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Cited by 24Electrolyte and hormonal disordersHypothalamic control of reproductive hormonesPregnancy and preeclampsia studies

Endocrinology: Vasopressin and atrial natriuretic hormone response to hypertonic saline during the follicular and luteal phases of the menstrual cycle

Trigoso, W. F., Wesly, J. M., Meranda, D. L., Shenker, Y.·1996·Human Reproduction
DOI 10.1093/oxfordjournals.humrep.a019121
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Abstract

We studied the hormonal responses to hypertonic saline during the follicular (days 2-9) and luteal (days 21-28) phases of the menstrual cycle in nine healthy young women, aged 19-25 years. On both study days, each woman was infused with 5% hypertonic saline for 1 h at the rate of 0.1 ml/kg/min. Serum progesterone and oestradiol concentrations confirmed the reported stage of the menstrual cycle. No difference in weight or haematocrit was observed between the two stages of the study for each woman. Baseline blood pressure, serum sodium, plasma osmolality, plasma vasopressin and thirst levels were almost identical for both stages, and changed to the same degree during infusion of hypertonic saline. Baseline atrial natriuretic hormone concentrations were higher during the follicular phase and became significantly higher than during the luteal phase following infusion of hypertonic saline. We concluded that the intravascular volume during the luteal phase may be effectively decreased in comparison to the follicular phase.

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  • Changes in body fluid regulation may be due to changes in the osmotic regulation of AVP and thirst sensation.

    “One proposed mechanism for these changes in body fluid regulation may be due to changes in the osmotic regulation of arginine vasopressin (AVP) and thirst sensation (27,35,37).”

    From Progesterone does not alter osmotic regulation of AVP (2001) · cites this paper as [35]

    The Introduction (p. 1) proposes hormonal changes, including vasopressin, as contributors to menstrual-cycle changes in fluid balance. The Discussion (p. 3) reports a lower luteal-phase osmotic threshold for vasopressin that approached significance, but the Results (p. 2) found no significant difference in the thirst threshold between phases. The proposed change in osmotic regulation of thirst is therefore not supported by this paper. (LLM, conf=0.86)

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  • An earlier study demonstrated a nonstatistically significant 3 mosmol/kgH2O fall in thirst onset during osmotic stimulation between the follicular and luteal phases of women with normal menstrual cycles.

    “Moreover, an earlier study also demonstrated a nonstatistically significant 3 mosmol/kgH 2 O fall in thirst onset during osmotic stimulation between the follicular and luteal phases of women with normal menstrual cycles (35).”

    From Progesterone does not alter osmotic regulation of AVP (2001) · cites this paper as [35]

    The Results (p. 2) say the threshold for thirst was not significantly different between phases. Table I (p. 1) gives thirst intercepts of 269.2 and 264.4 mOsm/kg, a fall of about 4.8—not 3.1 mOsm/kg. The approximately 3 mOsm/kg fall reported in the Results refers to the vasopressin-secretion threshold, not thirst onset. (LLM, conf=0.90)

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Authors
Trigoso, W. F., Wesly, J. M., Meranda, D. L., & Shenker, Y.
Affiliations
  • Springfield Clinic (US)
  • William S. Middleton Memorial Veterans Hospital (US)
  • University of Wisconsin–Madison (US)
Venue
Human Reproduction
Publisher
Oxford University Press (OUP)
Published
1996-11-01
Volume
11
Issue
11
Pages
2392-2395
ISSN
  • 0268-1161 (ISSN-L)
  • 1460-2350
DOI
10.1093/oxfordjournals.humrep.a019121
OpenAlex
W2106859978
Cited by
24
References
20
Citations by year
2025: 1 · 2018: 1 · 2014: 1 · 2012: 1
FWCI
2.42
Type
journal article
Language
en
Open access
closed
Locations
  • Human Reproduction (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Center for Research Resources (RR03186)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Electrolyte and hormonal disorders
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Keywords
vasopressin, atrial natriuretic peptide, hypertonic saline, menstrual cycle, follicular phase, luteal phase, plasma osmolality, thirst, intravascular volume, serum sodium, blood pressure
MeSH terms
Adult, Blood Pressure, Estradiol, Female, Follicular Phase, Humans, Kinetics, Luteal Phase, Atrial Natriuretic Factor, Osmolar Concentration, Progesterone, Saline Solution, Hypertonic, Sodium, Thirst, Vasopressins

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