Prognostic value of two putative sperm function tests: Hypo-osmotic swelling and bovine sperm mucus penetration test (Penetrak)
Abstract
The clinical value of two inexpensive and easy to perform sperm function tests (hypo-osmotic swelling and bovine sperm mucus penetration tests) were examined in a prospective study of in-vivo conception rates in 325 couples. Both tests were of no significant value alone or in combination with traditional semen characteristics in predicting pregnancy outcome. The two most predictive factors of conception were the length of infertility and percentage of progressively motile spermatozoa. Our data support the further investigation of sperm function using more sophisticated quantitative tests, specifically the examination of sperm motility.
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The WHO manual cites older papers stating that rapid motility (grade a) has clinical value.
“To justify this choice, the WHO manual cites older papers stating that rapid motility (grade a) has clinical value [21,22,23,24,25,26,27,28,29,30].”
From The Sixth Edition of the WHO Manual for Human Semen Analysis: A Critical Review and SWOT Analysis (2021) · cites this paper as [23]
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- Authors
- Barratt, C. L. R., McLeod, I. D., Dunphy, B. C., & Cooke, I. D.
- Affiliations
- Jessop Hospital (GB)
- Corresponding author
- Barratt, C.L.R.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 1992-10
- Volume
- 7
- Issue
- 9
- Pages
- 1240-1244
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2256444911
- Cited by
- 37
- References
- 0
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 1 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 2
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Discovery Research Portal (University of Dundee) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Health Professions › General Health Professions › Male Reproductive Health Studies
- Keywords
- sperm function tests, hypo-osmotic swelling test, male infertility, sperm motility, infertility duration, pregnancy outcome prediction, semen parameters
- MeSH terms
- Adult, Cervix Mucus, Female, Follow-Up Studies, Humans, Infertility, Male, Male, Middle Aged, Osmosis, Predictive Value of Tests, Pregnancy, Prospective Studies, Regression Analysis, Sperm Count, Sperm Motility, Spermatozoa, Life Tables
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