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Enhanced angiogenesis and increased bone turnover characterize bone marrow lesions in osteoarthritis at the base of the thumb
Open accessAbstract
Objectives: Little is known about tissue changes underlying bone marrow lesions (BMLs) in non-weight-bearing joints with osteoarthritis (OA). Our aim was to characterize BMLs in OA of the hand using dynamic histomorphometry. We therefore quantified bone turnover and angiogenesis in subchondral bone at the base of the thumb, and compared the findings with control bone from hip OA. Methods: Patients with OA at the base of the thumb, or the hip, underwent preoperative MRI to assess BMLs, and tetracycline labelling to determine bone turnover. Three groups were compared: trapezium bones removed by trapeziectomy from patients with thumb base OA (n = 20); femoral heads with (n = 24); and those without (n = 9) BMLs obtained from patients with hip OA who underwent total hip arthroplasty. Results: All trapezium bones demonstrated MRI-defined BMLs. Compared with femoral heads without BMLs, the trapezia demonstrated significantly higher bone turnover (mean sd 0.2 (0.1) versus 0.01 (0.01) µm 3/µm 2/day), mineralizing surface (18.5% (13.1) versus 1.4% (1.3)) and vascularity (5.2% (1.1) versus 1.2% (0.6)). Femoral heads with BMLs exhibited higher bone turnover (0.3 (0.2) versus 0.2 (0.1) µm 3/µm 2/day), a higher mineralization rate (26.6% (10.6) versus 18.6% (11.9)) and greater trabecular thickness (301.3 µm (108) versus 163.6 µm (24.8)) than the trapezia. Conclusion: Bone turnover and angiogenesis were enhanced in BMLs of both the thumb base and hip OA, of which the latter exhibited the highest bone turnover. Thus, the increase in bone turnover in weight-bearing joints like the hip may be more pronounced than less mechanically loaded osteoarthritic joints demonstrating BMLs. The histological changes observed may explain the water signal from BMLs on MRI. Cite this article: M. Shabestari, N. J. Kise, M. A. Landin, S. Sesseng, J. C. Hellund, J. E. Reseland, E. F. Eriksen, I. K. Haugen. Enhanced angiogenesis and increased bone turnover characterize bone marrow lesions in osteoarthritis at the base of the thumb. Bone Joint Res 2018;7:406–413. DOI: 10.1302/2046-3758.76.BJR-2017-0083.R3.
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Fibroblasts are important both for the deposition and remodeling of extracellular matrix and for the recruitment of growth factors and cytokines in the fracture site, where they trigger healing processes such as the formation of new vessels.
“In fact, it is well known that fibroblasts are important both for the deposition and remodeling of extracellular matrix and for the recruitment of growth factors and cytokines in the fracture site, where they trigger healing processes such as the formation of new vessels [60].”
From Skeletal System Biology and Smoke Damage: From Basic Science to Medical Clinic (2021) · cites this paper as [60]
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Metadata
- Authors
- Shabestari, M., Kise, N. J., Landin, M. A., Sesseng, S., Hellund, J. C., Reseland, J. E., Eriksen, E. F., & Haugen, I. K.
- Affiliations
- University of Oslo (NO)
- Martina Hansens Hospital (NO)
- Diakonhjemmet Hospital (NO)
- Oslo University Hospital (NO)
- Corresponding author
- Shabestari, M.
- Venue
- Bone & Joint Research
- Published
- 2018-06
- Volume
- 7
- Issue
- 6
- Pages
- 406-413
- ISSN
- 2046-3758 (ISSN-L)
- PMC
- PMC6035357
- OpenAlex
- W2809615247
- Cited by
- 11
- References
- 45
- Citations by year
- 2024: 4 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 1
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Bone and Joint Research (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- NORA - Norwegian Open Research Archives (submittedVersion, cc-by-nc)
- Funders
- EkstraStiftelsen Helse og Rehabilitering (Stiftelsen Dam)
- Topics
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone and Joint Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Keywords
- bone marrow lesions, osteoarthritis, thumb base osteoarthritis, hand osteoarthritis, bone turnover, angiogenesis, subchondral bone, tetracycline labeling, histomorphometry, trapezium, femoral head, hip osteoarthritis, trabecular bone, mechanical loading, trapeziectomy
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