The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Pathogenesis of bone and cartilage destruction in rheumatoid arthritis
Abstract
Proinflammatory cytokines, such as interleukin-1 (IL-1) and tumour necrosis factor alpha (TNFalpha), have been implicated in the dysregulation of bone and cartilage remodelling characteristic of rheumatoid arthritis (RA). With respect to bone remodelling, both of these cytokines have been shown to up-regulate the production of the receptor activator of nuclear factor-kappaB ligand, which acts to enhance osteoclastic bone resorption. TNFalpha stimulates differentiation of osteoclast progenitors into mature osteoclasts and IL-1 acts directly on osteoclasts to increase the bone-resorbing capacity of these cells. IL-1 and TNFalpha also adversely affect cartilage remodelling, although IL-1 is more potent on a molar basis. This cytokine not only increases production of factors that stimulate cartilage matrix degradation, but also inhibits the synthesis of type II collagen and proteoglycans. Enhanced understanding of the mechanisms underlying the processes of joint destruction will allow more selective and specific application of therapeutic agents that target these proinflammatory cytokines and, thus, more effective management of patients with RA and other inflammatory disorders.
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Cited by
Yamashita, T., Yao, Z., Li, F., Zhang, Q., Badell, I. R., Schwarz, E. M., Takeshita, S., Wagner, E. F., Noda, M., Matsuo, K., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610701200 · Cited by 408
Roodman, G. D., & Windle, J. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24281 · Cited by 340
The Potential of Adiponectin in Driving Arthritis
Ehling, A., Schäffler, A., Herfarth, H., Tarner, I. H., Anders, S., Distler, O., Paul, G., Distler, J., Gay, S., Schölmerich, J., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.7.4468 · Cited by 278
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Gerami, M. H., Khorram, R., Rasoolzadegan, S., Mardpour, S., Nakhaei, P., Hashemi, S., Al-Naqeeb, B. Z. T., Aminian, A., & Samimi, S. (2023) · European Journal of Medical Research · doi:10.1186/s40001-023-01034-5 · Cited by 27
Retracted
Metadata
- Authors
- Goldring, S. R.
- Venue
- Rheumatology
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-05-01
- Volume
- 42
- Issue
- 90002
- Pages
- 11ii-16
- ISSN
- 0263-7103 (ISSN-L)
- 1460-2172
- OpenAlex
- W2124007067
- Cited by
- 286
- References
- 46
- FWCI
- 11.31
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
