The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Prediction of proprotein convertase cleavage sites
Abstract
Many secretory proteins and peptides are synthesized as inactive precursors that in addition to signal peptide cleavage undergo post-translational processing to become biologically active polypeptides. Precursors are usually cleaved at sites composed of single or paired basic amino acid residues by members of the subtilisin/kexin-like proprotein convertase (PC) family. In mammals, seven members have been identified, with furin being the one first discovered and best characterized. Recently, the involvement of furin in diseases ranging from Alzheimer's disease and cancer to anthrax and Ebola fever has created additional focus on proprotein processing. We have developed a method for prediction of cleavage sites for PCs based on artificial neural networks. Two different types of neural networks have been constructed: a furin-specific network based on experimental results derived from the literature, and a general PC-specific network trained on data from the Swiss-Prot protein database. The method predicts cleavage sites in independent sequences with a sensitivity of 95% for the furin neural network and 62% for the general PC network. The ProP method is made publicly available at http://www.cbs.dtu.dk/services/ProP.
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Citations
Cites
Comparison of the predicted and observed secondary structure of T4 phage lysozyme
Matthews, B. W. (1975) · Biochimica et Biophysica Acta (BBA) - Protein Structure · doi:10.1016/0005-2795(75)90109-9 · Cited by 5,399 · cited 1×
“A correlation coef®cient (Matthews, 1975) was calculated from the numbers of correctly and incorrectly predicted positive and negative sequence windows generated with the selected threshold value.”
MethodIntramolecular chaperones: polypeptide extensions that modulate protein folding
Shinde, U., & Inouye, M. (2000) · Seminars in Cell & Developmental Biology · doi:10.1006/scdb.1999.0349 · Cited by 141 · cited 1×
“…correct folding of the newly synthesized proteins, while other prodomains are only indirectly involved in folding and have other functions such as transport and localization, oligomerization, regulation of activity (Shinde and Inouye, 2000) and quality control of folding (Bauskin et al., 2000).”
Background
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Improved Prediction of Signal Peptides: SignalP 3.0
Dyrløv Bendtsen, J., Nielsen, H., von Heijne, G., & Brunak, S. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.05.028 · Cited by 6,350
Self-citationFurin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis
Silvestri, L., Pagani, A., & Camaschella, C. (2008) · Blood · doi:10.1182/blood-2007-07-100677 · Cited by 311
Suppression of Insulin Production and Secretion by a Decretin Hormone
Alfa, R. W., Park, S., Skelly, K.-R., Poffenberger, G., Jain, N., Gu, X., Kockel, L., Wang, J., Liu, Y., Powers, A. C., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.01.006 · Cited by 150
Global Diversification and Distribution of Coronaviruses With Furin Cleavage Sites
Liu, X., Wu, Q., & Zhang, Z. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.649314 · Cited by 32
Zehr, J. D., Pond, S. L. K., Martin, D. P., Ceres, K., Whittaker, G. R., Millet, J. K., Goodman, L. B., & Stanhope, M. J. (2022) · Viruses · doi:10.3390/v14050853 · Cited by 23
FURIN regulates cytotoxic T-lymphocyte effector function and memory cell transition in mice
Ojanen, M. J. T., Caro, F. M., Aittomäki, S., Ploquin, M. J., Ortutay, Z., Pekkarinen, M., Kesseli, J., Vähätupa, M., Määttä, J., Nykter, M., et al. (2023) · European Journal of Immunology · doi:10.1002/eji.202250246 · Cited by 10
Mining the UniProtKB /Swiss‐Prot database for antimicrobial peptides
Li, C., Sutherland, D., Salehi, A., Richter, A., Lin, D., Aninta, S. I., Ebrahimikondori, H., Yanai, A., Coombe, L., Warren, R. L., et al. (2025) · Protein Science · doi:10.1002/pro.70083 · Cited by 9
Metadata
- Authors
- Duckert, P., Brunak, S., & Blom, N.
- Venue
- Protein Engineering, Design and Selection
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-01
- Volume
- 17
- Issue
- 1
- Pages
- 107-112
- ISSN
- 0269-2139 (ISSN-L)
- 1741-0134
- 1741-0126
- OpenAlex
- W2015936607
- Cited by
- 583
- References
- 2
- FWCI
- 5.47
- Type
- journal article
- Language
- en
- Open access
- closed
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