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FIELD EVALUATION OF A RESPIRATORY SYNCYTIAL VIRUS VACCINE AND A TRIVALENT PARAINFLUENZA VIRUS VACCINE IN A PEDIATRIC POPULATION1
Abstract
A field evaluation of two formalininactivated respiratory virus vaccines was conducted in a selected pediatric population in California during the 1966—1967 respiratory disease season. A total of 441 children ranging in age from four months to nine years were immunized; 219 with a respiratory syncytial (RS) virus vaccine and 222 with a trivalent parainfluenza virus (types 1, 2 and 3) vaccine. Both vaccines elicited good serum antibody responses. Very high attack rates of parainfluenza virus, types 1 and 3 and RS virus were observed during the study period in infants and children in both vaccine groups. A protective effect was not demonstrable for either vaccine. Infants who received the RS virus vaccine and who subsequently became infected with RS virus tended to have a more severe clinical illness than infants who did not receive this vaccine.
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Cited by
Chanock, R. M., Kim, H. W., Brandt, C., & Parrott, R. H. (1976) · Viral Infections of Humans · doi:10.1007/978-1-4613-3988-5_17 · Cited by 1,085
Handwashing and risk of respiratory infections: a quantitative systematic review
Rabie, T., & Curtis, V. (2006) · Tropical Medicine & International Health · doi:10.1111/j.1365-3156.2006.01568.x · Cited by 556
A perspective on potential antibody-dependent enhancement of SARS-CoV-2
Arvin, A. M., Fink, K., Schmid, M. A., Cathcart, A., Spreafico, R., Havenar-Daughton, C., Lanzavecchia, A., Corti, D., & Virgin, H. W. (2020) · Nature · doi:10.1038/s41586-020-2538-8 · Cited by 485
A proof of concept for structure-based vaccine design targeting RSV in humans
Crank, M. C., Ruckwardt, T. J., Chen, M., Morabito, K. M., Phung, E., Costner, P. J., Holman, L. A., Hickman, S. P., Berkowitz, N. M., Gordon, I. J., et al. (2019) · Science · doi:10.1126/science.aav9033 · Cited by 333
Antibody-Dependent Enhancement of Virus Infection and Disease
Tirado, S. M. C., & Yoon, K.-J. (2003) · Viral Immunology · doi:10.1089/088282403763635465 · Cited by 313
Metadata
- Authors
- CHIN, J., MAGOFFIN, R. L., SHEARER, L. A., SCHIEBLE, J. H., & LENNETTE, E. H.
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 1969-04
- Volume
- 89
- Issue
- 4
- Pages
- 449-463
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- OpenAlex
- W1913350003
- Cited by
- 630
- References
- 0
- FWCI
- 6.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: FIELD EVALUATION OF A RESPIRATORY SYNCYTIAL VIRUS VACCINE AND A TRIVALENT PARAINFLUENZA VIRUS VACCINE IN A PEDIATRIC POPULATION1. https://app.cochat.ai/papers/10.1093/oxfordjournals.aje.a120957
- The paper
- CHIN, J., MAGOFFIN, R. L., SHEARER, L. A., SCHIEBLE, J. H., & LENNETTE, E. H. (1969). FIELD EVALUATION OF A RESPIRATORY SYNCYTIAL VIRUS VACCINE AND A TRIVALENT PARAINFLUENZA VIRUS VACCINE IN A PEDIATRIC POPULATION1. American Journal of Epidemiology. https://doi.org/10.1093/oxfordjournals.aje.a120957
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
