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Bone marrow lesions in people with knee osteoarthritis predict progression of disease and joint replacement: a longitudinal study
Open accessAbstract
OBJECTIVES: The presence of bone marrow lesions (BMLs) has been linked to pain and progression of knee OA. The aim of this study was to determine the relationship between BMLs and longitudinal change in tibial cartilage volume and risk of knee joint replacement in subjects with knee OA. METHODS: One hundred and nine men and women with symptomatic knee OA were recruited. The same knee was imaged using MRI at baseline and ∼2 years later. Tibial cartilage volume and BMLs were measured. Knee joint replacement over 4 years was determined. RESULTS: The mean age of the subjects at baseline was 63.2 (s.d. 10.3) years. BMLs were present in 66% of the subjects. Cross-sectionally, BMLs were negatively associated with both medial (regression coefficient -121.4; 95% CI -183.8, -859.1; P<0.001) and lateral (regression coefficient -142.1; 95% CI -241.8, -42.4; P=0.01) tibial cartilage volume data. Longitudinally, for every 1-score increase in baseline BML severity (range 0-4), the annual total tibial cartilage loss was increased by 1.14% (95% CI 0.29%, 1.87%; P=0.01). The risk of knee joint replacement over 4 years increased with increasing BML score (odds ratio 1.57; 95% CI 1.04, 2.35; P=0.03). CONCLUSION: The prevalence and severity of BMLs are associated with less tibial cartilage volume and greater cartilage loss over 2 years. Moreover, severity of BMLs was positively associated with risk of knee joint replacement over 4 years. This provides further support for the importance of BMLs in identifying those with OA most likely to progress. Identifying factors that prevent or reduce the severity of BMLs may provide an important target in the prevention of disease progression and treatment of OA, and the subsequent need for arthroplasty.
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Citations
Cited by
Bone–cartilage crosstalk: a conversation for understanding osteoarthritis
Findlay, D. M., & Kuliwaba, J. S. (2016) · Bone Research · doi:10.1038/boneres.2016.28 · Cited by 283
Machine-learning-based patient-specific prediction models for knee osteoarthritis
Jamshidi, A., Pelletier, J.-P., & Martel-Pelletier, J. (2019) · Nature Reviews Rheumatology · doi:10.1038/s41584-018-0130-5 · Cited by 190
Self-citationArthritis and the role of endogenous glucocorticoids
Macfarlane, E., Seibel, M. J., & Zhou, H. (2020) · Bone Research · doi:10.1038/s41413-020-00112-2 · Cited by 64
Shabestari, M., Kise, N. J., Landin, M. A., Sesseng, S., Hellund, J. C., Reseland, J. E., Eriksen, E. F., & Haugen, I. K. (2018) · Bone & Joint Research · doi:10.1302/2046-3758.76.bjr-2017-0083.r3 · Cited by 11
Yu, S. P., Deveza, L. A., Kraus, V. B., Karsdal, M., Bay-Jensen, A.-C., Collins, J. E., Guermazi, A., Roemer, F. W., Ladel, C., Bhagavath, V., et al. (2024) · Arthritis Research & Therapy · doi:10.1186/s13075-023-03253-x · Cited by 7
Metadata
- Authors
- Tanamas, S. K., Wluka, A. E., Pelletier, J.-P., Pelletier, J. M., Abram, F., Berry, P. A., Wang, Y., Jones, G., & Cicuttini, F. M.
- Venue
- Rheumatology
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-09-07
- Volume
- 49
- Issue
- 12
- Pages
- 2413-2419
- ISSN
- 1462-0324 (ISSN-L)
- 1462-0332
- OpenAlex
- W2162085535
- Cited by
- 225
- References
- 0
- FWCI
- 7.83
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Tanamas, S. K., Wluka, A. E., Pelletier, J.-P., Pelletier, J. M., Abram, F., Berry, P. A., Wang, Y., Jones, G., & Cicuttini, F. M. (2010). Bone marrow lesions in people with knee osteoarthritis predict progression of disease and joint replacement: a longitudinal study. Rheumatology. https://doi.org/10.1093/rheumatology/keq286
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