Venous thromboembolic disease and combined oral contraceptives: results of international multicentre case-control study

World Health Organization Collaborative Study of Cardiovascular Disease and Steroid Hormone Contarception

doi:10.1016/s0140-6736(95)91926-0

Cited by 631Venous Thromboembolism Diagnosis and ManagementBlood Coagulation and Thrombosis MechanismsCerebral Venous Sinus Thrombosis

Venous thromboembolic disease and combined oral contraceptives: results of international multicentre case-control study

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World Health Organization Collaborative Study of Cardiovascular Disease and Steroid Hormone Contarception·1995·The Lancet

DOI 10.1016/s0140-6736(95)91926-0

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The most common clinical presentation of estrogen-related thrombosis is venous thromboembolism of the deep veins of the legs or pulmonary vessels, usually within the first few months of use.
“The most common clinical presentation of estrogen-related thrombosis is venous thromboembolism (VTE) of the deep veins of the legs or pulmonary vessels, usually within the first few months of use.”
From Estrogen and thrombosis: a bench to bedside review (2020) · cites this paper as [100]
In an international case-control study across 21 centers, the World Health Organization reported in 1995 that increased risk of VTE was apparent within 4 months of starting CHCs, was unaffected by the duration of current type of CHC use, and returned to baseline within 3 months of discontinuing CHCs.
“In an international case-control study across 21 centers, the World Health Organization reported in 1995 that increased risk of VTE was apparent within 4 months of starting CHCs, was unaffected by the duration of current type of CHC use, and returned to baseline within 3 months of discontinuing CHCs [100].”
From Estrogen and thrombosis: a bench to bedside review (2020) · cites this paper as [100]
In patients with thrombosis provoked by hormonal contraception, the risk of recurrence returns to baseline within one to three months of cessation of hormonal use.
“In patients with thrombosis provoked by hormonal contraception, the risk is believed to return to baseline levels within one to three months of cessation of hormonal use [100, 107].”
From Estrogen and thrombosis: a bench to bedside review (2020) · cites this paper as [100]

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Authors: World Health Organization Collaborative Study of Cardiovascular Disease and Steroid Hormone Contarception
Venue: The Lancet
Publisher: Elsevier BV
Published: 1995-12
Volume: 346
Issue: 8990
Pages: 1575-1582
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(95)91926-0
OpenAlex: W4247374640
Cited by: 631
References: 40
Citations by year: 2026: 6 · 2025: 6 · 2024: 6 · 2023: 6 · 2022: 9 · 2021: 5 · 2020: 15 · 2019: 6 · 2018: 8 · 2017: 14 · 2016: 17 · 2015: 18 · 2014: 18 · 2013: 22 · 2012: 20
FWCI: 34.35
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
PubMed
Topics: Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
Health Sciences › Medicine › Neurology › Cerebral Venous Sinus Thrombosis
Keywords: venous thromboembolism, combined oral contraceptives, thrombosis risk, oral contraceptive use, case-control study
MeSH terms: Adult, Contraceptives, Oral, Combined, Developing Countries, Europe, Female, Humans, Progestins, Pulmonary Embolism, Risk Factors, Thromboembolism, Thrombophlebitis, Time Factors, Body Mass Index, Odds Ratio, Case-Control Studies

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