The immature skin
Abstract
The infant below 28 weeks gestation is born with an immature skin with a poorly formed epidermal barrier, although rapid postnatal maturation occurs over the first two weeks of life. This leads to a high transepidermal water loss with consequent difficulties in fluid balance and temperature control, accidental poisioning from percutaneous absorption of chemicals, and surperficial damage from use of adhesives in neonatal care. Percutaneous respiration occurs more readily than at term and may be of benefit. Immaturity of the dermis and the associated skin appendages is not of major clinical significance.
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Removal of adhesives necessary for securing medical equipment poses a greater risk with greater prematurity, where up to 15% of a neonate's total skin surface area can be traumatized daily.
“As a result, removal of adhesives necessary for securing medical equipment poses a greater risk with greater prematurity, where up to 15% of a neonate’s total skin surface area can be traumatized daily (21).”
From Binodal, wireless epidermal electronic systems with in-sensor analytics for neonatal intensive care (2019) · cites this paper as [21]
Cites
Barrier properties of the newborn infant's skin
Harpin, V., & Rutter, N. (1983) · The Journal of Pediatrics · doi:10.1016/s0022-3476(83)80669-6 · Cited by 328 · see citing works
Self-citationTRANSEPIDERMAL WATER LOSS IN NEWBORN INFANTS
Hammarlund, K., & Sedin, G. (2008) · Acta Paediatrica · doi:10.1111/j.1651-2227.1979.tb08214.x · Cited by 317 · see citing works
Development of the Epidermis in the Newborn
Evans, N. J., & Rutter, N. (2009) · Biology of the Neonate · doi:10.1159/000242513 · Cited by 305 · see citing works
Self-citationPercutaneous Drug Absorption in the Newborn: Hazards and Uses
Rutter, N. (1987) · Clinics in Perinatology · doi:10.1016/s0095-5108(18)30740-1 · Cited by 104 · see citing works
Self-citationSemipermeable Polyurethane Membrane as an Artificial Skin for the Premature Neonate
Knauth, A. L., Gordin, M. D., McNelis, W., et al. (1989) · PEDIATRICS · doi:10.1542/peds.83.6.945 · Cited by 82 · see citing works
Baumgart, S. (1984) · PEDIATRICS · doi:10.1542/peds.74.6.1022 · Cited by 64 · see citing works
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Binodal, wireless epidermal electronic systems with in-sensor analytics for neonatal intensive care
Chung, H. U., Kim, B. H., Lee, J. Y., Lee, J., Xie, Z., Ibler, E. M., Lee, K., Banks, A., Jeong, J. Y., Kim, J., et al. (2019) · Science · doi:10.1126/science.aau0780 · Cited by 807 · see citing works
Xu, S., Rwei, A. Y., Vwalika, B., Chisembele, M. P., Stringer, J. S. A., Ginsburg, A. S., & Rogers, J. A. (2021) · The Lancet Digital Health · doi:10.1016/s2589-7500(21)00001-7 · Cited by 57 · see citing works
- Authors
- Rutter, N.
- Affiliations
- University of Nottingham (GB)
- Corresponding author
- Rutter, N
- ORCID
- Rutter, N
- Venue
- British Medical Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 1988
- Volume
- 44
- Issue
- 4
- Pages
- 957-970
- ISSN
- 0007-1420 (ISSN-L)
- 1471-8391
- OpenAlex
- W2395185260
- Cited by
- 47
- References
- 6
- Citations by year
- 2021: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 1 · 2012: 2
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- British Medical Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Health Professions › Speech and Hearing › Neonatal skin health care
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- neonatal skin, skin barrier, transepidermal water loss, fluid balance, thermoregulation, percutaneous absorption, dermis, skin appendages
- MeSH terms
- Humans, Infant, Newborn, Infant, Premature, Skin, Skin Absorption, Skin Physiological Phenomena, Water Loss, Insensible
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