The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
The Potential of Adiponectin in Driving Arthritis
Open accessAbstract
Articular adipose tissue is a ubiquitous component of human joints, but its local functions are largely unknown. Because recent studies revealed several links between adipose tissue, adipocytokines, and arthritis, we investigated the expression of the adipocytokine adiponectin and its functional role in articular adipose tissue and synovium of patients with different arthritides. In contrast to its protective role in endocrinological and vascular diseases, adiponectin was found to be involved in key pathways of inflammation and matrix degradation in the human joint. The effects of adiponectin in human synovial fibroblasts appear to be highly selective by inducing only two of the main mediators of rheumatoid arthritis pathophysiology, IL-6 and matrix metalloproteinase-1, via the p38 MAPK pathway. Owing to the observation that these effects could be inhibited by different TNF-α inhibitors, adipocytokines such as adiponectin may also be key targets for therapeutic strategies in inflammatory joint diseases. In summary, articular adipose tissue and adipocytokines cannot be regarded as innocent bystanders any more in chronic inflammatory diseases such as arthritis.
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Cites
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Cited by
Emery, P., Keystone, E., Tony, H. P., Cantagrel, A., van Vollenhoven, R., Sanchez, A., Alecock, E., Lee, J., & Kremer, J. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2008.092932 · Cited by 1,104
p38MAPK: stress responses from molecular mechanisms to therapeutics
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Adipokines as emerging mediators of immune response and inflammation
Lago, F., Dieguez, C., Gómez-Reino, J., & Gualillo, O. (2007) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0674 · Cited by 567
Gioia, C., Lucchino, B., Tarsitano, M. G., Iannuccelli, C., & Di Franco, M. (2020) · Nutrients · doi:10.3390/nu12051456 · Cited by 292
Resistin in rheumatoid arthritis synovial tissue, synovial fluid and serum
Šenolt, L., Housa, D., Vernerová, Z., Jirásek, T., Svobodová, R., Veigl, D., Anderlová, K., Müller-Ladner, U., Pavelka, K., & Haluzík, M. (2007) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2006.054734 · Cited by 265
Metadata
- Authors
- Ehling, A., Schäffler, A., Herfarth, H., Tarner, I. H., Anders, S., Distler, O., Paul, G., Distler, J., Gay, S., Schölmerich, J., Neumann, E., & Müller-Ladner, U.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-04-01
- Volume
- 176
- Issue
- 7
- Pages
- 4468-4478
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1494472252
- Cited by
- 278
- References
- 72
- FWCI
- 14.15
- Type
- journal article
- Language
- en
- Open access
- green
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- Ehling, A., Schäffler, A., Herfarth, H., Tarner, I. H., Anders, S., Distler, O., Paul, G., Distler, J., Gay, S., Schölmerich, J., Neumann, E., & Müller-Ladner, U. (2006). The Potential of Adiponectin in Driving Arthritis. The Journal of Immunology. https://doi.org/10.4049/jimmunol.176.7.4468
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
