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Protein Kinase C (PKC ): Regulation and Biological Function
Abstract
Protein kinase C alpha (PKC alpha) is a serine/threonine kinase and a member of the conventional (classical) PKCs (cPKCs), which have four conserved (C1 to C4) regions. This ubiquitously expressed PKC isotype is activated in response to many different kinds of stimuli and translocates from cytosol to the specialized cellular compartments (nucleus, focal adhesion, caveolae, etc.) where it is presumed to work. Therefore, PKC alpha has been implicated in a variety of cellular functions including proliferation, apoptosis, differentiation, motility, and inflammation. However, the responses induced by activation or overexpression of PKC alpha vary depending on the types, and sometimes conditions, of cells. For example, in some types of cells, PKC alpha is implicated in cell growth. In contrast, it may play a role in cell cycle arrest and differentiation in other types of cells. Therefore, alterations of cell responses induced by PKC alpha are not an intrinsic property of this isoform. The responses are modulated by dynamic interactions with cell-type specific factors: substrates, modulators and anchoring proteins.
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Cited by
Sarbassov, D. D., Ali, S. M., Kim, D.-H., Guertin, D. A., Latek, R. R., Erdjument-Bromage, H., Tempst, P., & Sabatini, D. M. (2004) · Current Biology · doi:10.1016/j.cub.2004.06.054 · Cited by 2,665
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Distinguishing features of microglia- and monocyte-derived macrophages after stroke
Kronenberg, G., Uhlemann, R., Richter, N., Klempin, F., Wegner, S., Staerck, L., Wolf, S., Uckert, W., Kettenmann, H., Endres, M., et al. (2018) · Acta Neuropathologica · doi:10.1007/s00401-017-1795-6 · Cited by 111
Martin, E. C., Elliott, S., Rhodes, L. V., Antoon, J. W., Fewell, C., Zhu, Y., Driver, J. L., Jodari‐Karimi, M., Taylor, C. W., Flemington, E. K., et al. (2014) · Molecular Carcinogenesis · doi:10.1002/mc.21946 · Cited by 54
Elisia, I., & Kitts, D. D. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00269.2013 · Cited by 19
Metadata
- Authors
- Nakashima, S.
- Venue
- Journal of Biochemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-11-01
- Volume
- 132
- Issue
- 5
- Pages
- 669-675
- ISSN
- 0021-924X (ISSN-L)
- OpenAlex
- W2325747908
- Cited by
- 278
- References
- 0
- FWCI
- 4.32
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
