The origin and evolution of Ebola and Marburg viruses
Abstract
Molecular evolutionary analyses for Ebola and Marburg viruses were conducted with the aim of elucidating evolutionary features of these viruses. In particular, the rate of nonsynonymous substitutions for the glycoprotein gene of Ebola virus was estimated to be, on the average, 3.6 x 10(-5) per site per year. Marburg virus was also suggested to be evolving at a similar rate. Those rates were a hundred times slower than those of retroviruses and human influenza A virus, but were of the same order of magnitude as that of the hepatitis B virus. When these rates were applied to the degree of sequence divergence, the divergence time between Ebola and Marburg viruses was estimated to be more than several thousand years ago. Moreover, most of the nucleotide substitutions were transitions and synonymous for Marburg virus. This suggests that purifying selection has operated on Marburg virus during evolution.
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Three studies reported molecular evolutionary rates of MV, two estimated using whole genome sequencing and one based on individual genes.
“Three studies reported molecular evolutionary rates of MV, two estimated using whole genome sequencing (32,33) and one based on individual genes (34).”
From Marburg virus disease outbreaks, mathematical models, and disease parameters: a systematic review (2024) · cites this paper as [34]
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- Authors
- Suzuki, Y., & Gojobori, T.
- Affiliations
- National Institute of Genetics (JP)
- Venue
- Molecular Biology and Evolution
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-08-01
- Volume
- 14
- Issue
- 8
- Pages
- 800-806
- ISSN
- 0737-4038 (ISSN-L)
- 1537-1719
- OpenAlex
- W2121586109
- Semantic Scholar
- 84b21893b7d878d9111c32cb040e7e5af019cceb
- Cited by
- 108
- References
- 37
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 6 · 2016: 2 · 2015: 17 · 2014: 9 · 2013: 2 · 2012: 7
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Biology and Evolution (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Eye Institute
- Topics
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Outbreaks Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Keywords
- Ebola virus, Marburg virus, molecular evolution, nonsynonymous substitution rate, glycoprotein gene, divergence time estimation, purifying selection, nucleotide substitution patterns, sequence divergence
- MeSH terms
- DNA, Viral, Genes, Viral, Molecular Sequence Data, Mutation, Viral Proteins, Viral Structural Proteins, Filoviridae, Evolution, Molecular, Marburgvirus, Ebolavirus
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