The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Towards a pro-inflammatory and immunomodulatory emerging role of leptin
Open accessAbstract
Leptin is a 16 kDa adipocyte-secreted hormone that regulates weight centrally and links nutritional status with neuroendocrine and immune function. Since its cloning in 1994, leptin's role in regulating immune and inflammatory response has become increasingly evident. Actually, the increase of leptin production that occurs during infection and inflammation strongly suggests that leptin is a part of the cytokines loop which governs the inflammatory-immune response and the host defence mechanism. Indeed, leptin stimulates the production of pro-inflammatory cytokines from cultured monocytes and enhances the production of Th1 type cytokines from stimulated lymphocytes. Several studies have implicated leptin in the pathogenesis of autoimmune inflammatory conditions such as type 1 diabetes, rheumatoid arthritis and chronic bowel disease. Obesity is characterized by elevated circulating leptin levels which might contribute significantly to the so called low-grade systemic inflammation, making obese individuals more susceptible to the increased risk of developing cardiovascular diseases, type II diabetes or inflammatory articular degenerative disease such as osteorathritis (OA). As a matter of fact, a key role for leptin in OA has been recently demonstrated since leptin exhibits, in synergy with other pro-inflammatory cytokines, a detrimental effect on articular cartilage cells by promoting nitric oxide synthesis. This review will focus prevalently on the complex relationships existing among leptin, inflammatory response and immunity, trying to provide surprising insights into leptin's role and to discuss challenges and prospects for the future.
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Cites
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BackgroundActivation of Downstream Signals by the Long Form of the Leptin Receptor
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Cited by
Obesity and weight management in the elderly
Han, T. S., Tajar, A., & Lean, M. E. J. (2011) · British Medical Bulletin · doi:10.1093/bmb/ldr002 · Cited by 327
Inflammatory Process in Type 2 Diabetes: The Role of Cytokines
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Roy, D., & Tedeschi, A. (2021) · Cells · doi:10.3390/cells10051078 · Cited by 68
Song, N.-Y., Lee, Y.-H., Na, H.-K., Baek, J.-H., & Surh, Y.-J. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.02.001 · Cited by 36
Metadata
- Authors
- Otero, M., Lago, R., Gomez, R., Dieguez, C., Lago, F., Gómez-Reino, J., & Gualillo, O.
- Venue
- Rheumatology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-05-23
- Volume
- 45
- Issue
- 8
- Pages
- 944-950
- ISSN
- 1462-0324 (ISSN-L)
- 1462-0332
- OpenAlex
- W2170273506
- Cited by
- 260
- References
- 10
- FWCI
- 14.83
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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