A comparison of the small ribosomal RNA genes from the mitochondrial DNA of the great apes and humans: sequence, structure, evolution, and phylogenetic implications.

James E. Hixson; Wesley M. Brown

doi:10.1093/oxfordjournals.molbev.a040379

Cited by 210Genomics and Phylogenetic StudiesRNA and protein synthesis mechanismsChromosomal and Genetic Variations

A comparison of the small ribosomal RNA genes from the mitochondrial DNA of the great apes and humans: sequence, structure, evolution, and phylogenetic implications.

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James E. Hixson, Wesley M. Brown·1986·Molecular Biology and Evolution

DOI 10.1093/oxfordjournals.molbev.a040379

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Abstract

Restriction endonuclease fragments produced by EcoRI/AvaI or KpnI digestion and containing the small (12S) ribosomal RNA (rRNA) genes from the mitochondrial DNAs (mtDNAs) of the common chimpanzee, pygmy chimpanzee, gorilla, and orangutan were inserted into the plasmids pBR322 or pADD1. After species verification the inserted fragments were digested with SauIIIA, subcloned into M13mp7 vectors, and sequenced. The small rRNA gene sequences were compared with each other and with the published human sequence (Anderson et al. 1981). Substitutions were detected at 118 of the 955 nucleotide positions compared. Pairwise, the sequence differences ranged from 1% (between the chimpanzee species) to 9% (comparisons involving the orangutan); the proportion that were transitions ranged from 87% to 100%. Deletions and/or additions were noted at seven locations. With respect to evolutionary sequence lability, kinetic analysis indicated the presence of at least two classes of nucleotide positions; the more labile class occurs in sequences thought to form self-complementary duplexes (stems) in the mature rRNA. The high frequency of compensating substitutions, which maintain base-pairing within these sequences, corroborates their inferred structure. Phylogenetic inferences drawn from the sequence comparisons support the notion of an approximately equidistant relationship among chimpanzees, gorilla, and man, with the orangutan much less closely related. However, inference from a shared deletion suggests that the gorilla and the chimpanzees may be more closely related to one another than they are to man.

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In vertebrate mt-rDNA as well as in nuclear rDNA, transversions tend to occur much less frequently than transitions.
“In vertebrate mt-rDNA (Hixson and Brown 1986) as well as in nuclear rDNA (Larson and Wilson 1989;Hedges et al. 1990), transversions tend to occur much less frequently than transitions.”
From Phylogeny of the Bovidae (Artiodactyla, Mammalia), based on mitochondrial ribosomal DNA sequences. (1992) · cites this paper as Hixson and Brown 1986

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Authors: Hixson, J. E., & Brown, W. M.
Affiliations: University of Michigan (US)
ORCID: James E. Hixson
Venue: Molecular Biology and Evolution
Publisher: Oxford University Press (OUP)
Published: 1986-01
Volume: 3
Issue: 1
Pages: 1-18
ISSN: 0737-4038 (ISSN-L)
1537-1719
DOI: 10.1093/oxfordjournals.molbev.a040379
OpenAlex: W2101293289
Cited by: 210
References: 50
Citations by year: 2025: 1 · 2024: 1 · 2023: 2 · 2021: 1 · 2020: 4 · 2018: 3 · 2017: 3 · 2016: 2 · 2014: 2 · 2013: 5 · 2012: 2
FWCI: 6.06
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Molecular Biology and Evolution (publishedVersion)
PubMed (publishedVersion)
Funders: Cancer Research Institute
University of Michigan
U.S. Public Health Service
National Institute of General Medical Sciences (GM-30144, GM-07544)
National Center for Research Resources (RR 07050)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
Keywords: mitochondrial DNA, great apes, human, chimpanzees, bonobos, gorillas, orangutans, sequence comparison, nucleotide substitution, base pairing, secondary structure, phylogenetic relationships
MeSH terms: Animals, Base Sequence, Cloning, Molecular, DNA, Mitochondrial, DNA, Ribosomal, Genes, Humans, Hydrogen Bonding, Molecular Sequence Data, Nucleic Acid Conformation, RNA, Ribosomal, Hominidae

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A comparison of the small ribosomal RNA genes from the mitochondrial DNA of the great apes and humans: sequence, structure, evolution, and phylogenetic implications.

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