Cited by 457Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchNeural and Behavioral Psychology Studies

Destruction of dopaminergic nerve terminals in nucleus accumbens: Effect on d-amphetamine self-administration

Lyness, W.H., Friedle, N.M., Moore, K.E.·1979·Pharmacology Biochemistry and Behavior

Abstract

Control rats initiate self-administration of d-amphetamine and achieve stable injection rates within 7-10 days. Rats in which dopamine nerve terminals in nucleus accumbens were destroyed by bilateral microinjections of 6-hydroxydopamine (6-OHDA) did not initiate self-administration of d-amphetamine when tested for as long as 19 days. In rats previously trained to self-administer d-amphetamine, 6-OHDA injections into nucleus accumbens abolished d-amphetamine self-administration. These results suggest that dopaminergic nerve terminals in nucleus accumbens are necessary for both the acquisition and maintenance of d-amphetamine self-administration.

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Crossref · 10.1016/0091-3057(79)90040-6

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Authors
Lyness, W. H., Friedle, N. M., & Moore, K. E.
Affiliations
Michigan State University (US)
Venue
Pharmacology Biochemistry and Behavior
Publisher
Elsevier BV
Published
1979-11
Volume
11
Issue
5
Pages
553-556
ISSN
0091-3057 (ISSN-L)
OpenAlex
W2010569958
Cited by
457
References
15
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2021: 4 · 2020: 9 · 2019: 3 · 2018: 6 · 2016: 8 · 2015: 3 · 2014: 8 · 2013: 7 · 2012: 8
FWCI
5.83
Type
journal article
Language
en
Open access
closed
Locations
  • Pharmacology Biochemistry and Behavior (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
nucleus accumbens, dopaminergic terminals, 6-hydroxydopamine, dopamine depletion, amphetamine self-administration, self-administration, reward
MeSH terms
Animals, Conditioning, Operant, Dextroamphetamine, Dopamine, Hydroxydopamines, Male, Nerve Endings, Nucleus Accumbens, Self Administration, Septal Nuclei, Rats

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