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Cited by 301

The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.

Update on the Clinical Efficacy and Side Effects of Clozapine

Open access
Safferman, A., Lieberman, J. A., Kane, J. M., Szymanski, S., Kinon, B.·1991·Schizophrenia Bulletin
DOI 10.1093/schbul/17.2.247
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Abstract

Clozapine (CLOZ) is an atypical antipsychotic drug being used with increasing frequency throughout the world and has recently been commercially marketed in the United States. Its unique properties make it a promising but challenging drug to use in the treatment of schizophrenia. In order to use CLOZ most effectively and efficiently, clinicians must be aware of its potential benefits and risks. This report is a review and critical evaluation of current knowledge regarding the clinical efficacy and side effects of CLOZ. Although CLOZ has proven to be effective in some treatment-refractory schizophrenic patients and to produce relatively few extrapyramidal side effects compared to classical neuroleptic drugs, several issues require further investigation including what defines neuroleptic intolerance, the optimal dose range, and the appropriate duration of a CLOZ treatment trial. Similarly, studies are needed to determine what role CLOZ should have in the treatment of patients with predominantly negative symptoms and those patients who are only partially responsive to standard neuroleptics. In addition, important questions remain as to what other conditions might be indications for CLOZ, for example, schizoaffective disorder, affective psychoses, and idiopathic Parkinson's disease.

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Metadata

Authors
Safferman, A., Lieberman, J. A., Kane, J. M., Szymanski, S., & Kinon, B.
Venue
Schizophrenia Bulletin
Publisher
Oxford University Press (OUP)
Published
1991-01-01
Volume
17
Issue
2
Pages
247-261
ISSN
  • 0586-7614 (ISSN-L)
  • 1745-1701
DOI
10.1093/schbul/17.2.247
OpenAlex
W2036121762
Cited by
301
References
55
FWCI
16.69
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Update on the Clinical Efficacy and Side Effects of Clozapine. https://app.cochat.ai/papers/10.1093/schbul/17.2.247
The paper
Safferman, A., Lieberman, J. A., Kane, J. M., Szymanski, S., & Kinon, B. (1991). Update on the Clinical Efficacy and Side Effects of Clozapine. Schizophrenia Bulletin. https://doi.org/10.1093/schbul/17.2.247

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.