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Cited by 31Rheumatoid Arthritis Research and TherapiesAdrenal Hormones and DisordersHormonal Regulation and Hypertension

The 11 -hydroxysteroid dehydrogenase enzymes--arbiters of the effects of glucocorticoids in synovium and bone

Raza, K., Hardy, R., Cooper, M. S.·2010·Rheumatology
DOI 10.1093/rheumatology/keq212
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Abstract

Ever since the first use of cortisone, glucocorticoids have had a controversial role in the treatment of RA. There has been equally controversial research into the possible involvement of endogenous glucocorticoids, and their secretion via the hypothalamic-pituitary-adrenal (HPA) axis, in the development and persistence of inflammatory arthritis. Recently, our understanding of how glucocorticoids act has expanded substantially with the characterization of glucocorticoid-metabolizing enzymes that regulate glucocorticoid action at tissue level. These enzymes, the 11β-hydroxysteroid dehydrogenases, interconvert biologically inactive glucocorticoids such as cortisone and prednisone with their active counterparts, cortisol (hydrocortisone) and prednisolone. Without these enzymes, cortisone and prednisone would be therapeutically useless. Furthermore, in normal individuals, the activities of these enzymes influence the function of other components of the HPA axis. These enzymes are expressed in human synovial tissue and bone and have been implicated in the control of synovial inflammation, the development of periarticular bone loss and the sensitivity of bone to therapeutic glucocorticoids. This article reviews recent findings in this area that highlight the role of these enzymes in rheumatic diseases.

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  • The equilibrium between 11βHSD1 and 11βHSD2 expression in skin together with sympathetic nerve density can maintain immunological homeostasis.

    “The equilibrium between 11βHSD1 and 11βHSD2 expression in the skin together with sympathetic nerves density can maintain immunological homeostasis [1, 64, 150].”

    From Steroidogenesis in the skin: Implications for local immune functions (2013) · cites this paper as [150]

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Authors
Raza, K., Hardy, R., & Cooper, M. S.
Affiliations
University of Birmingham (GB)
ORCID
Venue
Rheumatology
Publisher
Oxford University Press (OUP)
Published
2010-07-15
Volume
49
Issue
11
Pages
2016-2023
ISSN
  • 1462-0324 (ISSN-L)
  • 1462-0332
DOI
10.1093/rheumatology/keq212
OpenAlex
W2157615890
Cited by
31
References
42
Citations by year
2022: 1 · 2021: 1 · 2020: 3 · 2018: 2 · 2016: 1 · 2015: 3 · 2014: 5 · 2013: 3 · 2012: 5
FWCI
0.64
Type
journal article
Language
en
Open access
closed
Locations
  • Lara D. Veeken (publishedVersion)
  • PubMed (publishedVersion)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Funders
Versus Arthritis (17730, 18081)
Topics
  • Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Keywords
11β-hydroxysteroid dehydrogenase, glucocorticoid metabolism, rheumatoid arthritis, synovium, bone, hypothalamic-pituitary-adrenal axis, cortisone, prednisone, cortisol, prednisolone, synovitis, periarticular bone loss, glucocorticoid sensitivity, glucocorticoid resistance
MeSH terms
Arthritis, Rheumatoid, Bone and Bones, Glucocorticoids, Humans, Synovial Membrane, 11-beta-Hydroxysteroid Dehydrogenases

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