High in vivo expression of interleukin‐17 receptor in synovial endothelial cells and chondrocytes from arthritis patients
Abstract
OBJECTIVE: To evaluate the presence of interleukin-17 (IL-17) and the expression of IL-17 receptor (IL-17R) in joint tissues from subjects with different arthritides. METHODS: Immunohistochemistry was used on frozen synovial and cartilage biopsies to identify cells expressing IL-17 and IL-17R. RESULTS: IL-17 staining was present only in synovial biopsies of rheumatoid arthritis (RA) (seven out of nine cases). IL-17R was expressed by all synovial biopsies evaluated except for three cases of post-traumatic arthritis (PTA). Vascular endothelial cells mainly expressed IL-17R. The percentage of IL-17R(+) vessels was the highest in RA synovium and the lowest in PTA. Chondrocytes from all types of arthritides were negative for IL-17 staining, but expressed IL-17R; the highest percentage of positive chondrocytes was found in seronegative spondylarthritis and the lowest in RA. CONCLUSIONS: IL-17-positive cells are found exclusively in RA. On the other hand, synovial endothelial cells and chondrocytes expressing IL-17R are found in the majority of patients with different types of arthritis. This finding suggests a role for a second ligand for IL-17R, which could be either a different cytokine or a different isoform of IL-17.
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Transfer of in vitro differentiated pathogenic Th17 cells expressing a MOG35-55-specific transgenic TCR is sufficient to induce severe disease in recipient mice.
“the transfer of in vitro differentiated pathogenic Th17 cells expressing a transgenic TCR specific for the MOG35–55 peptide (2D2 cells [114]) is sufficient to induce severe disease in recipient mice”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [114]
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- Authors
- Honorati, M. C., Meliconi, R., Pulsatelli, L., Canè, S., Frizziero, L., & Facchini, A.
- Venue
- Rheumatology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-05
- Volume
- 40
- Issue
- 5
- Pages
- 522-527
- ISSN
- 1462-0324 (ISSN-L)
- 1462-0332
- OpenAlex
- W2149652100
- Cited by
- 99
- References
- 37
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 5 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 5 · 2016: 7 · 2015: 4 · 2014: 3 · 2013: 6 · 2012: 4
- FWCI
- 2.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Lara D. Veeken (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Keywords
- IL-17, interleukin-17 receptor, rheumatoid arthritis, chondrocytes, post-traumatic arthritis, seronegative spondyloarthropathy, synovium, cartilage
- MeSH terms
- Adolescent, Adult, Arthritis, Cell Count, Endothelium, Vascular, Female, Humans, Male, Middle Aged, Synovial Membrane, Antigens, CD, Fluorescent Antibody Technique, Indirect, Chondrocytes, Receptors, Interleukin-7
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