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Subjective Response to Neuroleptics in Schizophrenia
Abstract
Subjective response to neuroleptics in patients with schizophrenia is reviewed in terms of its validity and measurement. Evidence is presented to support a correlation between altered subjective state on neuroleptics, and therapeutic outcome and medication compliance. Factors that have been implicated in the genesis of such altered subjective states include demographics, psychiatric characteristics, type and dose of neuroleptic, extrapyramidal symptoms (particularly akathisia), depressive states, and patients' values and attitudes toward health and illness. Factors that may contribute to lack of interest in researching subjective experiences of schizophrenia patients on medications are reviewed, and methodological improvements in study design are proposed to enhance our understanding of this phenomenon. Such understanding may help us to better appreciate the many factors that contribute to variability of responses to neuroleptic therapy in patients with schizophrenia and also help us to develop more effective treatment strategies.
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Cites
The Brief Psychiatric Rating Scale.
Overall, J. E., & Gorham, D. R. (1962) · Psychological Reports · doi:10.2466/pr0.1962.10.3.799 · Cited by 11,090
Lyness, W. H., Friedle, N. M., & Moore, K. E. (1979) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(79)90040-6 · Cited by 457
Cited by
From dopamine to salience to psychosis—Linking biology, pharmacology and phenomenology of psychosis
Kapur, S., Mizrahi, R., & Li, M. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2005.01.003 · Cited by 512
VORUGANTI, L., HESLEGRAVE, R., AWAD, A. G., & SEEMAN, M. V. (1998) · Psychological Medicine · doi:10.1017/s0033291797005874 · Cited by 260
Self-citationDo Patients With Schizophrenia Wish to Be Involved in Decisions About Their Medical Treatment?
Hamann, J., Cohen, R., Leucht, S., Busch, R., & Kissling, W. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.12.2382 · Cited by 254
Attitudes towards pharmacotherapy in late-life bipolar disorder
Rej, S., Schuurmans, J., Elie, D., Stek, M. L., Shulman, K., & Dols, A. (2016) · International Psychogeriatrics · doi:10.1017/s1041610215002380 · Cited by 23
Metadata
- Authors
- Awad, A. G.
- Venue
- Schizophrenia Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 1993-01-01
- Volume
- 19
- Issue
- 3
- Pages
- 609-618
- ISSN
- 0586-7614 (ISSN-L)
- 1745-1701
- OpenAlex
- W2110091980
- Cited by
- 276
- References
- 2
- FWCI
- 4.32
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
