The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
The rate of synonymous substitution in enterobacterial genes is inversely related to codon usage bias.
Open accessAbstract
Genes sequences from Escherichia coli, Salmonella typhimurium, and other members of the Enterobacteriaceae show a negative correlation between the degree of synonymous-codon usage bias and the rate of nucleotide substitution at synonymous sites. In particular, very highly expressed genes have very biased codon usage and accumulate synonymous substitutions very slowly. In contrast, there is little correlation between the degree of codon bias and the rate of protein evolution. It is concluded that both the rate of synonymous substitution and the degree of codon usage bias largely reflect the intensity of selection at the translational level. Because of the high variability among genes in rates of synonymous substitution, separate molecular clocks of synonymous substitution might be required for different genes.
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Cites
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Cited by
Correlation of mRNA and protein in complex biological samples
Maier, T., Güell, M., & Serrano, L. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.10.036 · Cited by 1,802
Lee, H., Popodi, E., Tang, H., & Foster, P. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1210309109 · Cited by 681
Physical limits of cells and proteomes
Dill, K. A., Ghosh, K., & Schmit, J. D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114477108 · Cited by 298
Synonymous Codon Usage in Escherichia coli: Selection for Translational Accuracy
Stoletzki, N., & Eyre-Walker, A. (2006) · Molecular Biology and Evolution · doi:10.1093/molbev/msl166 · Cited by 339
An Evaluation of Measures of Synonymous Codon Usage Bias
Comeron, J. M., & Aguadé, M. (1998) · Journal of Molecular Evolution · doi:10.1007/pl00006384 · Cited by 337
Metadata
- Venue
- Molecular Biology and Evolution
- Publisher
- Oxford University Press (OUP)
- Published
- 1987-05
- Volume
- 4
- Issue
- 3
- Pages
- 222-30
- ISSN
- 0737-4038 (ISSN-L)
- 1537-1719
- OpenAlex
- W1951333111
- Cited by
- 347
- References
- 19
- FWCI
- 3.17
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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