Targeting interleukin-17 in chronic inflammatory disease: A clinical perspective

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

Mosmann, T. R., Cherwinski, H. M., Bond, M. W., Giedlin, M. A., & Coffman, R. L. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.7.2348 · Cited by 7,438 · see citing works

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145 · see citing works

IL-17 and th17 cells

Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873 · see citing works

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554 · see citing works

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y.-H., Wang, Y., Hood, L., Zhu, Z., Tian, Q., et al. (2005) · Nature Immunology · doi:10.1038/ni1261 · Cited by 4,265 · see citing works

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A., & Cua, D. J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041257 · Cited by 4,099 · see citing works

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605 · see citing works

A Genome-Wide Association Study Identifies <i>IL23R</i> as an Inflammatory Bowel Disease Gene

Duerr, R. H., Taylor, K. D., Brant, S. R., Rioux, J. D., Silverberg, M. S., Daly, M. J., Steinhart, A. H., Abraham, C., Regueiro, M., Griffiths, A., et al. (2006) · Science · doi:10.1126/science.1135245 · Cited by 3,039 · see citing works

Rheumatoid arthritis

Scott, D. L., Wolfe, F., & Huizinga, T. W. J. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60826-4 · Cited by 3,019 · see citing works

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

Cua, D. J., Sherlock, J., Chen, Y., Murphy, C. A., Joyce, B., Seymour, B., Lucian, L., To, W., Kwan, S., Churakova, T., et al. (2003) · Nature · doi:10.1038/nature01355 · Cited by 2,906 · see citing works

Inflammatory bowel disease

Abraham, C., & Cho, J. H. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804647 · Cited by 2,712 · see citing works

Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis

van der Fits, L., Mourits, S., Voerman, J. S. A., Kant, M., Boon, L., Laman, J. D., Cornelissen, F., Mus, A.-M. C., Florencia, E. F., Prens, E. P., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802999 · Cited by 2,202 · see citing works

Secukinumab in plaque psoriasis—results of two phase 3 trials

Langley, R. G., Elewski, B. E., Lebwohl, M., Reich, K., Griffiths, C. E. M., Papp, K., Puig, L., Nakagawa, H., Spelman, L., Sigurgeirsson, B., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1314258 · Cited by 1,997 · see citing works

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

Zheng, Y., Valdez, P. A., Danilenko, D. M., Hu, Y., Susan, M. L., Gong, Q., Abbas, A. R., Modrusan, Z. D., Ghilardi, N., de Sauvage, F. J., et al. (2008) · Nature Medicine · doi:10.1038/nm1720 · Cited by 1,910 · see citing works

Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)

Leonardi, C. L., Kimball, A. B., Papp, K. A., Yeilding, N. M., Guzzo, C. A., Wang, Y., Li, S., Dooley, L. T., & Gordon, K. B. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60725-4 · Cited by 1,870 · see citing works

Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17

Aggarwal, S., Ghilardi, N., Xie, M.-H., de Sauvage, F. J., & Gurney, A. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207577200 · Cited by 1,848 · see citing works

Increased expression of interleukin 17 in inflammatory bowel disease

Fujino, S., Andoh, A., Bamba, S., Ogawa, A., Hata, K., Araki, Y., Bamba, T., & Fujiyama, Y. (2003) · Gut · doi:10.1136/gut.52.1.65 · Cited by 1,713 · see citing works

IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis

Kotake, S., Udagawa, N., Takahashi, N., Matsuzaki, K., Itoh, K., Ishiyama, S., Saito, S., Inoue, K., Kamatani, N., Gillespie, M. T., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5703 · Cited by 1,696 · see citing works

Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.

Keffer, J., Probert, L., Cazlaris, H., Georgopoulos, S., Kaslaris, E., Kioussis, D., & Kollias, G. (1991) · EMBO Journal · doi:10.1002/j.1460-2075.1991.tb04978.x · Cited by 1,675 · see citing works

Innate IL-17-producing cells: the sentinels of the immune system

Cua, D. J., & Tato, C. M. (2010) · Nature reviews. Immunology · doi:10.1038/nri2800 · Cited by 1,578 · see citing works

Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells

Wu, H.-J., Ivanov, I. I., Darce, J., Hattori, K., Shima, T., Umesaki, Y., Littman, D. R., Benoist, C., & Mathis, D. (2010) · Immunity · doi:10.1016/j.immuni.2010.06.001 · Cited by 1,577 · see citing works

Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction

Sato, K., Suematsu, A., Okamoto, K., Yamaguchi, A., Morishita, Y., Kadono, Y., Tanaka, S., Kodama, T., Akira, S., Iwakura, Y., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061775 · Cited by 1,554 · see citing works

Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity

Sutton, C. E., Lalor, S. J., Sweeney, C. M., Brereton, C. F., Lavelle, E. C., & Mills, K. H. G. (2009) · Immunity · doi:10.1016/j.immuni.2009.08.001 · Cited by 1,553 · see citing works

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn’s disease: unexpected results of a randomised, double-blind placebo-controlled trial

Hueber, W., Sands, B. E., Lewitzky, S., Vandemeulebroecke, M., Reinisch, W., Higgins, P. D. R., Wehkamp, J., Feagan, B. G., Yao, M. D., Karczewski, M., et al. (2012) · Gut · doi:10.1136/gutjnl-2011-301668 · Cited by 1,547 · see citing works

IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis

Komiyama, Y., Nakae, S., Matsuki, T., Nambu, A., Ishigame, H., Kakuta, S., Sudo, K., & Iwakura, Y. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.1.566 · Cited by 1,536 · see citing works

IL-23 is essential for T cell–mediated colitis and promotes inflammation via IL-17 and IL-6

Yen, D., Cheung, J., Scheerens, H., Poulet, F. M., McClanahan, T. K., McKenzie, B. S., Kleinschek, M. A., Owyang, A. M., Mattson, J. D., Blumenschein, W. M., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci21404 · Cited by 1,532 · see citing works

T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines

Fossiez, F., Djossou, O., Chomarat, P., Flores-Romo, L., Ait-Yahia, S., Maat, C., Pin, J. J., Garrone, P., Garcia, E., Saeland, S., et al. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.6.2593 · Cited by 1,526 · see citing works

TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology

McGeachy, M. J., Bak-Jensen, K. S., Chen, Y., Tato, C. M., Blumenschein, W., McClanahan, T., & Cua, D. J. (2007) · Nature Immunology · doi:10.1038/ni1539 · Cited by 1,520 · see citing works

The IL-17 Family of Cytokines in Health and Disease

McGeachy, M. J., Cua, D. J., & Gaffen, S. L. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.021 · Cited by 1,443 · see citing works

Psoriatic Arthritis

Ritchlin, C. T., Colbert, R. A., & Gladman, D. D. (2017) · New England Journal of Medicine · doi:10.1056/nejmra1505557 · Cited by 1,403 · see citing works

Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)

Papp, K. A., Langley, R. G. B., Lebwohl, M., Krueger, G. G., Szapary, P. O., Yeilding, N. M., Guzzo, C. A., Hsu, M.-C., Wang, Y., Li, S., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60726-6 · Cited by 1,358 · see citing works

Suppression of Immune Induction of Collagen-Induced Arthritis in IL-17-Deficient Mice

Nakae, S., Nambu, A., Sudo, K., & Iwakura, Y. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.11.6173 · Cited by 1,272 · see citing works

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

Codarri, L., Gyülvészi, G., Tosevski, V., Hesske, L., Fontana, A., Magnenat, L., Suter, T., & Becher, B. (2011) · Nature Immunology · doi:10.1038/ni.2027 · Cited by 1,191 · cited 7× · see citing works

Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis

Tzartos, J. S., Friese, M. A., Craner, M. J., Palace, J. A., Newcombe, J., Esiri, M. M., & Fugger, L. H. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070690 · Cited by 1,180 · see citing works

T cell subsets and their signature cytokines in autoimmune and inflammatory diseases

Raphael, I., Nalawade, S. A., Eagar, T. N., & Forsthuber, T. G. (2014) · Cytokine · doi:10.1016/j.cyto.2014.09.011 · Cited by 1,177 · see citing works

Induction and molecular signature of pathogenic TH17 cells

Lee, Y., Awasthi, A., Yosef, N., Quintana, F. J., Xiao, S., Peters, A., Wu, C., Kleinewietfeld, M., Kunder, S., Hafler, D. A., et al. (2012) · Nature Immunology · doi:10.1038/ni.2416 · Cited by 1,174 · see citing works

Etanercept as Monotherapy in Patients with Psoriasis

Leonardi, C. L., POWERS, J. L., Matheson, R. T., Goffe, B. S., Zitnik, R. J., Wang, A., & Gottlieb, A. B. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030409 · Cited by 1,173 · see citing works

Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis

Komatsu, N., Okamoto, K., Sawa, S., Nakashima, T., Oh-hora, M., Kodama, T., Tanaka, S., Bluestone, J. A., & Takayanagi, H. (2014) · Nature Medicine · doi:10.1038/nm.3432 · Cited by 1,153 · see citing works

Plasmacytoid predendritic cells initiate psoriasis through interferon-α production

Nestle, F. O., Conrad, C., Tun-Kyi, A., Homey, B., Gombert, M., Boyman, O., Burg, G., Liu, Y.-J., & Gilliet, M. F. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050500 · Cited by 1,126 · see citing works

The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

El-Behi, M., Ciric, B., Dai, H., Yan, Y., Cullimore, M., Safavi, F., Zhang, G.-X., Dittel, B. N., & Rostami, A. (2011) · Nature Immunology · doi:10.1038/ni.2031 · Cited by 1,071 · see citing works

Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology

Buonocore, S. M., Ahern, P. P., Uhlig, H. H., Ivanov, I. I., Littman, D. R., Maloy, K. J., & Powrie, F. M. (2010) · Nature · doi:10.1038/nature08949 · Cited by 1,066 · see citing works

Pivotal Role of Dermal IL-17-Producing γδ T Cells in Skin Inflammation

Cai, Y., Shen, X., Ding, C., Qi, C., Li, K., Li, X., Jala, V. R., Zhang, H., Wang, T., Zheng, J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.08.001 · Cited by 1,031 · see citing works

Secukinumab, an Interleukin-17A Inhibitor, in Ankylosing Spondylitis

Baeten, D., Sieper, J., Braun, J., Baraliakos, X., Dougados, M., Emery, P., Deodhar, A. A., Porter, B. O., Martin, R., Andersson, M., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1505066 · Cited by 1,030 · see citing works

Immunisation against heterologous type II collagen induces arthritis in mice

COURTENAY, J. S., Dallman, M. J., Dayan, A. D., Martin, A. J., & Mosedale, B. (1980) · Nature · doi:10.1038/283666a0 · Cited by 1,025 · see citing works

Human IL-17: a novel cytokine derived from T cells

Yao, Z., Painter, S. L., Fanslow, W. C., Ulrich, D., Macduff, B. M., Spriggs, M. K., & Armitage, R. J. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.12.5483 · Cited by 1,021 · see citing works

Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor

Yao, Z., Fanslow, W. C., Seldin, M. F., Rousseau, A.-M., Painter, S. L., Comeau, M. R., Cohen, J. I., & Spriggs, M. K. (1995) · Immunity · doi:10.1016/1074-7613(95)90070-5 · Cited by 995 · see citing works

IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages.

Jovanović, D., Battista, J. A. D., Pelletier, J., Jolicoeur, F. C., He, Y., Zhang, M., Mineau, F., & Martel‐Pelletier, J. (1998) · PubMed · Cited by 973 · see citing works

Mast Cells and Neutrophils Release IL-17 through Extracellular Trap Formation in Psoriasis

Lin, A. M., Rubin, C. J., Khandpur, R., Wang, J. Y., Riblett, M., Yalavarthi, S., Villanueva, E. C., Shah, P., Kaplan, M. J., & Bruce, A. T. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100123 · Cited by 906 · see citing works

Efficacy and safety of guselkumab, an anti-interleukin-23 monoclonal antibody, compared with adalimumab for the continuous treatment of patients with moderate to severe psoriasis: Results from the phase III, double-blinded, placebo- and active comparator–controlled VOYAGE 1 trial

Blauvelt, A., Papp, K. A., Griffiths, C. E. M., Randazzo, B. P., Wasfi, Y. S., Shen, Y., Li, S., & Kimball, A. B. (2017) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2016.11.041 · Cited by 899 · see citing works

Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease

Onishi, R. M., & Gaffen, S. L. (2010) · Immunology · doi:10.1111/j.1365-2567.2009.03240.x · Cited by 894 · see citing works

IL-17 Stimulates the Production and Expression of Proinflammatory Cytokines, IL-β and TNF-α, by Human Macrophages

Jovanović, D., Battista, J. A. D., Martel‐Pelletier, J., Jolicoeur, F. C., He, Y., Zhang, M., Mineau, F., & Pelletier, J. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.7.3513 · Cited by 867 · see citing works

Secukinumab, a human anti-interleukin-17A monoclonal antibody, in patients with psoriatic arthritis (FUTURE 2): a randomised, double-blind, placebo-controlled, phase 3 trial

McInnes, I. B., Mease, P. J., Kirkham, B. W., Kavanaugh, A., Ritchlin, C. T., Rahman, P., van der Heijde, D. M. F. M., Landewé, R., Conaghan, P. G., Gottlieb, A. B., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)61134-5 · Cited by 859 · see citing works

Phase 3 Trials of Ixekizumab in Moderate-to-Severe Plaque Psoriasis

Gordon, K. B., Blauvelt, A., Papp, K. A., Langley, R. G. B., Luger, T. A., Ohtsuki, M., Reich, K., Amato, D. A., Ball, S. G., Braun, D. K., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1512711 · Cited by 851 · see citing works

Comparison of ixekizumab with etanercept or placebo in moderate-to-severe psoriasis (UNCOVER-2 and UNCOVER-3): results from two phase 3 randomised trials

Griffiths, C. E. M., Reich, K., Lebwohl, M., van de Kerkhof, P., Paul, C., Menter, A., Cameron, G. S., Erickson, J., Zhang, L., Secrest, R. J., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60125-8 · Cited by 834 · see citing works

Phase 3 Studies Comparing Brodalumab with Ustekinumab in Psoriasis

Lebwohl, M., Strober, B. E., Menter, A., Gordon, K. B., Węgłowska, J., Puig, L., Papp, K. A., Spelman, L. J., Toth, D. P., Kerdel, F. A., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1503824 · Cited by 830 · see citing works

Interleukin-23 drives innate and T cell–mediated intestinal inflammation

Hue, S., Ahern, P., Buonocore, S., Kullberg, M. C., Cua, D. J., McKenzie, B. S., Powrie, F., & Maloy, K. J. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061099 · Cited by 823 · see citing works

Commensal–dendritic-cell interaction specifies a unique protective skin immune signature

Naik, S., Bouladoux, N., Linehan, J. L., Han, S.-J., Harrison, O. J., Wilhelm, C., Conlan, S., Himmelfarb, S., Byrd, A. L., Deming, C., et al. (2015) · Nature · doi:10.1038/nature14052 · Cited by 820 · see citing works

Efficacy and safety of ustekinumab in patients with active psoriatic arthritis: 1 year results of the phase 3, multicentre, double-blind, placebo-controlled PSUMMIT 1 trial

McInnes, I. B., Kavanaugh, A., Gottlieb, A. B., Puig, L., Rahman, P., Ritchlin, C. T., Brodmerkel, C. M., Li, S., Wang, Y., Mendelsohn, A. M., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60594-2 · Cited by 799 · see citing works

IL-17 Signaling: The Yin and the Yang

Amatya, N., Garg, A. V., & Gaffen, S. L. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.01.006 · Cited by 785 · see citing works

CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene

Rouvier, É., Luciani, M., Mattéi, M., Denizot, F., & Golstein, P. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.12.5445 · Cited by 776 · see citing works

Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability

Lee, J. S., Tato, C. M., Joyce-Shaikh, B., Gulen, M. F., Cayatte, C., Chen, Y., Blumenschein, W. M., Judo, M., Ayanoglu, G., McClanahan, T. K., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.09.003 · Cited by 760 · see citing works

A protective function for interleukin 17A in T cell–mediated intestinal inflammation

O'Connor Jr, W., Kamanaka, M., Booth, C. J., Town, T., Nakae, S., Iwakura, Y., Kolls, J. K., & Flavell, R. A. (2009) · Nature Immunology · doi:10.1038/ni.1736 · Cited by 756 · see citing works

Treatment of multiple sclerosis with gamma interferon

PANITCH, H. S., Hirsch, R. L., Schindler, J. D., & Johnson, K. P. (1987) · Neurology · doi:10.1212/wnl.37.7.1097 · Cited by 752 · see citing works

Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis

Matusevičius, D., Kivisäkk, P., He, B., Kostulas, N., Özenci, V., Fredrikson, S., & Link, H. (1999) · Multiple Sclerosis Journal · doi:10.1177/135245859900500206 · Cited by 751 · see citing works

Secukinumab Inhibition of Interleukin-17A in Patients with Psoriatic Arthritis

Mease, P. J., McInnes, I. B., Kirkham, B. W., Kavanaugh, A., Rahman, P., van der Heijde, D. M. F. M., Landewé, R., Nash, P. T., Pricop, L., Yuan, J., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1412679 · Cited by 745 · see citing works

Inflammatory memory sensitizes skin epithelial stem cells to tissue damage

Naik, S., Larsen, S. B., Gomez, N. C., Alaverdyan, K., Sendoel, A., Yuan, S., Polak, L., Kulukian, A., Chai, S., & Fuchs, E. (2017) · Nature · doi:10.1038/nature24271 · Cited by 745 · see citing works

Treatment with a neutralizing anti‐murine interleukin‐17 antibody after the onset of collagen‐induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion

Lubberts, E., Koenders, M. I., Oppers‐Walgreen, B., van den Bersselaar, L., Roo, C. J. J. C., Joosten, L. A. B., & van den Berg, W. B. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20001 · Cited by 709 · see citing works

Th17 Cell Differentiation: The Long and Winding Road

McGeachy, M. J., & Cua, D. J. (2008) · Immunity · doi:10.1016/j.immuni.2008.03.001 · Cited by 700 · see citing works

Efficacy and safety of risankizumab in moderate-to-severe plaque psoriasis (UltIMMa-1 and UltIMMa-2): results from two double-blind, randomised, placebo-controlled and ustekinumab-controlled phase 3 trials

Gordon, K. B., Strober, B. E., Lebwohl, M., Augustin, M., Blauvelt, A., Poulin, Y. P., Papp, K. A., Sofen, H. L., Puig, L., Foley, P. A., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31713-6 · Cited by 678 · see citing works

Randomized, Double-Blind, Placebo-controlled Study of Brodalumab, a Human Anti–IL-17 Receptor Monoclonal Antibody, in Moderate to Severe Asthma

Busse, W. W., Holgate, S. T., Kerwin, E., Chon, Y., Feng, J., Lin, J., & Lin, S. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201212-2318oc · Cited by 667 · see citing works

Control of TH17 cells occurs in the small intestine

Esplugues, E., Huber, S., Gagliani, N., Hauser, A. E., Town, T., Wan, Y. Y., O’Connor, W., Rongvaux, A., van Rooijen, N., Haberman, A. M., et al. (2011) · Nature · doi:10.1038/nature10228 · Cited by 643 · see citing works

Identification of an IL-17–producing NK1.1neg iNKT cell population involved in airway neutrophilia

Michel, M., Keller, A. C., Paget, C., Fujio, M., Trottein, F., Savage, P. B., Wong, C., Schneider, E., Dy, M., & Leite‐de‐Moraes, M. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061551 · Cited by 618 · see citing works

Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins

Zenz, R., Eferl, R., Kenner, L., Florin, L., Hummerich, L., Mehic, D., Scheuch, H., Angel, P. E., Tschachler, E., & Wagner, E. F. (2005) · Nature · doi:10.1038/nature03963 · Cited by 599 · see citing works

IL-17 family: Cytokines, receptors and signaling

Gu, C., Wu, L., & Li, X. (2013) · Cytokine · doi:10.1016/j.cyto.2013.07.022 · Cited by 597 · see citing works

Ixekizumab, an interleukin-17A specific monoclonal antibody, for the treatment of biologic-naive patients with active psoriatic arthritis: results from the 24-week randomised, double-blind, placebo-controlled and active (adalimumab)-controlled period of the phase III trial SPIRIT-P1

Mease, P. J., van der Heijde, D. M. F. M., Ritchlin, C. T., Okada, M., Cuchacovich, R., Shuler, C. L., Lin, C., Braun, D. K., Lee, C. H., & Gladman, D. D. (2016) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2016-209709 · Cited by 582 · see citing works

High Levels of IL-17 in Rheumatoid Arthritis Patients: IL-15 Triggers In Vitro IL-17 Production Via Cyclosporin A-Sensitive Mechanism

Ziolkowska, M., Koc, A., Luszczykiewicz, G., Ksiezopolska-Pietrzak, K., Klimczak, E., Chwalinska-Sadowska, H., & Maslinski, W. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.5.2832 · Cited by 580 · see citing works

Tildrakizumab versus placebo or etanercept for chronic plaque psoriasis (reSURFACE 1 and reSURFACE 2): results from two randomised controlled, phase 3 trials

Reich, K., Papp, K. A., Blauvelt, A., Tyring, S. K., Sinclair, R. D., Thaçi, D., Nograles, K. E., Mehta, A., Cichanowitz, N., Li, Q., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31279-5 · Cited by 570 · see citing works

IL-17, Produced by Lymphocytes and Neutrophils, Is Necessary for Lipopolysaccharide-Induced Airway Neutrophilia: IL-15 as a Possible Trigger

Ferretti, S., Bonneau, O., Dubois, G. R., Jones, C. E., & Trifilieff, A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.4.2106 · Cited by 542 · see citing works

Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells

Ahern, P. P., Schiering, C., Buonocore, S., McGeachy, M. J., Cua, D. J., Maloy, K. J., & Powrie, F. (2010) · Immunity · doi:10.1016/j.immuni.2010.08.010 · Cited by 528 · see citing works

Spontaneous Development of Psoriasis in a New Animal Model Shows an Essential Role for Resident T Cells and Tumor Necrosis Factor-α

Boyman, O., Hefti, H. P., Conrad, C., Nickoloff, B. J., Suter, M., & Nestle, F. O. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031482 · Cited by 521 · see citing works

Rorγt+ innate lymphocytes and γδ T cells initiate psoriasiform plaque formation in mice

Pantelyushin, S., Haak, S., Ingold, B., Kulig, P., Heppner, F. L., Navarini, A. A., & Becher, B. (2012) · Journal of Clinical Investigation · doi:10.1172/jci61862 · Cited by 515 · see citing works

Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice

Ogawa, A., Andoh, A., Araki, Y., Bamba, T., & Fujiyama, Y. (2003) · Clinical Immunology · doi:10.1016/j.clim.2003.09.013 · Cited by 495 · see citing works

IL-17 produced by neutrophils regulates IFN-γ–mediated neutrophil migration in mouse kidney ischemia-reperfusion injury

Li, L., Huang, L., Vergis, A. L., Ye, H., Bajwa, A., Narayan, V., Strieter, R. M., Rosin, D. L., & Okusa, M. D. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38702 · Cited by 485 · see citing works

Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12.

Becher, B., Durell, B., & Noelle, R. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15751 · Cited by 481 · see citing works

Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study

Segal, B. M., Constantinescu, C. S., Raychaudhuri, A., Kim, L., Fidelus-Gort, R., & Kasper, L. H. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70173-x · Cited by 479 · see citing works

T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis

Hirota, K., Hashimoto, M., Yoshitomi, H., Tanaka, S., Nomura, T., Yamaguchi, T., Iwakura, Y., Sakaguchi, N., & Sakaguchi, S. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062259 · Cited by 475 · see citing works

A prospective phase III, randomized, double‐blind, placebo‐controlled study of brodalumab in patients with moderate‐to‐severe plaque psoriasis

Papp, K. A., Reich, K., Paul, C. F., Blauvelt, A., Baran, W., Bolduc, C., Toth, D., Langley, R. G. B., Cather, J. C., Gottlieb, A. B., et al. (2016) · British Journal of Dermatology · doi:10.1111/bjd.14493 · Cited by 471 · see citing works

Psoriasis

Perera, G. K., Meglio, P. D., & Nestle, F. O. (2011) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-011811-132448 · Cited by 464 · see citing works

Claudins regulate the intestinal barrier in response to immune mediators

Kinugasa, T., Sakaguchi, T., Gu, X., & Reinecker, H. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)70351-9 · Cited by 463 · see citing works

Enhancing Effect of IL-17 on IL-1-Induced IL-6 and Leukemia Inhibitory Factor Production by Rheumatoid Arthritis Synoviocytes and Its Regulation by Th2 Cytokines

Chabaud, M., Fossiez, F., Taupin, J., & Miossec, P. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.1.409 · Cited by 457 · see citing works

Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair

Linehan, J. L., Harrison, O. J., Han, S.-J., Byrd, A. L., Vujkovic-Cvijin, I., Villarino, A. V., Sen, S. K., Shaik, J., Smelkinson, M., Tamoutounour, S., et al. (2018) · Cell · doi:10.1016/j.cell.2017.12.033 · Cited by 456 · see citing works

Monoclonal Anti–Interleukin 23 Reverses Active Colitis in a T Cell–Mediated Model in Mice

Elson, C. O., Cong, Y., Weaver, C. T., Schoeb, T. R., McClanahan, T. K., Fick, R. B., & Kastelein, R. A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.104 · Cited by 453 · see citing works

Induction therapy with the selective interleukin-23 inhibitor risankizumab in patients with moderate-to-severe Crohn's disease: a randomised, double-blind, placebo-controlled phase 2 study

Feagan, B. G., Sandborn, W. J., D'Haens, G., Panés, J., Kaser, A., Ferrante, M., Louis, E., Franchimont, D., Dewit, O., Seidler, U., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30570-6 · Cited by 451 · see citing works

Cutting Edge: Roles of Toll-Like Receptor 4 and IL-23 in IL-17 Expression in Response to Klebsiella pneumoniae Infection

Happel, K. I., Zheng, M., Young, E. A., Quinton, L. J., Lockhart, E., Ramsay, A. J., Shellito, J. E., Schurr, J. R., Bagby, G. J., Nelson, S., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.9.4432 · Cited by 448 · see citing works

RORγ-Expressing Th17 Cells Induce Murine Chronic Intestinal Inflammation via Redundant Effects of IL-17A and IL-17F

Leppkes, M., Becker, C., Ivanov, I. I., Hirth, S., Wirtz, S. J., Neufert, C. F., Pouly, S., Murphy, A. J., Valenzuela, D. M., Yancopoulos, G. D., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.10.018 · Cited by 445 · see citing works

Th17 and Th1 T-Cell Responses in Giant Cell Arteritis

Deng, J., Younge, B. R., Olshen, R. A., Goronzy, J. J., & Weyand, C. M. (2010) · Circulation · doi:10.1161/circulationaha.109.872903 · Cited by 435 · see citing works

Rheumatoid arthritis and the mucosal origins hypothesis: protection turns to destruction

Holers, V. M., Demoruelle, M. K., Kuhn, K. A., Buckner, J. H., Robinson, W. H., Okamoto, Y., Norris, J. M., & Deane, K. D. (2018) · Nature Reviews Rheumatology · doi:10.1038/s41584-018-0070-0 · Cited by 425 · see citing works

Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis

Hofstetter, H. H., Ibrahim, S. M., Koczan, D., Kruse, N., Weishaupt, A., Toyka, K. V., & Gold, R. (2005) · Cellular Immunology · doi:10.1016/j.cellimm.2005.11.002 · Cited by 418 · see citing works

Ixekizumab for the treatment of patients with active psoriatic arthritis and an inadequate response to tumour necrosis factor inhibitors: results from the 24-week randomised, double-blind, placebo-controlled period of the SPIRIT-P2 phase 3 trial

Nash, P. T., Kirkham, B. W., Okada, M., Rahman, P., Combe, B., Burmester, G., Adams, D. H., Kerr, L., Lee, C., Shuler, C. L., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31429-0 · Cited by 406 · see citing works

IL-1-Independent Role of IL-17 in Synovial Inflammation and Joint Destruction During Collagen-Induced Arthritis

Lubberts, E., Joosten, L. A. B., Oppers‐Walgreen, B., van den Bersselaar, L., Roo, C. J. J. C., Kolls, J. K., Schwarzenberger, P. O., van de Loo, F. A. J., & van den Berg, W. B. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.2.1004 · Cited by 401 · see citing works

IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice

Haak, S., Croxford, A. L., Kreymborg, K., Heppner, F. L., Pouly, S., Becher, B., & Waisman, A. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35997 · Cited by 398 · see citing works

Brodalumab, an Anti-IL17RA Monoclonal Antibody, in Psoriatic Arthritis

Mease, P. J., Genovese, M. C., Greenwald, M., Ritchlin, C. T., Beaulieu, A. D., Deodhar, A. A., Newmark, R., Feng, J., Erondu, N., & Nirula, A. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1315231 · Cited by 394 · see citing works

Risankizumab, an IL-23 inhibitor, for ankylosing spondylitis: results of a randomised, double-blind, placebo-controlled, proof-of-concept, dose-finding phase 2 study

Baeten, D., Østergaard, M., Wei, J. C.-C., Sieper, J., Järvinen, P., Tam, L.-S., Salvarani, C., Kim, T.-H., Solinger, A., Datsenko, Y., et al. (2018) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2018-213328 · Cited by 390 · see citing works

Interleukin-17-induced Gene Expression in Articular Chondrocytes Is Associated with Activation of Mitogen-activated Protein Kinases and NF-κB

Shalom‐Barak, T., Quach, J., & Lotz, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.42.27467 · Cited by 385 · see citing works

A Randomized, Double-Blind, Placebo-Controlled Phase 2 Study of Brodalumab in Patients With Moderate-to-Severe Crohn’s Disease

Targan, S. R., Feagan, B., Vermeire, S., Panaccione, R., Melmed, G. Y., Landers, C., Li, D., Russell, C., Newmark, R., Zhang, N., et al. (2016) · American Journal of Gastroenterology · doi:10.1038/ajg.2016.298 · Cited by 383 · see citing works

Ixekizumab, an interleukin-17A antagonist in the treatment of ankylosing spondylitis or radiographic axial spondyloarthritis in patients previously untreated with biological disease-modifying anti-rheumatic drugs (COAST-V): 16 week results of a phase 3 randomised, double-blind, active-controlled and placebo-controlled trial

van der Heijde, D. M. F. M., Wei, J. C., Dougados, M., Mease, P. J., Deodhar, A. A., Maksymowych, W. P., den Bosch, F. E. V., Sieper, J., Tomita, T., Landewé, R., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31946-9 · Cited by 372 · see citing works

Interleukin-17 and its expanding biological functions

Xu, S., & Cao, X. (2010) · Cellular and Molecular Immunology · doi:10.1038/cmi.2010.21 · Cited by 358 · see citing works

IL-17 is produced by nickel-specific T lymphocytes and regulates ICAM-1 expression and chemokine production in human keratinocytes: synergistic or antagonist effects with IFN-gamma and TNF-alpha.

Albanesi, C., Cavani, A., & Girolomoni, G. (1999) · PubMed · Cited by 355 · see citing works

Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin

Johansen, C., Usher, P. A., Kjellerup, R. B., Lundsgaard, D., Iversen, L., & Kragballe, K. (2009) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08902.x · Cited by 348 · see citing works

Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12

Becher, B., Durell, B. G., & Noelle, R. J. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215751 · Cited by 347 · see citing works

Differential Roles for Interleukin-23 and Interleukin-17 in Intestinal Immunoregulation

Maxwell, J. R., Zhang, Y., Brown, W. A., Smith, C. L., Byrne, F. R., Fiorino, M., Stevens, E., Bigler, J., Davis, J. A., Rottman, J. B., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.08.019 · Cited by 342 · see citing works

Efficacy and safety of guselkumab in patients with psoriasis who have an inadequate response to ustekinumab: results of the randomized, double‐blind, phase III NAVIGATE trial

Langley, R. G. B., Tsai, T., Flavin, S. K., Song, M., Randazzo, B. P., Wasfi, Y. S., Jiang, J., Li, S., & Puig, L. (2017) · British Journal of Dermatology · doi:10.1111/bjd.15750 · Cited by 341 · see citing works

Interleukin 17 Family Cytokines: Signaling Mechanisms, Biological Activities, and Therapeutic ImplicationsPreprint

Monin, L., & Gaffen, S. L. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028522 · Cited by 338 · see citing works

Synovial membrane cytokine expression is predictive of joint damage progression in rheumatoid arthritis: A two‐year prospective study (the DAMAGE study cohort)

Kirkham, B. W., Lassere, M. N., Edmonds, J. P., Juhasz, K. M., Bird, P. A., Lee, C. S., Shnier, R., & Portek, I. J. (2006) · Arthritis &amp; Rheumatism · doi:10.1002/art.21749 · Cited by 336 · see citing works

IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis

Chabaud, M., Lubberts, E., Joosten, L., van den Berg, W., & Miossec, P. (2001) · Arthritis Research & Therapy · doi:10.1186/ar294 · Cited by 333 · see citing works

T-bet is essential for encephalitogenicity of both Th1 and Th17 cells

Yang, Y.-H., Weiner, J., Liu, Y., Smith, A., Huss, D., Winger, R., Peng, H.-Y., Cravens, P., Racke, M., & Lovett-Racke, A. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20082584 · Cited by 332 · see citing works

The Incidence and Risk Factors for Psoriatic Arthritis in Patients With Psoriasis: A Prospective Cohort Study

Eder, L., Haddad, A., Rosen, C. F., Lee, K., Chandran, V., Cook, R. J., & Gladman, D. D. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39494 · Cited by 327 · see citing works

Intestinal Interleukin-17 Receptor Signaling Mediates Reciprocal Control of the Gut Microbiota and Autoimmune Inflammation

Kumar, P., Monin, L., Castillo, P., Elsegeiny, W., Horne, W., Eddens, T., Vikram, A., Good, M., Schoenborn, A. A., Bibby, K., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.007 · Cited by 326 · see citing works

Magnetic resonance imaging-determined synovial membrane volume as a marker of disease activity and a predictor of progressive joint destruction in the wrists of patients with rheumatoid arthritis

́stergaard, M., Hansen, M. S., Stoltenberg, M., Gideon, P., Klarlund, M., Jensen, K. E., & Lorenzen, I. (1999) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199905)42:5 · Cited by 323 · see citing works

Regulation of autoantibody activity by the IL-23–TH17 axis determines the onset of autoimmune disease

Pfeifle, R., Rothe, T., Ipseiz, N., Scherer, H. U., Culemann, S., Steffen, U., Ackermann, J. A., Seefried, M., Kleyer, A., Uderhardt, S., et al. (2016) · Nature Immunology · doi:10.1038/ni.3579 · Cited by 320 · see citing works

Identification of an interleukin 17F/17A heterodimer in activated human CD4+ T cells

Wright, J. F., Guo, Y., Quazi, A., Luxenberg, D. P., Bennett, F., Ross, J. F., Qiu, Y., Whitters, M. J., Tomkinson, K. N., Dunussi-Joannopoulos, K., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700499200 · Cited by 319 · see citing works

Identification of a Novel Proinflammatory Human Skin-Homing Vγ9Vδ2 T Cell Subset with a Potential Role in Psoriasis

Laggner, U., Meglio, P. D., Perera, G. K., Hundhausen, C., Lacy, K. E., Ali, N., Smith, C. H., Hayday, A., Nickoloff, B. J., & Nestle, F. O. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100804 · Cited by 316 · see citing works

Secukinumab is superior to ustekinumab in clearing skin of subjects with moderate-to-severe plaque psoriasis up to 1 year: Results from the CLEAR study

Blauvelt, A., Reich, K., Tsai, T., Tyring, S. K., Vanaclocha, F., Kingo, K., Ziv, M., Pinter, A., Vender, R. B., Hugot, S., et al. (2016) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2016.08.008 · Cited by 311 · see citing works

IL-17 Is Produced by Nickel-Specific T Lymphocytes and Regulates ICAM-1 Expression and Chemokine Production in Human Keratinocytes: Synergistic or Antagonist Effects with IFN-γ and TNF-α

Albanesi, C., Cavani, A., & Girolomoni, G. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.1.494 · Cited by 307 · see citing works

Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation

Akimzhanov, A. M., Yang, X. O., & Dong, C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.c600322200 · Cited by 302 · see citing works

IL-17-Producing Alveolar Macrophages Mediate Allergic Lung Inflammation Related to Asthma

Song, C., Luo, L., Zhang, L., Li, B., Liang, Z., Liu, G., Li, D., Zhang, G., Huang, B., & Feng, Z. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.9.6117 · Cited by 301 · see citing works

Prevalence of undiagnosed psoriatic arthritis among psoriasis patients: Systematic review and meta-analysis

Villani, A. P., Rouzaud, M., Sevrain, M., Barnetche, T., Paul, C. F., Richard, M. A., Beylot-Barry, M., Misery, L., Joly, P., Maître, M. L., et al. (2015) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2015.05.001 · Cited by 299 · see citing works

Interleukin‐17+CD8+ T Cells Are Enriched in the Joints of Patients With Psoriatic Arthritis and Correlate With Disease Activity and Joint Damage Progression

Menon, B. S., Gullick, N., Walter, G. J., Rajasekhar, M., Garrood, T., Evans, H. G., Taams, L. S., & Kirkham, B. W. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38376 · Cited by 293 · see citing works

Evidence for a role of IL-17 in organ allograft rejection: IL-17 promotes the functional differentiation of dendritic cell progenitors

Antonysamy, M. A., Fanslow, W. C., Fu, F., Li, W., Qian, S., Troutt, A. B., & Thomson, A. W. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.1.577 · Cited by 293 · see citing works

Long-term safety of secukinumab in patients with moderate-to-severe plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis: integrated pooled clinical trial and post-marketing surveillance data

Deodhar, A. A., Mease, P. J., McInnes, I. B., Baraliakos, X., Reich, K., Blauvelt, A., Leonardi, C., Porter, B. O., Gupta, A. D., Widmer, A., et al. (2019) · Arthritis Research & Therapy · doi:10.1186/s13075-019-1882-2 · Cited by 292 · see citing works

Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis

Cao, Y., Goods, B. A., Raddassi, K., Nepom, G. T., Kwok, W. W., Love, J. C., & Hafler, D. A. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa8038 · Cited by 290 · see citing works

Candida infections in patients with psoriasis and psoriatic arthritis treated with interleukin‐17 inhibitors and their practical management

Saunte, D. M., Mrowietz, U., Puig, L., & Zachariae, C. (2017) · British Journal of Dermatology · doi:10.1111/bjd.15015 · Cited by 280 · see citing works

Efficacy and Safety of MEDI2070, an Antibody Against Interleukin 23, in Patients With Moderate to Severe Crohn’s Disease: A Phase 2a Study

Sands, B. E., Chen, J., Feagan, B. G., Penney, M., Rees, W. A., Danese, S., Higgins, P. D. R., Newbold, P., Faggioni, R., Patra, K., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.03.049 · Cited by 279 · see citing works

Up-Regulation of IL-17 Is Associated with Bioactive IL-8 Expression in Helicobacter pylori -Infected Human Gastric Mucosa

Luzza, F., Parrello, T., Monteleone, G., Sebkova, L., Romano, M., Zarrilli, R., Imeneo, M., & Pallone, F. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.9.5332 · Cited by 270 · see citing works

Cytokines link osteoblasts and inflammation: microarray analysis of interleukin-17- and TNF-α-induced genes in bone cells

Shen, F., Ruddy, M. J., Plamondon, P., & Gaffen, S. L. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0904490 · Cited by 268 · see citing works

IL-17-producing CD8+ T lymphocytes from psoriasis skin plaques are cytotoxic effector cells that secrete Th17-related cytokines

Ortega, C., Fernández, S., Carrillo, J. M., Romero, P., Molina, I. J., Moreno, J. C., & Santamaria, M. L. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0109046 · Cited by 266 · see citing works

The Skin Commensal Yeast Malassezia Triggers a Type 17 Response that Coordinates Anti-fungal Immunity and Exacerbates Skin Inflammation

Sparber, F., De Gregorio, C., Steckholzer, S., Ferreira, F. M., Dolowschiak, T., Ruchti, F., Kirchner, F. R., Mertens, S., Prinz, I., Joller, N., et al. (2019) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2019.02.002 · Cited by 255 · see citing works

Th17 and Th22 cells in psoriatic arthritis and psoriasis

Benham, H., Norris, P. G., GOODALL, J. C., Wechalekar, M. D., FitzGerald, O., Szentpétery, Á., Smith, M., Thomas, R., & Gaston, H. (2013) · Arthritis Research & Therapy · doi:10.1186/ar4317 · Cited by 254 · see citing works

T-bet Regulates the Fate of Th1 and Th17 Lymphocytes in Autoimmunity

Gocke, A. R., Cravens, P. D., Ben, L.-H., Hussain, R. Z., Northrop, S. C., Racke, M. K., & Lovett‐Racke, A. E. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.3.1341 · Cited by 250 · see citing works

CD8+ IL-17-Producing T Cells Are Important in Effector Functions for the Elicitation of Contact Hypersensitivity Responses

He, D., Wu, L., Kim, H. K., Li, H., Elmets, C. A., & Xu, H. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.10.6852 · Cited by 245 · see citing works

Growth Factor FGF2 Cooperates with Interleukin-17 to Repair Intestinal Epithelial Damage

Song, X., Dai, D., He, X., Zhu, S., Yao, Y., Gao, H., Wang, J., Qu, F., Qiu, J., Wang, H., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.06.024 · Cited by 244 · see citing works

β-Defensin 2 is a responsive biomarker of IL-17A–driven skin pathology in patients with psoriasis

Kolbinger, F., Loesche, C., Valentin, M., Jiang, X., Cheng, Y. H., Jarvis, P., Peters, T., Calonder, C., Bruin, G. J. M., Polus, F., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.06.038 · Cited by 239 · see citing works

Activity of secukinumab, an anti-IL-17A antibody, on brain lesions in RRMS: results from a randomized, proof-of-concept study

Havrdová, E., Belova, A. N., Goloborodko, A., Tisserant, A., Wright, A., Wallstroem, E., Garren, H., Maguire, R. P., & Johns, D. R. (2016) · Journal of Neurology · doi:10.1007/s00415-016-8128-x · Cited by 226 · see citing works

Cutting Edge: A Critical Functional Role for IL-23 in Psoriasis

Tonel, G., Conrad, C., Laggner, U., Meglio, P. D., Grys, K., McClanahan, T. K., Blumenschein, W. M., Qin, J., Xin, H., Oldham, E. R., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001538 · Cited by 224 · see citing works

IL-6 Promotes NK Cell Production of IL-17 during Toxoplasmosis

Passos, S., Silver, J. S., O’Hara, A. C., Sehy, D. W., Stumhofer, J. S., & Hunter, C. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901843 · Cited by 223 · see citing works

Efficacy and safety of ustekinumab treatment in adults with moderate‐to‐severe atopic dermatitis

Khattri, S., Brunner, P. M., Garcet, S., Finney, R., Cohen, S. R., Oliva, M., Dutt, R., Fuentes‐Duculan, J., Zheng, X., Li, X., et al. (2016) · Experimental Dermatology · doi:10.1111/exd.13112 · Cited by 213 · see citing works

A phase II randomized study of subcutaneous ixekizumab, an anti-interleukin-17 monoclonal antibody, in rheumatoid arthritis patients who were naive to biologic agents or had an inadequate response to tumor necrosis factor inhibitors

Genovese, M. C., Greenwald, M., Cho, C., Berman, A., Jin, L., Cameron, G. S., Benichou, O., Xie, L., Braun, D., Berclaz, P., et al. (2014) · Arthritis &amp; Rheumatology · doi:10.1002/art.38617 · Cited by 211 · see citing works

Generation and characterization of ixekizumab, a humanized monoclonal antibody that neutralizes interleukin-17A

Liu, L., Kikly, K. K., Lu, J., Allan, B. W., Tang, Y., Tetreault, J. W., Chow, C.-K., Barmettler, B., Nelson, J., Bina, H. A., et al. (2016) · Journal of Inflammation Research · doi:10.2147/jir.s100940 · Cited by 210 · see citing works

Fate-Mapping of GM-CSF Expression Identifies a Discrete Subset of Inflammation-Driving T Helper Cells Regulated by Cytokines IL-23 and IL-1β

Komuczki, J., Tuzlak, S., Friebel, E., Hartwig, T., Spath, S., Rosenstiel, P., Waisman, A., Opitz, L., Oukka, M., Schreiner, B., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.04.006 · Cited by 201 · see citing works

Th17 Cells Induce Colitis and Promote Th1 Cell Responses through IL-17 Induction of Innate IL-12 and IL-23 Production

Feng, T., Qin, H., Wang, L., Benveniste, E. N., Elson, C. O., & Cong, Y. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1001454 · Cited by 200 · see citing works

IL-12 protects from psoriasiform skin inflammation

Kulig, P., Musiol, S., Freiberger, S. N., Schreiner, B., Gyülvészi, G., Russo, G., Pantelyushin, S., Kishihara, K., Alessandrini, F., Kündig, T. M., et al. (2016) · Nature Communications · doi:10.1038/ncomms13466 · Cited by 197 · see citing works

Increased IL-1β, IL-8, and IL-17 mRNA Expression in Blood Mononuclear Cells Observed in a Prospective Ischemic Stroke Study

Kostulas, N., Pelidou, S., Kivisäkk, P., Kostulas, V., & Link, H. (1999) · Stroke · doi:10.1161/01.str.30.10.2174 · Cited by 196 · see citing works

IL-23/IL-17 immunity as a hallmark of Crohnʼs disease

Hölttä, V., Klemetti, P., Sipponen, T. M., Westerholm‐Ormio, M., Kociubinski, G., Salo, H. M., Räsänen, L., Kolho, K., Färkkilä, M. A., Savilahti, E., et al. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20475 · Cited by 196 · see citing works

Incidence rates of inflammatory bowel disease in patients with psoriasis, psoriatic arthritis and ankylosing spondylitis treated with secukinumab: a retrospective analysis of pooled data from 21 clinical trials

Schreiber, S., Colombel, J., Feagan, B. G., Reich, K., Deodhar, A. A., McInnes, I. B., Porter, B. O., Gupta, A. D., Pricop, L., & Fox, T. (2019) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2018-214273 · Cited by 195 · see citing works

Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis

Bowes, J., Budu‐Aggrey, A., Hüffmeier, U., Uebe, S., Steel, K. J. A., Hébert, H. L., Wallace, C., Massey, J., Bruce, I. N., Bluett, J., et al. (2015) · Nature Communications · doi:10.1038/ncomms7046 · Cited by 186 · see citing works

Secukinumab in Active Rheumatoid Arthritis: A Phase III Randomized, Double‐Blind, Active Comparator– and Placebo‐Controlled Study

Blanco, F. J., Möricke, R., Dokoupilova, E., Codding, C., Neal, J., Andersson, M., Rohrer, S., & Richards, H. (2017) · Arthritis &amp; Rheumatology · doi:10.1002/art.40070 · Cited by 185 · see citing works

IL-17 produced by Paneth cells drives TNF-induced shock

Takahashi, N., Vanlaere, I., Rycke, R. M. D., Cauwels, A., Joosten, L. A. B., Lubberts, E., van den Berg, W. B., & Libert, C. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080588 · Cited by 182 · see citing works

Efficacy and safety of guselkumab in patients with active psoriatic arthritis: a randomised, double-blind, placebo-controlled, phase 2 study

Deodhar, A. A., Gottlieb, A. B., Boehncke, W., Dong, B., Wang, Y., Zhuang, Y., Barchuk, W., Xu, X. L., Hsia, E. C., Aelion, J. A., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)30952-8 · Cited by 182 · see citing works

Human mast cells are major IL-22 producers in patients with psoriasis and atopic dermatitis

Mashiko, S., Bouguermouh, S., Rubio, M., Baba, N., Bissonnette, R., & Sarfati, M. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.01.033 · Cited by 180 · see citing works

Increased T Helper Type 17 Response To Pathogen Stimulation in Patients With Primary Sclerosing Cholangitis

Katt, J., Schwinge, D., Schoknecht, T., Quaas, A., Sobottka, I., Burandt, E., Becker, C., Neurath, M. F., Lohse, A. W., Herkel, J., et al. (2013) · Hepatology · doi:10.1002/hep.26447 · Cited by 175 · see citing works

Chronic mucocutaneous candidiasis disease associated with inborn errors of IL‐17 immunity

Okada, S., Puel, A., Casanova, J., & Kobayashi, M. (2016) · Clinical & Translational Immunology · doi:10.1038/cti.2016.71 · Cited by 175 · see citing works

Th17 Cytokines Regulate Osteoclastogenesis in Rheumatoid Arthritis

Kim, K., Kim, H., Kim, B., Cho, M., & Lee, S. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.07.017 · Cited by 162 · see citing works

Gamma/delta T cells are the predominant source of interleukin‐17 in affected joints in collagen‐induced arthritis, but not in rheumatoid arthritis

Ito, Y., Usui, T., Kobayashi, S., Iguchi-Hashimoto, M., Ito, H., Yoshitomi, H., Nakamura, T., Shimizu, M., Kawabata, D., Yukawa, N., et al. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24687 · Cited by 160 · see citing works

Risankizumab in patients with moderate to severe Crohn's disease: an open-label extension study

Feagan, B. G., Panés, J., Ferrante, M., Kaser, A., D’Haens, G., Sandborn, W. J., Louis, E. J., Neurath, M. F., Franchimont, D. P., Dewit, O., et al. (2018) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(18)30233-4 · Cited by 158 · see citing works

Dysregulation of the Cytokine GM‐CSF Induces Spontaneous Phagocyte Invasion and Immunopathology in the Central Nervous System

Spath, S., Komuczki, J., Hermann, M., Pelczar, P., Mair, F., Schreiner, B., & Becher, B. (2017) · Immunity · doi:10.1016/j.immuni.2017.01.007 · Cited by 157 · see citing works

Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing Treg cells through modification of the intestinal microbiota

Tang, C., Kakuta, S., Shimizu, K., Kadoki, M., Kamiya, T., Shimazu, T., Kubo, S., Saijo, S., Ishigame, H., Nakae, S., et al. (2018) · Nature Immunology · doi:10.1038/s41590-018-0134-y · Cited by 152 · see citing works

Human T h17 subsets

Sallusto, F., Zielinski, C. E., & Lanzavecchia, A. (2012) · European Journal of Immunology · doi:10.1002/eji.201242741 · Cited by 151 · see citing works

A randomised phase II study evaluating the efficacy and safety of subcutaneously administered ustekinumab and guselkumab in patients with active rheumatoid arthritis despite treatment with methotrexate

Smolen, J. S., Agarwal, S. K., Ilivanova, E. P., Xu, X. L., Ye, M., Zhuang, Y., Nnane, I. P., Radziszewski, W., Greenspan, A. J., Beutler, A. M., et al. (2017) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2016-209831 · Cited by 141 · see citing works

Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis

Hu, D., Notarbartolo, S., Croonenborghs, T., Patel, B., Cialic, R., Yang, T.-H., Aschenbrenner, D., Andersson, K., Gattorno, M., Pham, M., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01571-8 · Cited by 138 · see citing works

Comparative Genomic Profiling of Synovium Versus Skin Lesions in Psoriatic Arthritis

Belasco, J., Louie, J. S., Gulati, N., Wei, N., Nograles, K. E., Fuentes‐Duculan, J., Mitsui, H., Suárez‐Fariñas, M., & Krueger, J. G. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38995 · Cited by 122 · see citing works

Brief Report: Enrichment of Activated Group 3 Innate Lymphoid Cells in Psoriatic Arthritis Synovial Fluid

Leijten, E. F. A., van Kempen, T. S., Boes, M. L., Amelsfort, J. M. R. M.-V., Hijnen, D., Hartgring, S. A. Y., van Roon, J. A. G., Wenink, M. H., & Radstake, T. R. D. J. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39261 · Cited by 117 · see citing works

Efficacy and safety of ustekinumab in Japanese patients with severe atopic dermatitis: a randomized, double-blind, placebo-controlled, phase II study

Saeki, H., Kabashima, K., TOKURA, Y., Murata, Y., Shiraishi, A., Tamamura, R., Randazzo, B. P., & Imanaka, K. (2017) · British Journal of Dermatology · doi:10.1111/bjd.15493 · Cited by 116 · see citing works

IL-6 Regulates Neutrophil Microabscess Formation in IL-17A-Driven Psoriasiform Lesions

Croxford, A. L., Karbach, S. H., Kurschus, F. C., Wörtge, S., Nikolaev, A., Yogev, N., Klebow, S., Schüler, R., Reißig, S., Piotrowski, C., et al. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.404 · Cited by 114 · see citing works

PATHWAYS BY WHICH INTERLEUKIN 17 INDUCES ARTICULAR CARTILAGE BREAKDOWN IN VITRO AND IN VIVO

Cai, L., Yin, J., Starovasnik, M. A., Hogue, D. A., Hillan, K. J., Mort, J. S., & Filvaroff, E. H. (2001) · Cytokine · doi:10.1006/cyto.2001.0939 · Cited by 107 · see citing works

Ixekizumab provides superior efficacy compared with ustekinumab over 52 weeks of treatment: Results from IXORA-S, a phase 3 study

Paul, C. F., Griffiths, C. E. M., van de Kerkhof, P. C. M., Puig, L., Dutronc, Y., Henneges, C., Dossenbach, M. R. K., Hollister, K., & Reich, K. (2018) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2018.06.039 · Cited by 103 · see citing works

Long‐term efficacy of novel therapies in moderate‐to‐severe plaque psoriasis: a systematic review and network meta‐analysis of PASI response

Sawyer, L., Cornic, L., Levin, L. Å., Gibbons, C. M., Møller, A. H., & Jemec, G. B. E. (2018) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.15277 · Cited by 103 · see citing works

High in vivo expression of interleukin‐17 receptor in synovial endothelial cells and chondrocytes from arthritis patients

Honorati, M. C., Meliconi, R., Pulsatelli, L., Canè, S., Frizziero, L., & Facchini, A. (2001) · Rheumatology · doi:10.1093/rheumatology/40.5.522 · Cited by 99 · see citing works

Phase II Study of ABT ‐122, a Tumor Necrosis Factor– and Interleukin‐17A–Targeted Dual Variable Domain Immunoglobulin, in Patients With Psoriatic Arthritis With an Inadequate Response to Methotrexate

Mease, P. J., Genovese, M. C., Weinblatt, M. E., Peloso, P. M. J., Chen, K., Othman, M. I. A., Li, Y., Mansikka, H. T., Khatri, A., Wishart, N., et al. (2018) · Arthritis & Rheumatology · doi:10.1002/art.40579 · Cited by 98 · see citing works

Development of Proteoglycan-Induced Arthritis Is Independent of IL-17

Doodes, P. D., Cao, Y., Hamel, K. M., Wang, Y., Farkas, B., Iwakura, Y., & Finnegan, A. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.1.329 · Cited by 97 · see citing works

The Initiation, but Not the Persistence, of Experimental Spondyloarthritis Is Dependent on Interleukin-23 Signaling

van Tok, M. N., Na, S., Lao, C. R., Alvi, M., Pots, D., van de Sande, M. G. H., Taurog, J. D., Sedgwick, J. D., Baeten, D., & van Duivenvoorde, L. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01550 · Cited by 84 · see citing works

A study to evaluate the safety, tolerability, and efficacy of brodalumab in subjects with rheumatoid arthritis and an inadequate response to methotrexate

Pavelka, K., Chon, Y., Newmark, R., Lin, S.-L., Baumgartner, S., & Erondu, N. (2015) · The Journal of Rheumatology · doi:10.3899/jrheum.141271 · Cited by 83 · see citing works

Serum interleukin 17, interleukin 23, and interleukin 10 values in children with atopic eczema/dermatitis syndrome (AEDS): Association with clinical severity and phenotype

Leonardi, S., Cuppari, C., Manti, S., Filippelli, M., Parisi, G. F., Borgia, F., Briuglia, S., Cannavó, P. S., Salpietro, A., Arrigo, T., et al. (2014) · Allergy and Asthma Proceedings · doi:10.2500/aap.2015.36.3808 · Cited by 80 · see citing works

Safety of tildrakizumab for moderate-to-severe plaque psoriasis: pooled analysis of three randomized controlled trials

Blauvelt, A., Reich, K., Papp, K. A., Kimball, A. B., Gooderham, M., Tyring, S. K., Sinclair, R. D., Thaçi, D., Li, Q., Cichanowitz, N., et al. (2018) · British Journal of Dermatology · doi:10.1111/bjd.16724 · Cited by 76 · see citing works

IL‐23‐driven encephalo‐tropism and Th17 polarization during CNS‐inflammation in vivo

Gyülvészi, G., Haak, S., & Becher, B. (2009) · European Journal of Immunology · doi:10.1002/eji.200939305 · Cited by 73 · see citing works

Neutrophils Are Essential As A Source Of Il-17 In The Effector Phase Of Arthritis

Katayama, M., Ohmura, K., Yukawa, N., Terao, C., Hashimoto, M., Yoshifuji, H., Kawabata, D., Fujii, T., Iwakura, Y., & Mimori, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062231 · Cited by 66 · see citing works

Safety of Ixekizumab in Patients With Psoriatic Arthritis: Results From a Pooled Analysis of Three Clinical Trials

Mease, P. J., Roussou, E., Burmester, G. R., Goupille, P., Gottlieb, A. B., Moriarty, S. R., Bénichou, O., Adams, D. H., Xu, W., & Nash, P. T. (2018) · Arthritis Care & Research · doi:10.1002/acr.23738 · Cited by 65 · see citing works

A phase 2, 24-week, randomized, placebo-controlled, double-blind study examining the efficacy and safety of an anti-interleukin-12 and -23 monoclonal antibody in patients with relapsing–remitting or secondary progressive multiple sclerosis

Vollmer, T. L., Wynn, D. R., Alam, M. S., & Valdes, J. M. (2010) · Multiple Sclerosis Journal · doi:10.1177/1352458510384496 · Cited by 64 · see citing works

Psoriasiform architecture of murine epidermis overlying human psoriatic dermis transplanted onto SCID mice

Boehncke, W., Sterry, W., Hainzl, A., Scheffold, W., & Kaufmann, R. (1994) · Archives of Dermatological Research · doi:10.1007/bf00402223 · Cited by 62 · see citing works

Long‐term safety profile of ixekizumab in patients with moderate‐to‐severe plaque psoriasis: an integrated analysis from 11 clinical trials

Langley, R. G. B., Kimball, A. B., Nak, H., Xu, W., Pangallo, B. A., Osuntokun, O. O., Agada, N. O., & Reich, K. (2018) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.15242 · Cited by 61 · see citing works

Characterization of Skin-Infiltrating Lymphocytes in Patients with Psoriasis

Nikaein, A., Phillips, C. M., Gilbert, S. C., Savino, D. A., Silverman, A., Stone, M. J., & Menter, A. (1991) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12514646 · Cited by 59 · see citing works

A Reappraisal on the Potential Ability of Human Neutrophils to Express and Produce IL-17 Family Members In Vitro: Failure to Reproducibly Detect It

Tamassia, N., Arruda-Silva, F., Calzetti, F., Lonardi, S., Gasperini, S., Gardiman, E., Bianchetto-Aguilera, F. M., Gatta, L. B., Girolomoni, G., Mantovani, A., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00795 · Cited by 58 · see citing works

Differential Effects of IL-17A and TNF-α on Osteoblastic Differentiation of Isolated Synoviocytes and on Bone Explants from Arthritis Patients

Osta, B., Roux, J.-P., Lavocat, F., Pierre, M., Ndongo-Thiam, N., Boivin, G., & Miossec, P. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00151 · Cited by 54 · see citing works

IL-17A, IL-22, and IL-23 as Markers of Psoriasis Activity

Fotiadou, C., Lazaridou, E., Sotiriou, E., Gerou, S., Kyrgidis, Α., Vakirlis, E., & Ioannides, D. (2015) · Journal of Cutaneous Medicine and Surgery · doi:10.1177/1203475415584503 · Cited by 53 · see citing works

Expression of interleukin‐17 in primary Sjögren's syndrome and the correlation with disease severity: A systematic review and meta‐analysis

Zhang, L. ‐., Zhou, P., Wei, P., Cong, X., Wu, L., & Hua, H. (2018) · Scandinavian Journal of Immunology · doi:10.1111/sji.12649 · Cited by 51 · see citing works

Psoriatic inflammation facilitates the onset of arthritis in a mouse model.

Yamamoto, M., Nakajima, K., Takaishi, M., Kitaba, S., Magata, Y., Kataoka, S., & Sano, S. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.426 · Cited by 49 · see citing works

B Cells Contribute to Heterogeneity of IL-17 Producing Cells in Rheumatoid Arthritis and Healthy Controls

Schlegel, P. M., Steiert, I., Kötter, I., & Müller, C. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082580 · Cited by 48 · see citing works

Modulation of IL-17 and Foxp3 Expression in the Prevention of Autoimmune Arthritis in Mice

Duarte, J., Agua‐Doce, A., Oliveira, V. G., Fonseca, J. E., & Graça, L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010558 · Cited by 46 · see citing works

IL-17A and IL-17F Expression in B Lymphocytes

Vazquez‐Tello, A., Halwani, R., Li, R., Nadigel, J., Bar-Or, A., Mazer, B. D., Eidelman, D. H., Al‐Muhsen, S., & Hamid, Q. A. (2011) · International Archives of Allergy and Immunology · doi:10.1159/000329527 · Cited by 41 · see citing works

Efficacy and Safety of Switching to Ixekizumab in Etanercept Non-Responders: A Subanalysis from Two Phase III Randomized Clinical Trials in Moderate-to-Severe Plaque Psoriasis (UNCOVER-2 and -3)

Blauvelt, A., Papp, K. A., Griffiths, C. E. M., Puig, L., Weisman, J. D., Dutronc, Y., Kerr, L. F., Ilo, D., Mallbris, L., & Augustin, M. (2017) · American Journal of Clinical Dermatology · doi:10.1007/s40257-016-0246-9 · Cited by 38 · see citing works

Secukinumab provides sustained PASDAS-defined remission in psoriatic arthritis and improves health-related quality of life in patients achieving remission: 2-year results from the phase III FUTURE 2 study

on behalf of the FUTURE 2 study group, Coates, L. C., Gladman, D. D., Nash, P. T., FitzGerald, O., Kavanaugh, A., Kvien, T. K., Gossec, L., Strand, V., Rasouliyan, L., et al. (2018) · Arthritis Research & Therapy · doi:10.1186/s13075-018-1773-y · Cited by 38 · see citing works

Challenges, Progress, and Prospects of Developing Therapies to Treat Autoimmune Diseases

Fugger, L. H., Jensen, L. T., & Rossjohn, J. (2020) · Cell · doi:10.1016/j.cell.2020.03.007 · Cited by 403 · see citing works

TH17 cell heterogeneity and its role in tissue inflammation

Schnell, A., Littman, D. R., & Kuchroo, V. K. (2023) · Nature Immunology · doi:10.1038/s41590-022-01387-9 · Cited by 286 · see citing works

Repositioning TH cell polarization from single cytokines to complex help

Tuzlak, S., Dejean, A. S., Iannacone, M., Quintana, F. J., Waisman, A., Ginhoux, F., Korn, T., & Becher, B. (2021) · Nature Immunology · doi:10.1038/s41590-021-01009-w · Cited by 171 · see citing works

Cell death in chronic inflammation: breaking the cycle to treat rheumatic disease

Anderton, H., Wicks, I. P., & Silke, J. (2020) · Nature Reviews Rheumatology · doi:10.1038/s41584-020-0455-8 · Cited by 145 · see citing works

Natural Anti-Inflammatory Compounds as Drug Candidates for Inflammatory Bowel Disease

Duan, L., Cheng, S.-Y., Li, L., Liu, Y., Wang, D., & Liu, G. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.684486 · Cited by 124 · see citing works

Skin immunity: dissecting the complex biology of our body's outer barrier

Zhang, C., Merana, G. R., Harris-Tryon, T. A., & Scharschmidt, T. C. (2022) · Mucosal Immunology · doi:10.1038/s41385-022-00505-y · Cited by 118 · see citing works

Much More Than IL-17A: Cytokines of the IL-17 Family Between Microbiota and Cancer

Brevi, A., Cogrossi, L. L., Grazia, G., Masciovecchio, D., Impellizzieri, D., Lacanfora, L., Grioni, M., & Bellone, M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.565470 · Cited by 113 · see citing works

Signalling, sorting and scaffolding adaptors for Toll-like receptors

Luo, L., Lucas, R. M., Liu, L., & Stow, J. L. (2019) · Journal of Cell Science · doi:10.1242/jcs.239194 · Cited by 100 · see citing works

Decoding IL-23 Signaling Cascade for New Therapeutic Opportunities

Pastor-Fernández, G., Mariblanca, I. R., & Navarro, M. N. (2020) · Cells · doi:10.3390/cells9092044 · Cited by 95 · see citing works

Immunity to commensal skin fungi promotes psoriasiform skin inflammation

Hurabielle, C., Link, V. M., Bouladoux, N., Han, S.-J., Merrill, E. D., Lightfoot, Y. L., Seto, N., Bleck, C. K. E., Smelkinson, M., Harrison, O. J., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2003022117 · Cited by 97 · see citing works

The Immunomodulatory and Anti-Inflammatory Effect of Curcumin on Immune Cell Populations, Cytokines, and In Vivo Models of Rheumatoid Arthritis

Makuch, S., Więcek, K., & Woźniak, M. (2021) · Pharmaceuticals · doi:10.3390/ph14040309 · Cited by 92 · see citing works

Organizing structural principles of the IL-17 ligand–receptor axis

Wilson, S. C., Caveney, N. A., Yen, M., Pollmann, C., Xiang, X., Jude, K. M., Hafer, M., Tsutsumi, N., Piehler, J., & García, K. C. (2022) · Nature · doi:10.1038/s41586-022-05116-y · Cited by 87 · see citing works

Th17 Cells in Periodontitis and Its Regulation by A20

Huang, N., Dong, H., Luo, Y., & Shao, B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.742925 · Cited by 78 · see citing works

Human TH17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation

Chao, Y.-Y., Puhach, A., Frieser, D., Arunkumar, M., Lehner, L., Seeholzer, T., López, A. G., van der Wal, M., Fibi-Smetana, S., Dietschmann, A., et al. (2023) · Nature Immunology · doi:10.1038/s41590-022-01386-w · Cited by 74 · see citing works

An autonomous activation of interleukin-17 receptor signaling sustains inflammation and promotes disease progression

Luo, Q., Liu, Y., Shi, K., Shen, X., Yang, Y., Liang, X., Lu, L., Qiao, W., Chen, A., Hong, D., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.06.012 · Cited by 74 · see citing works

Lipid metabolism in Th17 cell function

Kanno, T., Nakajima, T., Miyako, K., & Endo, Y. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108411 · Cited by 67 · see citing works

IL-23 stabilizes an effector Treg cell program in the tumor microenvironment

Wertheimer, T., Zwicky, P., Rindlisbacher, L., Sparano, C., Vermeer, M., de Melo, B. M. S., Haftmann, C., Rückert, T., Sethi, A., Schärli, S., et al. (2024) · Nature Immunology · doi:10.1038/s41590-024-01755-7 · Cited by 68 · see citing works

IL-17: Balancing Protective Immunity and Pathogenesis

Sun, L., Wang, L., Moore, B. B., Zhang, S., Xiao, P., Decker, A. M., & Wang, H. (2023) · Journal of Immunology Research · doi:10.1155/2023/3360310 · Cited by 60 · see citing works

Targeting cytokine networks in neuroinflammatory diseases

Becher, B., Derfuss, T. J., & Liblau, R. (2024) · Nature Reviews Drug Discovery · doi:10.1038/s41573-024-01026-y · Cited by 53 · see citing works

Expression of interleukin‐17 in primary Sjögren's syndrome and the correlation with disease severity: A systematic review and meta‐analysis

Zhang, L. ‐., Zhou, P., Wei, P., Cong, X., Wu, L., & Hua, H. (2018) · Scandinavian Journal of Immunology · doi:10.1111/sji.12649 · Cited by 51 · see citing works

Synthesis and identification of lithocholic acid 3-sulfate as RORγt ligand to inhibit Th17 cell differentiation

Xiao, R., Lei, K., Kuok, H., Deng, W., Zhuang, Y., Tang, Y., Guo, Z., Qin, H., Bai, L.-P., & Li, T. (2022) · Journal of Leukocyte Biology · doi:10.1002/jlb.1ma0122-513r · Cited by 41 · see citing works

Immunopathogenesis and distinct role of Th17 in Periodontitis: A review.

Kini, V., Mohanty, I., Telang, G., & Vyas, N. (2022) · Journal of Oral Biosciences · doi:10.1016/j.job.2022.04.005 · Cited by 37 · see citing works

A synergistic effect of triptolide and curcumin on rheumatoid arthritis by improving cell proliferation and inducing cell apoptosis via inhibition of the IL-17/NF-κB signaling pathway

Zhang, C., Weng, Y., Wang, H., Zhan, S., Li, C., Zheng, D., & Qi, L. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112953 · Cited by 32 · see citing works

Interplay of Microbiota and Citrullination in the Immunopathogenesis of Rheumatoid Arthritis

Alghamdi, M. A., & Redwan, E. M. M. M. (2021) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-021-09802-7 · Cited by 31 · see citing works

Interleukin-17 mediated immunity during infections with Trypanosoma cruzi and other protozoans

Vesely, M. C. A., Rodríguez, C., Gruppi, A., & Rodríguez, E. V. A. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165706 · Cited by 33 · see citing works

Regulation of tissue immune responses by local glucocorticoids at epithelial barriers and their impact on interorgan crosstalk

Merk, V. M., Phan, T. S., & Brunner, T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.672808 · Cited by 27 · see citing works

Fragile Treg cells: traitors in immune homeostasis?

Song, X., Chen, R., Li, J., Zhu, Y., Jiao, J., Liu, H., Chen, Z.-N., & Geng, J. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107297 · Cited by 28 · see citing works

Lactococcus lactis as an Interleukin Delivery System for Prophylaxis and Treatment of Inflammatory and Autoimmune Diseases

Campos, G. M., Américo, M. F., Freitas, A. D. S., Barroso, F. A. L., Dutra, J. D. C. F., Quaresma, L. S., Cordeiro, B. F., Laguna, J. G., de Jesus, L. C. L., Fontes, A. M., et al. (2023) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-023-10041-1 · Cited by 27 · see citing works

Slit2 May Underlie Divergent Induction by Thyrotropin of IL-23 and IL-12 in Human Fibrocytes

Fernando, R., Atkins, S. J., & Smith, T. J. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1900434 · Cited by 22 · see citing works

Therapeutic efficacy of IL-17A neutralization with corticosteroid treatment in a model of antigen-driven mixed-granulocytic asthma

Menson, K. E., Mank, M. M., Reed, L. F., Walton, C. J., Vliet, K. E. V. D., Ather, J. L., Chapman, D. G., Smith, B. J., Rincón, M., & Poynter, M. E. (2020) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00204.2020 · Cited by 22 · see citing works

Hypersensitivity and Immune-related Adverse Events in Biologic Therapy

Waldron, J. L., Schworer, S. A., & Kwan, M. (2021) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-021-08879-w · Cited by 22 · see citing works

IL-34 affects fibroblast-like synoviocyte proliferation, apoptosis and function by regulating IL-17

Li, X., Lei, Y., Gao, Z., Wu, G., Gao, W., Xia, L., Lu, J., & Shen, H. (2021) · Scientific Reports · doi:10.1038/s41598-021-95839-1 · Cited by 20 · see citing works

Neuro-immune crosstalk in depressive symptoms of multiple sclerosis

Wang, C., Zhou, Y., & Feinstein, A. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106005 · Cited by 19 · see citing works

Multifaceted roles of IL-17 in bone and tendon health

Shen, J., Chen, Y., Zhang, Y. H., Zhang, C., & Liu, H. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.139498 · Cited by 16 · see citing works

Allo-lithocholic acid, a microbiome derived secondary bile acid, attenuates liver fibrosis

Marchianò, S., Biagioli, M., Giorgio, C. D., Massa, C., Bellini, R., Bordoni, M., Urbani, G., Lachi, G., Sepe, V., Morretta, E., et al. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.116883 · Cited by 16 · see citing works

PLGA microspheres carrying miR-20a-5p improved intestinal epithelial barrier function in patients with Crohn’s disease through STAT3-mediated inhibition of Th17 differentiation

Wang, H., Xing, H., Xia, Y., Zhou, Y., Zhou, J., Li, L., Tao, W., Liu, Q., Wang, Y., Zhao, J., et al. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109025 · Cited by 16 · see citing works

Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site

Goedken, E. R., Argiriadi, M. A., Dietrich, J. D., Petros, A. M., Krishnan, N., Panchal, S. C., Qiu, W., Wu, H., Zhu, H., Adams, A. M., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-18760-1 · Cited by 16 · see citing works

IL-17-related signature genes linked to human necrotizing enterocolitis

Tremblay, É., Ferretti, E., Babakissa, C., Burghardt, K. M., Levy, E. H., & Beaulieu, J. (2021) · BMC Research Notes · doi:10.1186/s13104-021-05489-9 · Cited by 16 · see citing works

Immunological Effects of Anti‒IL-17/12/23 Therapy in Patients with Psoriasis Complicated by Candida Infections

Bruno, M., Davidson, L., Koenen, H. J. P. M., van den Reek, J. M. P. A., van Cranenbroek, B., de Jong, E. M. G. J., van de Veerdonk, F. L., Kullberg, B. J., & Netea, M. G. (2022) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2022.05.1083 · Cited by 15 · see citing works

Cyanidin prevents MDPV withdrawal-induced anxiety-like effects and dysregulation of cytokine systems in rats

Inan, S., Meissler, J. J., Shekarabi, A., Foss, J., Wiah, S., Eisenstein, T. K., & Rawls, S. M. (2023) · Brain Research · doi:10.1016/j.brainres.2023.148310 · Cited by 14 · see citing works

Oroxylin A attenuates psoriasiform skin inflammation by direct targeting p62 (sequestosome 1) via suppressing M1 macrophage polarization

Ma, Y., Liu, Y., Zhong, Y. J., Li, X., Xu, Y., Chen, L., Gong, L., Huang, H., Chen, X., He, Y., et al. (2024) · British Journal of Pharmacology · doi:10.1111/bph.17349 · Cited by 14 · see citing works

Topical Formulation of Noscapine, a Benzylisoquinoline Alkaloid, Ameliorates Imiquimod-Induced Psoriasis-Like Skin Lesions

Nourbakhsh, F., Mousavi, S. H., Rahmanian‐Devin, P., Rahimi, V. B., Rakhshandeh, H., & Askari, V. R. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/3707647 · Cited by 13 · see citing works

Beyond type 2 cytokines in asthma - new insights from old clinical trials

Choy, D. F., & Arron, J. R. (2020) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2020.1744567 · Cited by 13 · see citing works

Regulation of signaling pathways by metal and metal-doped nanozymes in inflammatory bowel disease: A therapeutic perspective

Govindarasu, M., Joy, J. G., Sharma, G., & Kim, J. (2025) · Nano Today · doi:10.1016/j.nantod.2025.102747 · Cited by 12 · see citing works

Triggering Receptor Expressed on Myeloid Cells-2 Protects Aged Mice Against Sepsis by Mitigating the IL-23/IL-17A Response

Chen, Q., Yang, Y., Wu, X., Yang, S., Zhang, Y., Shu, Q., & Fang, X. (2020) · Shock · doi:10.1097/shk.0000000000001668 · Cited by 12 · see citing works

MicroRNA-26b-5p alleviates murine collagen-induced arthritis by modulating Th17 cell plasticity

Zhang, M.-F., Yang, P., Shen, M.-Y., Wang, X., Gao, N.-X., Zhou, X., Zhou, L., & Lü, Y. (2021) · Cellular Immunology · doi:10.1016/j.cellimm.2021.104382 · Cited by 12 · see citing works

Helminth-derived cystatins: the immunomodulatory properties of an Ascaris lumbricoides cystatin

Caraballo, L. R., Zakzuk, J., & Acevedo, N. (2021) · Parasitology · doi:10.1017/s0031182021000214 · Cited by 11 · see citing works

Inflammation-Driven Molecular Ageing in Chronic Inflammatory Skin Diseases: Is There a Role for Biologic Therapies?

Andrzejczak, K., Sternak, A., Witkowski, W., & Ponikowska, M. (2025) · Cells · doi:10.3390/cells14181442 · Cited by 10 · see citing works

Two Epitope Regions Revealed in the Complex of IL-17A and Anti-IL-17A VHH Domain

Kostareva, O. S., Svoeglazova, A., Kolyadenko, I., Никулин, А. Д., Evdokimov, S., Dzhus, U. F., Gabdulkhakov, A. G., & Tishchenko, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314904 · Cited by 10 · see citing works

Discovery of a Novel Class of Dual GPBAR1 Agonists–RORγt Inverse Agonists for the Treatment of IL-17-Mediated Disorders

Fiorillo, B., Roselli, R., Finamore, C., Biagioli, M., Giorgio, C. D., Bordoni, M., Conflitti, P., Marchianò, S., Bellini, R., Rapacciuolo, P., et al. (2023) · ACS Omega · doi:10.1021/acsomega.2c07907 · Cited by 10 · see citing works

Antinociceptive interactions between excitatory interferon-γ and interleukin-17 in sensory neurons

Natura, G., Vazquez, E., Richter, F., von Banchet, G. S., Ebbinghaus, M., Ebersberger, A., König, C., Maltritz, J., Gajda, M. R., Schmidt‐Hieber, C., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.11.021 · Cited by 10 · see citing works

Aureane-type sesquiterpene tetraketides as a novel class of immunomodulators with interleukin-17A inhibitory activity

Tang, X., Wang, C., Wang, L., Ren, F., Kuang, R., Li, Z., Han, X., Chen, Y., Chen, G., Wu, X., et al. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.03.017 · Cited by 10 · see citing works

Berry Extracts and Their Bioactive Compounds Mitigate LPS and DNFB-Mediated Dendritic Cell Activation and Induction of Antigen Specific T-Cell Effector Responses

Upadhaya, P., Lamenza, F. F., Shrestha, S., Roth, P., Jagadeesha, S., Pracha, H., Horn, N. A., & Oghumu, S. (2023) · Antioxidants · doi:10.3390/antiox12091667 · Cited by 10 · see citing works

The pathogenetic role of Th17 immune response in atopic dermatitis

David, E., & Czarnowicki, T. (2023) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0000000000000926 · Cited by 9 · see citing works

Silencing long noncoding RNA-CES1P1 suppresses glomerular endothelial cell inflammation in diabetic nephropathy

Zhang, X., Ren, L., Wei, J., Ni, Y., Sun, L., Zhao, X., Zhang, Y., & Qiao, H. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108820 · Cited by 9 · see citing works

Immunosuppressive Therapies in Pulmonary Sarcoidosis: A Practical, Evidence-Based Review

Dhanani, Z., & Gupta, R. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14196828 · Cited by 8 · see citing works

CD4+ T cell membrane-based nanocomposites for enhanced dual epigenetic therapy in psoriasis

Hou, L., Wang, N., Miao, Q., Wang, Z., & Yan, F. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.05.067 · Cited by 7 · see citing works

Integrated analysis of metabolomics, network pharmacology, and intestinal microbiota reveals Tibetan herb E’se ameliorate disorders of glycolipid metabolism in db/db mice

Zheng, L., Liu, L., An, S. Y., Chen, X., Hua, H., & Zhao, J. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156979 · Cited by 8 · see citing works

The IL‐23/IL‐17/NF‐κB Signaling Pathway in Rheumatoid Arthritis: Molecular Mechanisms and Therapeutic Agents

Deng, J., Deng, Y., Chen, Y., Bai, F., Zhang, B., Jiang, W., Wang, W., & Yu, H. (2025) · Medicinal Research Reviews · doi:10.1002/med.70024 · Cited by 7 · see citing works

The role of interleukin 17 in the pathogenesis of rheumatoid arthritis. Are there any prospects for the use of IL-17 inhibitors?

Nasonov, E. L., Avdeeva, A. S., Korotaeva, T. V., Дубинина, Т. В., & Usacheva, J. V. (2023) · Rheumatology Science and Practice · doi:10.47360/1995-4484-2023-165-180 · Cited by 7 · see citing works

RKC-B1 Blocks Activation of NF-κB and NLRP3 Signaling Pathways to Suppress Neuroinflammation in LPS-Stimulated Mice

Liu, M., Yang, Y., Zhang, S., Liu, D.-N., Fang, L., Du, G., & Wang, Y. (2021) · Marine Drugs · doi:10.3390/md19080429 · Cited by 7 · see citing works

Advances in pharmacotherapy for immunoinflammatory rheumatic diseases in the 21st century

Nasonov, E. L. (2025) · Terapevticheskii arkhiv · doi:10.26442/00403660.2025.05.203213 · Cited by 6 · see citing works

The immunological pathogenesis of vitiligo and the potential role of mesenchymal stromal/stem cells in its treatment

Yang, R., Zhao, D., Yang, Y., Wei, H.-X., Yang, K., Zhao, Y., Wan, W.-H., Liu, Z.-L., Feng, Y., Zhang, Q., et al. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06627-8 · Cited by 8 · see citing works

The role of interleukin‐17 (IL‐17) in the pathogenesis of discoid lupus erythematosus and lichen planopilaris: is immunohistochemistry for IL‐17 a promising way to differentiate these entities?

Shahidi‐Dadras, M., Rakhshan, A., Dadkhahfar, S., & Barat, T. (2021) · International Journal of Dermatology · doi:10.1111/ijd.15885 · Cited by 6 · see citing works

Distinct Th17 effector cytokines differentially promote microglial and blood-brain barrier inflammatory responses during post-infectious encephalitisPreprint

Wayne, C. R., Bremner, L., Faust, T. E., Durán‐Laforet, V., Ampatey, N., Ho, S. J., Feinberg, P. A., Arvanitis, P., Ćirić, B., Ruan, C., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.10.532135 · Cited by 6 · see citing works

Golden berry leaf extract containing withanolides suppresses TNF-α and IL-17 induced IL-6 expression in HeLa Cells.

Yano, A., Yuki, S., Shiraishi, A., Hakozaki, M., Kanno, Y., Ken-ichi, K., & Uesugi, S. (2023) · Bioscience, biotechnology and biochemistry · doi:10.1093/bbb/zbad070 · Cited by 5 · see citing works

Cytokines and Transgenic Matrix in Autoimmune Diseases: Similarities and Differences

Szewczak, L., & Donskow-Łysoniewska, K. (2020) · Biomedicines · doi:10.3390/biomedicines8120559 · Cited by 7 · see citing works

Structural basis for ACT1 oligomerization induced by IL-17 receptor hetero-tetramer

Zhang, H., Bai, X.-C., & Zhang, X. (2025) · Nature Communications · doi:10.1038/s41467-025-67536-4 · Cited by 4 · see citing works

Microbiota metabolite lithocholic acid in cancer: Mechanisms and therapeutic potential

Darmadi, D., Muhame, A. J., Gerasimov, S. G., Mirzaei, R., & Karampoor, S. (2026) · Experimental Cell Research · doi:10.1016/j.yexcr.2026.114981 · Cited by 4 · see citing works

Nanobody therapeutics in autoimmune and immune-mediated inflammatory diseases: experimental insights and translational strategies

Sherbaevna, S. R. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115552 · Cited by 3 · see citing works

IL-17A expression by both T cells and non-T cells contribute to HSV-IL-2-induced CNS demyelination

Hirose, S., Wang, S., Jaggi, U., Matundan, H. H., Kato, M., Song, X.-Y., Molesworth-Kenyon, S. J., Lausch, R. N., & Ghiasi, H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1102486 · Cited by 3 · see citing works

Increased colorectal cancer risk in prediabetes: A meta-analysis

Wang, N., Zhao, T.-Y., & Ma, X. (2025) · World Journal of Diabetes · doi:10.4239/wjd.v16.i5.103403 · Cited by 2 · see citing works

IL-17 Receptor inhibition with brodalumab limits experimental periodontitis

Valverde, A. M., Naqvi, R. A., Tokarski, M., Ceredon, K., Gluck, J., Elshourbagy, S., Martínez, G., Brambilla, M., Nares, S., Schwartz, J., et al. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08657-2 · Cited by 2 · see citing works

Structural basis of interleukin-17B receptor in complex with a neutralizing antibody for guiding humanization and affinity maturation

Lee, W.-H., Chen, X., Liu, I.-J., Lee, J.-H., Wu, H., Wu, H., Wang, S., Lee, W., & Ma, C. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111555 · Cited by 2 · see citing works

FGF7 as an essential mediator for the onset of ankylosing enthesitis related to psoriatic dermatitis

Ebihara, S., Owada, Y., & Ono, M. (2025) · Life Science Alliance · doi:10.26508/lsa.202403073 · Cited by 1 · see citing works

The role of IL-17 family in the process of pulmonary fibrosis

Zhou, G., Li, A., & Wang, R. (2025) · Life Conflux · doi:10.71321/tg620c27 · Cited by 1 · see citing works

Cytokine multimerization: when more is more and sometimes less

Rudloff, I., Christie, M., Deen, N. S., Ellisdon, A. M., Nold‐Petry, C. A., & Nold, M. F. (2026) · Nature reviews. Immunology · doi:10.1038/s41577-026-01290-6 · Cited by 1 · see citing works

Immunotherapy and Pain

Zhao, J., Roberts, A., Huh, Y., & Ji, R. (2023) · Springer eBooks · doi:10.1007/978-3-031-29231-6_9 · Cited by 1 · see citing works

Maintenance of chronic neuroinflammation in multiple sclerosis via interferon signaling and CD8 T cell-mediated cytotoxicityPreprint

Raza, S. A., Enose‐Akahata, Y., Blazier, A. S., Guerra, L., Beck, E., Gaitán, M. I., Ngouth, N., Drijvers, J. M., Dammer, E. B., Moodley, D., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.09.658729 · Cited by 1 · see citing works

Genetically engineered biological drugs in psoriasis treatment in the COVID-19 pandemic

Svechnikova, E. V. S., Marshani, Z. B. M., Fomin, K. A. F., & Evdokimov, E. Y. E. (2021) · Russian Journal of Clinical Dermatology and Venereology · doi:10.17116/klinderma20212005195

The role of neuroimmune interactions in musculoskeletal pain

Schaible, H., Ebersberger, A., Natura, G., & Vázquez, E. (2022) · e-Neuroforum · doi:10.1515/nf-2022-0001

Vpr protein regulates expression of cytokines associated with apopotsisPreprint

Xu, Z., Gao, J.-S., Wu, Z., Zhou, H., Chen, Z., He, Y., & peng, F. (2024) · Research Square · doi:10.21203/rs.3.rs-3875163/v1

Why Anti– IL ‐17 Therapy Fails: The Role of Autonomous IL ‐ 17R Signaling in Autoimmune Inflammation

Ryser, F. S., Iype, J. M., & Christ, L. (2025) · Allergy · doi:10.1111/all.16487

ОСОБЕННОСТИ T-ХЕЛПЕРНОГО ИММУННОГО ОТВЕТА У ДЕТЕЙ РАННЕГО ВОЗРАСТА С ВРОЖДЕННЫМИ РАСЩЕЛИНАМИ ГУБЫ И НЕБА ПРИ ОСТРОЙ ПНЕВМОНИИ

Алиев, А., Sayfutdinovich, K. Z., & Ахрорхонов, Р. (2025) · Международный журнал научной педиатрии · doi:10.56121/2181-2926-2025-4-1-837-842

The emerging role of IL-17A across different types of radiation-induced normal tissue injuries

Wang, Z., Laugsand, J.-B., & Cui, G. (2025) · Therapeutic Advances in Medical Oncology · doi:10.1177/17588359251389745

Additional file 1 of IL-17-related signature genes linked to human necrotizing enterocolitis

Tremblay, É., Ferretti, E., Babakissa, C., Burghardt, K. M., Levy, E. H., & Beaulieu, J. (2021) · Figshare · doi:10.6084/m9.figshare.14168542

Nano-immunotherapy for the management of COPD

Alawneh, A., Hamzat, Y., Alzoubi, L., Alqudah, A., & Aljabali, A. A. A. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-43946-9.00006-9

Evaluation of peripheral blood gene expression in Jordanian patients with psoriasis

Alajarmeh, T., Fararjeh, A., & Alhawamdeh, M. (2025) · Egyptian Journal of Basic and Applied Sciences · doi:10.1080/2314808x.2026.2654910

PRP-Derived Exosomes Synergize with Luteolin to Protect Chondrocytes from IL-1β Injury by Targeting PERK-Mediated ER StressPreprint

Ouyang, B., Dou, C., Zhou, C., Su, D., & Yang, J. (2026) · Research Square · doi:10.21203/rs.3.rs-9307462/v1

Targeting the IL-6/IL-17 amplifier loop in fibroblasts: insights from chronic antibody-mediated rejection in kidney transplant patients

Singh, M. K., Rai, M. K., Singh, H., Gupta, V., & Prasad, N. (2026) · The Journal of Immunology · doi:10.1093/jimmun/vkag057

Autoimmune disease patients with comorbid cancer exhibit prominent immunometabolic crosstalk

Jiang, X., He, Y., Liang, N., Shen, X., Zhou, Z., Yang, D., Chen, J., Xu, J., Wang, M., Gong, Y., et al. (2026) · Science China Life Sciences · doi:10.1007/s11427-026-3465-2

The IL23/Th17 Pathway as a Therapeutic Target in Chronic Inflammatory Diseases

Toussirot, É. (2012) · Inflammation & Allergy - Drug Targets · doi:10.2174/187152812800392805 · Cited by 191 · see citing works

Targeting the IL-17/IL-23 Axis in Chronic Inflammatory Immune-Mediated Diseases

Tsoukas, A., Goodyear, C. S., & McInnes, I. B. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397933-9.00028-x · Cited by 1 · see citing works

Targeting IL-17 and TH17 cells in chronic inflammation

Miossec, P., & Kolls, J. K. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3794 · Cited by 1,414 · see citing works

IL-17 in Chronic Inflammation: From Discovery to Targeting

Beringer, A., Noack, M., & Miossec, P. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.01.001 · Cited by 404 · see citing works

The IL-23/IL-17 axis in inflammation

Iwakura, Y. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28508 · Cited by 1,046 · see citing works