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THROMBOEMBOLISM AND ORAL CONTRACEPTIVERS: AN EPIDEMIOLOGIC CASE-CONTROL STUDY12
Abstract
A retrospective study was conducted of thromboembolism by interviewing 175 married and unmarried women aged 15-44 discharged alive within 3 years from 43 hospitals in 5 U.S. cities. Thromboembolism included venous or arterial thrombosis with or without pulmonary embolism cerebral and coronary thrombosis and pulmonary embolism without a known source. 175 hospital controls were matched pairwise with cases on hospital residence time of hospitalization race age marital status parity and pay status. Both groups were free of obesity chronic conditions associated with thromboembolism and contraindications to pregnancy and were presumably fertile. 67 cases and 23 controls had used oral contraceptives until 1 month before entering hospital; 11 cases and controls had discontinued pills earlier. Duration of use did not affect risk. There were 57 case-control pairs in which only the case had used pills compared to 13 pairs in which only the control had used pills. The relative risk of thromboembolism for users was estimated to be 4.4 times that for nonusers. The risk was higher for sequential pill users. 25% of the cases were attributable to oral contraceptives.(Authors modified)
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Citations
Cited by
World Health Organization Collaborative Study of Cardiovascular Disease and Steroid Hormone Contarception (1995) · The Lancet · doi:10.1016/s0140-6736(95)91926-0 · Cited by 631
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Loprinzi, C. L., Michalak, J. C., Quella, S. K., O'Fallon, J. R., Hatfield, A. K., Nelimark, R. A., Dose, A. M., Fischer, T., Johnson, C., Klatt, N. E., et al. (1994) · New England Journal of Medicine · doi:10.1056/nejm199408113310602 · Cited by 500
Oral Contraceptives and Cardiovascular Disease
Stadel, B. V. (1981) · New England Journal of Medicine · doi:10.1056/nejm198109103051104 · Cited by 494
Stegeman, B. H., de Bastos, M., Rosendaal, F. R., van Hylckama Vlieg, A., Helmerhorst, F. M., Stijnen, T., & Dekkers, O. M. (2013) · BMJ · doi:10.1136/bmj.f5298 · Cited by 420
Huisman, M. V., Barco, S., Cannegieter, S. C., Le Gal, G., Konstantinides, S. V., Reitsma, P. H., Rodger, M., Noordegraaf, A. V., & Klok, F. A. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2018.28 · Cited by 336
Metadata
- Authors
- SARTWELL, P. E., MASI, A. T., ARTHES, F. G., GREENE, G. R., & SMITH, H. E.
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 1969-11
- Volume
- 90
- Issue
- 5
- Pages
- 365-380
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- OpenAlex
- W2254262160
- Cited by
- 342
- References
- 0
- FWCI
- 24.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: THROMBOEMBOLISM AND ORAL CONTRACEPTIVERS: AN EPIDEMIOLOGIC CASE-CONTROL STUDY12. https://app.cochat.ai/papers/10.1093/oxfordjournals.aje.a121082
- The paper
- SARTWELL, P. E., MASI, A. T., ARTHES, F. G., GREENE, G. R., & SMITH, H. E. (1969). THROMBOEMBOLISM AND ORAL CONTRACEPTIVERS: AN EPIDEMIOLOGIC CASE-CONTROL STUDY12. American Journal of Epidemiology. https://doi.org/10.1093/oxfordjournals.aje.a121082
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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