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Prokaryotic Evolution in Light of Gene Transfer
Abstract
Accumulating prokaryotic gene and genome sequences reveal that the exchange of genetic information through both homology-dependent recombination and horizontal (lateral) gene transfer (HGT) is far more important, in quantity and quality, than hitherto imagined. The traditional view, that prokaryotic evolution can be understood primarily in terms of clonal divergence and periodic selection, must be augmented to embrace gene exchange as a creative force, itself responsible for much of the pattern of similarities and differences we see between prokaryotic microbes. Rather than replacing periodic selection on genetic diversity, gene loss, and other chromosomal alterations as important players in adaptive evolution, gene exchange acts in concert with these processes to provide a rich explanatory paradigm-some of whose implications we explore here. In particular, we discuss (1) the role of recombination and HGT in giving phenotypic "coherence" to prokaryotic taxa at all levels of inclusiveness, (2) the implications of these processes for the reconstruction and meaning of "phylogeny," and (3) new views of prokaryotic adaptation and diversification based on gene acquisition and exchange.
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“The recognition that substantial horizontal gene transfer (HGT) has occurred between microorganisms raised concerns that genes might be transferred with high enough frequency as to seriously challenge the notion of a universal tree of life (e.g.Doolittle 1999; Gogarten et al. 2002).”
From The Emergence of Life (2019) · cites this paper as Gogarten et al. 2002
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Metadata
- Authors
- Gogarten, J. P., Doolittle, W. F., & Lawrence, J. G.
- Affiliations
- University of Connecticut (US)
- Venue
- Molecular Biology and Evolution
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-12-01
- Volume
- 19
- Issue
- 12
- Pages
- 2226-2238
- ISSN
- 0737-4038 (ISSN-L)
- 1537-1719
- OpenAlex
- W2110105435
- Cited by
- 986
- References
- 132
- Citations by year
- 2026: 16 · 2025: 16 · 2024: 19 · 2023: 18 · 2022: 27 · 2021: 31 · 2020: 37 · 2019: 31 · 2018: 33 · 2017: 32 · 2016: 45 · 2015: 39 · 2014: 47 · 2013: 57 · 2012: 51
- FWCI
- 16.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Biology and Evolution (publishedVersion)
- PubMed (publishedVersion)
- Funders
- David and Lucile Packard Foundation
- National Aeronautics and Space Administration
- Canadian Institute for Advanced Research
- Canada Research Chairs
- Health Canada
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- prokaryotic evolution, horizontal gene transfer, homologous recombination, genetic exchange, phylogeny, diversification, gene loss, clonal divergence
- MeSH terms
- Phylogeny, Prokaryotic Cells, Evolution, Molecular, Gene Transfer, Horizontal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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