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Maternal depression and child development
Open accessAbstract
Maternal depression is considered a risk factor for the socioemotional and cognitive development of children [1]. The current prevalence of depression in Canada averages at 6%, which is similar to the rates in other western countries [2] (the female-to-male ratio average is 2:1 [3]). However, the prevalence of postpartum depression is approximately 13% [4]. Women of childbearing age are particularly at risk for depression, and many of them experience high levels of social morbidity and depressive symptoms that are often unrecognized and untreated. Mothers already at risk for depression are particularly fragile during the first months postpartum. Maternal depression has consequences on the child’s development. Because physicians who care for infants and children encounter mothers repeatedly, it is important that they have the knowledge and skills for the detection of symptoms of maternal depression. The objectives of this statement are: To review the present knowledge on the consequences of maternal depression on the development of children at various ages; To review the evidence-based literature on the treatment of maternal depression and its impact on newborns, infants and children; and To review the role of the child’s physician in the detection of symptoms of maternal depression, and the coordination of appropriate support and management. A literature search for the past 15 years was conducted using the MEDLINE database, and by reviewing the bibliographies of the retrieved articles. Of particular interest were the prospective longitudinal cohort studies in which mothers were recruited during their pregnancy or postpartum period, and the children were assessed at regular intervals. Postpartum psychiatric disorders are generally divided into three categories: postpartum blues, postpartum psychosis and postpartum depression. Postpartum blues is a relatively common emotional disturbance with crying, confusion, mood lability, anxiety and depressed mood. The symptoms appear during the first week postpartum, last for a few hours to a few days and have few negative sequelae. At the other end of the spectrum, postpartum psychosis refers to a severe disorder beginning within four weeks postpartum, with delusions, hallucinations and gross impairment in functioning. Postpartum depression begins in or extends into the postpartum period and core features include dysphoric mood, fatigue, anorexia, sleep disturbances, anxiety, excessive guilt and suicidal thoughts [5]. The diagnosis requires that symptoms be present for at least one month and result in some impairment in the woman’s functioning [6]. Women who have experienced postpartum depression have a 50% to 62% risk for future depressions [7]. Other risk factors for postpartum depression include a history of mood disorders, depression symptoms during the pregnancy and a family history of psychiatric disorders [4]. Stress factors, such as negative life events, poor marital relationships, having a special needs infant or medically ‘fragile’ infant, lack of social support, drug abuse, and personal and family psychopathology, have been associated with postpartum depression in some studies, but other studies have found no association [6]. Postpartum depression tends to be milder than episodes of depression that occur at other times, with lower levels of anxiety, agitation, insomnia and somatic symptoms [8]. However, the duration seems to be the same in postpartum and nonpostpartum depression, and lasts several months [6]. The consequences on the child of maternal postpartum depression are not restricted to infancy, but can extend into toddlerhood, preschool age and even school age. Maternal depression that occurs later influences the development of the school-age child and the adolescent. Table 1 summarizes the consequences of maternal depression from prenatal issues to adolescence. Consequences of maternal depression Consequences of maternal depression The associations between maternal depression, maternal behaviour and child outcomes are complex, and not all studies have found a relationship between maternal depression and indicators of poor parenting. Variations in the type, severity, chronicity and timing of maternal depression [9], heterogeneity in sampling (community versus high-risk multiproblem samples), and potentiating risk factors, such as family adversity, low social support and financial stress [10], all contribute to differences in outcomes in children. On the other hand, stress factors can be responsible for adverse child outcomes in the absence of maternal depression. On a daily basis, infants repeatedly participate in interactive routines with their mothers. Maternal depression compromises the dyad’s capacity to mutually regulate the interaction, through two interactive patterns, intrusiveness or withdrawal. Intrusive mothers display a hostile affect, and disrupt the infant’s activity. The infants experience anger, turn away from the mother to limit her
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“Nonsystematic reviews have indicated that the risks to children of untreated depressed mothers (compared to mothers without PPD) include problems such as poor cognitive functioning, behavioral inhibition, emotional maladjustment, violent behavior, externalizing disorders, and psychiatric and medical disorders in adolescence.5,10–17”
From Consequences of maternal postpartum depression: A systematic review of maternal and infant outcomes (2019) · cites this paper as [17]
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“Untreated PPD seems to have negative consequences for both infants and mothers.”
From Consequences of maternal postpartum depression: A systematic review of maternal and infant outcomes (2019) · cites this paper as [17]
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Winter, C., Acker, F. V., Bonduelle, M., Desmyttere, S., & Nekkebroeck, J. (2015) · Human Reproduction · doi:10.1093/humrep/dev036 · Cited by 22
Effects of maternal depression in the Still-Face Paradigm: A meta-analysis
Graham, K. A., Blissett, J., Antoniou, E. E., Zeegers, M. P., & McCleery, J. P. (2018) · Infant Behavior and Development · doi:10.1016/j.infbeh.2017.12.001 · Cited by 26
“Furthermore, variations in severity, duration and timing of maternal depression have been associated with behavioural differences in children of depressed mothers (Bernard-Bonnin, 2004).”
BackgroundDoes infant negative emotionality moderate the effect of maternal depression on motor development?
Sacchi, C., Carli, P. D., Vieno, A., Piallini, G., Zoia, S., & Simonelli, A. (2018) · Early Human Development · doi:10.1016/j.earlhumdev.2018.03.006 · Cited by 23
“Therefore, maternal depression affects children's development through poor parenting and maladaptive/dysfunctional interactions, with consequences on socioemotional development and neurocognitive functioning extending to school age [14,15] and even to preadolescence [16,17].”
BackgroundGoodman, M. L., Gutarra, C., Billingsley, K., Keiser, P. H., & Gitari, S. (2016) · Anxiety Stress & Coping · doi:10.1080/10615806.2016.1271876 · Cited by 21
Weiss, S. J., & Leung, C. Y. (2021) · Infant Mental Health Journal · doi:10.1002/imhj.21924 · Cited by 22
Maternal depression is associated with less dietary diversity among rural Nepali children
Miller, L. C., Neupane, S., Sparling, T. M., Shrestha, M., Joshi, N., Lohani, M., & Thorne‐Lyman, A. (2021) · Maternal and Child Nutrition · doi:10.1111/mcn.13221 · Cited by 23
Psychosocial well-being in postpartum women with congenital heart disease
Freiberger, A., Beckmann, J., Freilinger, S., Kaemmerer, H. M., Huber, M., Nagdyman, N., Ewert, P., Pieper, L., Deppe, C., Kuschel, B., et al. (2022) · Cardiovascular Diagnosis and Therapy · doi:10.21037/cdt-22-213 · Cited by 25
Soriano, L. D. H., Thurman, A. J., Harvey, D. J., Brown, W. T., & Abbeduto, L. (2018) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-018-9240-2 · Cited by 20
Antenatal determinants of early childhood talking delay and behavioural difficulties
D’Souza, S., Crawford, C. N., Buckley, J., Underwood, L., Peterson, E. R., Bird, A. L., Morton, S., & Waldie, K. E. (2019) · Infant Behavior and Development · doi:10.1016/j.infbeh.2019.101388 · Cited by 23
Chorbadjian, T. N., Deavenport‐Saman, A., Higgins, C., Chao, S. M., Yang, J. H., Koolwijk, I., & Vanderbilt, D. L. (2020) · Maternal and Child Health Journal · doi:10.1007/s10995-020-02990-8 · Cited by 20
Animal models of postpartum depression revisited
Mir, F. R., Pollano, A., & Rivarola, M. A. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105590 · Cited by 21
Housing hardship and maternal mental health among renter households with young children
Marçal, K. E. (2023) · Psychiatry Research · doi:10.1016/j.psychres.2023.115677 · Cited by 20
Elias, C. V., Power, T. G., Beck, A. E., Goodell, L. S., Johnson, S. L., Παπαϊωάννου, Μ. Α., & Hughes, S. O. (2016) · Childhood Obesity · doi:10.1089/chi.2016.0125 · Cited by 19
Nguyen, N. T., & Pengpid, S. (2025) · Frontiers in Global Women's Health · doi:10.3389/fgwh.2025.1497740 · Cited by 24
Saraswat, N., Wal, P., Pal, R. S., Wal, A., Pal, Y., & Roohi, T. F. (2021) · The Open Biology Journal · doi:10.2174/1874196702109010017 · Cited by 17
Jantarabenjakul, W., Chonchaiya, W., Puthanakit, T., Theerawit, T., Payapanon, J., Sophonphan, J., Veeravigom, M., Jahanshad, N., Thompson, P. M., Ananworanich, J., et al. (2019) · Journal of the International AIDS Society · doi:10.1002/jia2.25278 · Cited by 17
Al‐Beltagi, M., Saeed, N. K., Bediwy, A. S., & Elbeltagi, R. M. (2025) · World Journal of Clinical Pediatrics · doi:10.5409/wjcp.v14.i2.103323 · Cited by 27
The diagnosis and management of extrauterine and uterine ectopic pregnancy
Farren, J. A., Wattar, B. H. A., & Jurkovic, D. (2025) · Human Reproduction Update · doi:10.1093/humupd/dmaf024 · Cited by 16
“Bonding with existing or future children may also be impacted; studies have linked maternal depression to poorer long-term socioemotional and cognitive development of children (Bernard-Bonnin, 2004; Bicking Kinsey et al. , 2015).”
Wearing a happy mask: mother’s expressions of suicidality with postpartum depression
Praetorius, R., Maxwell, D., & Alam, K. (2020) · Social Work in Mental Health · doi:10.1080/15332985.2020.1769003 · Cited by 17
Ramadan, M., Rukh-E-Qamar, H., Yang, S., & Vang, Z. M. (2023) · PLoS ONE · doi:10.1371/journal.pone.0287617 · Cited by 17
“Poor maternal mental health has been associated with adverse infant and child development [102].”
BackgroundSha, Q., Galvis, M. L. E., Madaj, Z., Keaton, S. A., Smart, L., Edgerly, Y. M., Anis, E., Leach, R., Osborne, L. M., Achtyes, E. D., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.03.042 · Cited by 18
“Maternal depression, both before and after birth, can also adversely affect children in the long-term, increasing their risk for behavioral disorders and depression through adulthood (Canadian Paediatric Society, 2004; Tir-umalaraju et al., 2020).”
Perinatal Mental Health Support and Early Childhood Home Visitation During COVID-19
Traube, D. E., Molina, A. P., YingWangKay, S., & Kemner, A. L. (2021) · Prevention Science · doi:10.1007/s11121-021-01313-9 · Cited by 16
“…affect disruption, which has been associated with impaired infant development, insecure attachment (Hayes et al., 2013), soothing difficulties (Bernard-Bonnin, 2004), negative emotionality (Teti et al., 1995), self-regulatory disturbances (Khoury et al., 2016), poorer social-competence…”
BackgroundShedding light on maternal mental health in LMICs: a cornerstone of maternal and child health care
Handa, A., Gaidhane, A. M., & Choudhari, S. G. (2024) · Discover Mental Health · doi:10.1007/s44192-024-00111-3 · Cited by 18
Maternal postpartum depressive symptoms and infant externalizing and internalizing behaviors
Vafai, Y., Steinberg, J. R., & Shenassa, E. D. (2016) · Infant Behavior and Development · doi:10.1016/j.infbeh.2015.12.002 · Cited by 15
Levetiracetam in lactation: How much is excreted into human breast milk?
Dinavitser, N., Kohn, E., Berlin, M., Brandriss, N., Bar‐Chaim, A., Keidar, R., Livne, A., Stepensky, D., Berkovitch, M., & Sheinberg, R. (2021) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.14940 · Cited by 15
“It is therefore important to encourage women with epilepsy to breastfeed their infants, while carefully monitoring the mother and the infant, analyzing infant drug exposure via breastmilk, the safety of the specific anti-epileptic drug/s in the infants, and balancing the risks of anti-epilectic therapy in the mother a…”
Background
Metadata
- Authors
- Bernard-Bonnin, A.-C., Canadian Paediatric Society, & Mental Health and Developmental Disabilities Committee
- Venue
- Paediatrics & Child Health
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-10-01
- Volume
- 9
- Issue
- 8
- Pages
- 575-583
- ISSN
- 1205-7088 (ISSN-L)
- 1918-1485
- PMC
- PMC2724169
- OpenAlex
- W2245240757
- Cited by
- 312
- References
- 105
- Citations by year
- 2026: 19 · 2025: 35 · 2024: 39 · 2023: 28 · 2022: 34 · 2021: 39 · 2020: 19 · 2019: 10 · 2018: 25 · 2017: 16 · 2016: 7 · 2015: 12 · 2014: 6 · 2013: 5 · 2012: 2
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Paediatrics & Child Health (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Maternal and Neonatal Healthcare
- Keywords
- maternal depression, postpartum depression, child development, social-emotional development, cognitive development, postpartum psychosis, postpartum blues, maternal depression treatment, antidepressant use in pregnancy, infant development, depression screening, maternal mental health, risk factors for depression, antenatal depression, postpartum depression screening, postpartum depression treatment, postpartum depression recurrence
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