Bulletin · doi:10.1111/j.0141-9684.2003.00392.x · Cited by 2
Conceitos atuais e perspectivas na prevenção da degeneração macular relacionada à idade
Torres, R. J. D. A., Précoma, D. B., Maia, M., Kaiber, F., Prim, C. R., Luchini, A., Matos, R. S., & Farah, M. E. (2008) · Revista Brasileira de Oftalmologia · doi:10.1590/s0034-72802008000300008 · Cited by 2
Hancock, R. D., & Stewart, D. (2009) · Cited by 2
Sun, Y., Cheng, H., Ma, Y., & Ye, Q. (2017) · Functional foods & nutraceuticals series · doi:10.1201/9781315369068-7 · Cited by 2
Alsaqr, A. M., Alharbi, M., Aldossary, N., Alruwished, A., Alharbi, M., Alghaib, K., Alabdulkarim, A., Alhamdan, S., Almutleb, E. S., & Abusharha, A. (2023) · Therapeutic Advances in Ophthalmology · doi:10.1177/25158414231189099 · Cited by 2
„Haben Sie ein Mittel gegen Makuladegeneration?“
Ziemssen, F., Warga, M., Bartz‐Schmidt, K. U., & Wilhelm, H. M. (2005) · Der Ophthalmologe · doi:10.1007/s00347-005-1231-5 · Cited by 2
Age-related macular degeneration : a light and electron microscopical study
van der Schaft, T. L. (1993) · Cited by 2
Bioequivalence of Provitamin A Carotenoids
Russell, R. M., & Tang, G. (2004) · Oxidative stress and disease · doi:10.1201/9780203026649.ch12 · Cited by 2
Current thinking on antioxidant nutrients
McKevith, B., Kelly, C. N. M., Stanner, S. A., Hughes, J., & Buttriss, J. (2004) · Practice Nursing · doi:10.12968/pnur.2004.15.1.11952 · Cited by 2
Zeitouny, J. (2008) · doi:10.82308/2524 · Cited by 2
Risk Profiles for Ageing Macular Disease
de Jong, P. T. V. M. (2004) · Ophthalmologica · doi:10.1159/000079462 · Cited by 2
Investigations of a possible link between age-related macular degeneration and atherosclerosis.
Sivaprasad, S. (2005) · CERES (Cranfield University) · Cited by 2
Extracts of Tomato, Carrot, or Red Sweet Pepper Protect against Lipid Peroxidation in Bovine Retina
Nakanishi‐Ueda, T., Higa, A., Aizawa, K., Inakuma, T., Ishiguro, Y., Kan, K., Ueda, T., Koide, R., Armstrong, D., & Yasuhara, H. (2002) · The Showa University Journal of Medical Sciences · doi:10.15369/sujms1989.14.153 · Cited by 1
Age-Related Macular Degeneration and its Current Treatment Strategies: An Updated Review
Gelat, B., Trivedi, K., Malaviya, P. B., Rathaur, P., Patel, B., Gelat, R., & Johar, K. (2024) · IntechOpen eBooks · doi:10.5772/intechopen.1004075 · Cited by 1
Sangani, P., Temple, S. E., Bhandary, S. K., Narayanan, R., Johnson, E. J., Das, A. V., Ali, M. H., & Takkar, B. (2024) · Translational Vision Science & Technology · doi:10.1167/tvst.13.3.20 · Cited by 1
AMD: Epidemiology and Risk Factors
Khan, J. C. (2013) · InTech eBooks · doi:10.5772/55234 · Cited by 2
Trace Elements, Vitamins, and Lipids and Age-Related Macular Degeneration
Buitendijk, G. H. S., & Klaver, C. C. W. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-401717-7.00006-x · Cited by 1
Age-related macular disease : studies on incidence, risk factors, and prognosis
van Leeuwen, R. (2003) · Cited by 1
Epidemiology of Age-Related Macular Degeneration Early in the 21st Century
Wang, J. J., Mitchell, P., & Klein, R. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-186-4_2 · Cited by 1
Epidemiology and Risk Factors in Age-Related Macular Degeneration (AMD)
Davoudi, S., & Sobrin, L. (2022) · Springer eBooks · doi:10.1007/978-3-030-42634-7_124 · Cited by 1
Kaji, Y., Oshika, T., & Fujii, N. (2012) · InTech eBooks · doi:10.5772/31964 · Cited by 1
Johnson, E. J. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-385-5_6 · Cited by 1
Ophthalmology update for the primary practitioner
Sarrafizadeh, R., & Trese, M. T. (2000) · Disease-a-Month · doi:10.1016/s0011-5029(00)90014-2 · Cited by 1
The renin-angiotensin system antagonism in the treatment of hypertension
Bisognano, J. D., & Cody, R. J. (1999) · Current Hypertension Reports · doi:10.1007/s11906-999-0033-6 · Cited by 1
Age-Related Macular Degeneration and Vision Impairment
Wright, C. B., & Ambati, J. (2015) · Springer eBooks · doi:10.1007/978-3-319-23246-1_16 · Cited by 1
Capurso, A., Crepaldi, G., & Capurso, C. A. (2018) · Practical issues in geriatrics · doi:10.1007/978-3-319-78084-9_9 · Cited by 1
LIPID PEROXIDATION AND RETINAL PIGMENT EPITHELIUM: A REVIEW ARTICLE
Gelat, B., Malaviya, P. B., Rathaur, P., Patel, B., & Johar, K. (2022) · Towards Excellence · doi:10.37867/te1403103 · Cited by 1
Likhvantseva, V. G., Gevorgyan, A. S., Kapkova, S. G., Рычкова, С. И., & Borisenko, T. E. (2024) · Ophthalmology in Russia · doi:10.18008/1816-5095-2024-1-117-127 · Cited by 1
Consumption of Carotenoid-Rich Foods and Central Vision Loss
Holcomb, C. A. (2004) · Journal of Nutrition for the Elderly · doi:10.1300/j052v24n01_01 · Cited by 1
Hiscox, R. (2013) · ORCA Online Research @Cardiff (Cardiff University) · Cited by 1
Klaver, C. C. W., van Leeuwen, R., Vingerling, J. R., & de Jong, P. T. V. M. (2004) · Springer eBooks · doi:10.1007/978-3-662-05681-3_1 · Cited by 1
(2006) · Arbor Clinical Nutrition Updates · doi:10.1017/s1446545000000695 · Cited by 1
Pharmacological Approaches to Age-Related Macular Degeneration
Eter, N., Krohne, T. U., & Holz, F. G. (2005) · Springer eBooks · doi:10.1007/3-540-27272-0_10
Maculopatía relacionada con la edad. Conceptos actuales, terapéutica y rehabilitación visual
Serrano, A. P., & Bringas, A. R. (2003) · Revista Mexicana de Oftalmología
Longville, B. A. C. (2009) · Murdoch University Research Portal
Is Lutein a Physiologically Important Ligand for Transthyretin in Humans?
Ames Lab., A., Chen, L., & USDOE Office of Science (SC) (2003) · OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) · doi:10.2172/815752
Scanlon, G. (2011) · Arrow - TU Dublin (Technological University Dublin) · doi:10.21427/d7sp54
Kumar, K., Barguja, P., V., S. G. S. R. R., & Kubrey, S. S. (2013) · Journal of Evolution of Medical and Dental Sciences · doi:10.14260/jemds/1490
Meletis, C. D., & Centrone, W. A. (2002) · Alternative and Complementary Therapies · doi:10.1089/10762800252909847
Age-Related Maculopathy: a biochemical and immunohistochemical study
Kliffen, M. (1996) · RePub (Erasmus University Rotterdam)
EPIDEMIOLOGY OF AGE-RELATED MACULOPATHY
Bosman, F. T. (2010)
Where Do Eggs Fit in a Heart-Healthy Diet?
Celentano, J. C. (2009) · American Journal of Lifestyle Medicine · doi:10.1177/1559827609335460
Nutritional Supplement Use and Age-Related Macular Degeneration
Lo, A., & Yeung, I. Y. L. (2012) · InTech eBooks · doi:10.5772/33893
Interferon alfa therapy for age-related macular degeneration
Reddy, U. U., & Kryzstolik, M. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005138
Alterações oculares relacionados com hipertensão, diabetes e desnutrição no idoso
Netto, A. L. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.6.2020.tde-15052020-134907
Context for Protons as Adjunctive Therapy in Neovascular Age-Related Macular Degeneration: A Review
Rice, S. R., Katz, M. S. J., & Mehta, M. P. (2016) · International Journal of Particle Therapy · doi:10.14338/ijpt-15-00019.1
degenerationblood flow in age related macular Effect of systemic hypertension on foveolar
Metelitsina, T. I., Grunwald, J. E., DuPont, J. C., & Ying, G. –. (2008)
Optimizing Nutrition to Delay Age Related Macular Degeneration
Schleicher, M. M., Whitcomb, E. A., & Taylor, A. (2015) · Springer eBooks · doi:10.1007/978-3-319-22431-2_27
AREDS Supplementation and the Progression Towards Exudative AMD
Valent, D. J., & Chew, E. Y. (2016) · Essentials in ophthalmology/Essentials ophthalmology · doi:10.1007/978-3-319-24097-8_4
Foods and Supplements in the Prevention and Treatment of Age-Related Macular Degeneration
Mares, J. A. (2008) · Elsevier eBooks · doi:10.1016/b978-1-4160-0016-7.50148-x
The Role of Nutrition in Age-Related Eye Diseases
Gopinath, B. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801816-3.00032-7
The Role of Lipids and Lipid Metabolism in Age-Related Macular Degeneration
Modjtahedi, B. S., Kishan, A. U., Mathew, S. S., & Morse, L. S. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-401717-7.00007-1
Chapter 18 Nutritional Evaluation of Egg Compounds
Seuß‐Baum, I. (2007)
Vessel formation and feeder vessel treatment in choroidal neovascularization
Wolfe, J. D. (2004) · OhioLink ETD Center (Ohio Library and Information Network)
Macular pigment in monozygotic twins
Hammond, B. R. (1994) · University of New Hampshire Scholars Repository (University of New Hampshire at Manchester)
Degeneración macular asociada a la edad
Abel, R., Jr. (2009) · Elsevier eBooks · doi:10.1016/b978-84-458-1911-1.50084-1
Chen, X.-L., Hu, Q., Bai, Y., Deng, Y., Wang, H., Liu, S., Wang, Y., & Yue, Y. (2019) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-019-04377-0
RetractedPhilippou, E. (2016) · CRC Press eBooks · doi:10.1201/9781315371764-12
Lamin, A. (2019) · UCL Discovery (University College London)
Epidemiology and Risk Factors in Age-Related Macular Degeneration (AMD)
Davoudi, S., & Sobrin, L. (2020) · Springer eBooks · doi:10.1007/978-3-319-90495-5_124-1
Comparative Analysis Of The Results Of Anti-VEGF Therapy In Patients With AMD
Vidinova, H., Antonova, D., & Voynov, L. (2021) · Bulgarian Review of Ophthalmology · doi:10.14748/bro.v65i2.7825
Age-Related Macular Degeneration
(2007) · Humana Press eBooks · doi:10.1007/978-1-59259-979-0_3
Evans, J. R. (2007) · CRC Press eBooks · doi:10.1201/9781420043013.ch14
The Role of Lipids and Lipid Metabolism in Age-Related Macular Degeneration
Fortenbach, C. R., Goldman, E., Kishan, A. U., Mathew, S. S., Modjtahedi, B. S., & Morse, L. S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815245-4.00004-1
Klaver, C. C. W., Vingerling, J. R., Hofman, A., & de Jong, P. T. V. M. (1997) · Springer eBooks · doi:10.1007/978-3-662-11126-0_1
The Role of Nutrition in Healthy Aging
(2023) · Frontiers research topics · doi:10.3389/978-2-8325-4155-5
Mrugała, S., Mrugała, W., Kawka, J., Baranowska, A., Baranowska, K., Czyżewski, F., Filipek, K., Muciek, M., Skierkowski, B., & Zalewska, N. (2024) · Journal of Education Health and Sport · doi:10.12775/jehs.2024.76.56412
Kim, J. E., & Hu, W. (2025) · Springer eBooks · doi:10.1007/978-3-031-96913-3_4
Caractérisation et prévention des conséquences d'un syndrome métabolique dans la rétine
Vidal, E. (2018) · theses.fr (ABES) · doi:10.70675/09e85feez27afz465az91aaz70fa8efb0c74
Berrow, E. J. (2012) · Aston Publications Explorer (Aston University) · doi:10.48780/publications.aston.ac.uk.00016328
Metadata
- Authors
- GOLDBERG, J., FLOWERDEW, G., SMITH, E., BRODY, J. A., & TSO, M. O. M.
- Affiliations
- University of Illinois Chicago (US)
- Corresponding author
- GOLDBERG, JACK
- ORCID
- GOLDBERG, JACK
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 1988-10
- Volume
- 128
- Issue
- 4
- Pages
- 700-710
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- OpenAlex
- W2102446763
- Cited by
- 384
- References
- 18
- Citations by year
- 2025: 2 · 2024: 5 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 6 · 2019: 6 · 2018: 7 · 2017: 8 · 2016: 9 · 2015: 8 · 2014: 8 · 2013: 14 · 2012: 13
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Health Sciences › Medicine › Ophthalmology › Ophthalmology and Visual Impairment Studies
- Keywords
- age-related macular degeneration, prevalence, risk factors, systolic blood pressure, hypertension, cerebrovascular disease, refractive error, vitamin A, vitamin C, fruit and vegetable intake, older adults, NHANES
- MeSH terms
- Age Factors, Aged, Ascorbic Acid, Female, Fruit, Health Surveys, Humans, Hypertension, Macular Degeneration, Male, Middle Aged, United States, Vegetables, Vitamin A
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review