Destruction of dopaminergic nerve terminals in nucleus accumbens: Effect on d-amphetamine self-administration
Abstract
Control rats initiate self-administration of d-amphetamine and achieve stable injection rates within 7-10 days. Rats in which dopamine nerve terminals in nucleus accumbens were destroyed by bilateral microinjections of 6-hydroxydopamine (6-OHDA) did not initiate self-administration of d-amphetamine when tested for as long as 19 days. In rats previously trained to self-administer d-amphetamine, 6-OHDA injections into nucleus accumbens abolished d-amphetamine self-administration. These results suggest that dopaminergic nerve terminals in nucleus accumbens are necessary for both the acquisition and maintenance of d-amphetamine self-administration.
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Lesion or inactivation of the mesolimbic DA system in the VTA or NAc decreases cocaine, amphetamine, heroin, and nicotine self-administration in rats.
“In addition, lesion or inactivation of the mesolimbic DA system in the VTA [137,138] or in the NAc [139-143] decreases cocaine, amphetamine, heroin, and nicotine self-administration in rats.”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [140]
Depletion of dopamine in the nucleus accumbens induced by local 6-hydroxydopamine injections severely attenuates the rewarding effects of cocaine or amphetamine, as assessed by instrumental responses or conditioned place preference.
“Depletion of dopamine in the nucleus accumbens induced by local 6-hydroxydopamine (6-OHDA) injections severely attenuates the rewarding effects of cocaine or amphetamine, as assessed by instrumental responses”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Lyness et al., 1979
Cites
A stereotaxic atlas of the rat brain
Pellegrino, L. J., & Cushman, A. J. (1967) · Plenum Press eBooks · Cited by 4,688 · see citing works
Kelly, P. H., Seviour, P. W., & Iversen, S. D. (1975) · Brain Research · doi:10.1016/0006-8993(75)90233-4 · Cited by 1,740 · see citing works
Catecholamine theories of reward: A critical review
Wise, R. A. (1978) · Brain Research · doi:10.1016/0006-8993(78)90253-6 · Cited by 769 · see citing works
On the role of ascending catecholaminergic systems in intravenous self-administration of cocaine
Roberts, D. C. S., Corcoran, M. E., & Fibiger, H. C. (1977) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(77)90084-3 · Cited by 728 · see citing works
Experimental Morphine Addiction: Method for Automatic Intravenous Injections in Unrestrained Rats
Weeks, J. R. (1962) · Science · doi:10.1126/science.138.3537.143 · Cited by 658 · see citing works
Effects of chemical stimulation of the mesolimbic dopamine system upon locomotor activity
Pijnenburg, A. J. J., Honig, W. M. M., van Rossum, J. M., & van Rossum, J. M. (1976) · European Journal of Pharmacology · doi:10.1016/0014-2999(76)90299-5 · Cited by 563 · see citing works
Yokel, R. A., & Wise, R. A. (1975) · Science · doi:10.1126/science.1114313 · Cited by 545 · see citing works
Attenuation of intravenous amphetamine reinforcement by central dopamine blockade in rats
Yokel, R. A., & Wise, R. A. (1976) · Psychopharmacology · doi:10.1007/bf00496868 · Cited by 369 · see citing works
Both Positive Reinforcement and Conditioned Aversion from Amphetamine and from Apomorphine in Rats
Wise, R. A., Yokel, R. A., & de Wit, H. (1976) · Science · doi:10.1126/science.1257748 · Cited by 312 · see citing works
Self-administration of d-amphetamine by rats
Pickens, R. W., & Harris, W. C. (1968) · Psychopharmacology · doi:10.1007/bf00401545 · Cited by 296 · see citing works
Amphetamine-type reinforcement by dopaminergic agonists in the rat
Yokel, R. A., & Wise, R. A. (1978) · Psychopharmacology · doi:10.1007/bf00427393 · Cited by 181 · see citing works
Effect of haloperidol on (+)-amphetamine self-administration
Davis, W. M., & Smith, S. G. (1975) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1975.tb09502.x · Cited by 95 · see citing works
Effects of drugs on regional brain concentrations of dopamine and dihydroxyphenylacetic acid.
Umezu, K., & Moore, K. E. (1979) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)31522-3 · Cited by 87 · see citing works
Self-citationThe pneumatic syringe: A simple apparatus for self-administration of drugs by rats
Weeks, J. R. (1977) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(77)90254-4 · Cited by 30 · see citing works
Interactions of 5-hydroxytryptamine and gamma-aminobutyric acid with dopamine.
Cj, P., Rw, H., & Carter, C. J. (1978) · PubMed · Cited by 26 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Dopamine, learning and motivation.
Wise, R. A. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1406 · Cited by 3,379 · see citing works
A psychomotor stimulant theory of addiction.
Wise, R. A., & Bozarth, M. A. (1987) · Psychological Review · doi:10.1037/0033-295x.94.4.469 · Cited by 2,747 · see citing works
A neuropsychological theory of positive affect and its influence on cognition.
Ashby, F. G., Isen, A. M., & Turken, A. U. (1999) · Psychological Review · doi:10.1037/0033-295x.106.3.529 · Cited by 2,270 · see citing works
Cellular and molecular mechanisms of drug dependence
Koob, G. F., & Bloom, F. E. (1988) · Science · doi:10.1126/science.2903550 · Cited by 2,070 · see citing works
Drugs of abuse: anatomy, pharmacology and function of reward pathways
Koob, G. F. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90060-j · Cited by 2,070 · see citing works
Depue, R. A., & Collins, P. F. (1999) · Behavioral and Brain Sciences · doi:10.1017/s0140525x99002046 · Cited by 2,046 · see citing works
Ikemoto, S. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.05.004 · Cited by 1,477 · see citing works
Ikemoto, S., & Panksepp, J. (1999) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00023-5 · Cited by 1,450 · see citing works
Nucleus accumbens shell and core dopamine: differential role in behavior and addiction
Di Chiara, G. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00286-3 · Cited by 996 · see citing works
Addictive Drugs and Brain Stimulation Reward
Wise, R. A. (1996) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.19.030196.001535 · Cited by 792 · see citing works
Drug-activation of brain reward pathways
Wise, R. A. (1998) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(98)00063-5 · Cited by 684 · see citing works
Solanto, M. V. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00175-7 · Cited by 677 · see citing works
Involvement of the amygdala in stimulus-reward associations: interaction with the ventral striatum
Cador, M., Robbins, T. W., & Everitt, B. J. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90354-0 · Cited by 652 · see citing works
Pettit, H. O., Ettenberg, A., Bloom, F. E., & Koob, G. F. (1984) · Psychopharmacology · doi:10.1007/bf00427441 · Cited by 651 · see citing works
Hernandez, L., & Hoebel, B. G. (1988) · Life Sciences · doi:10.1016/0024-3205(88)90036-7 · Cited by 627 · see citing works
McBride, W. J., Murphy, J. M., & Ikemoto, S. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00022-4 · Cited by 574 · see citing works
Vezina, P. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.11.001 · Cited by 515 · see citing works
Brain reward circuitry beyond the mesolimbic dopamine system: a neurobiological theory
Ikemoto, S. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.02.001 · Cited by 454 · see citing works
Limbic-striatal interactions in reward-related processes
Robbins, T. W., Cador, M., Taylor, J. R., & Everitt, B. J. (1989) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(89)80025-9 · Cited by 458 · see citing works
Roberts, D. C. S., & Koob, G. F. (1982) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(82)90469-5 · Cited by 448 · see citing works
Benwell, M. E. M., & Balfour, D. J. K. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb09067.x · Cited by 426 · see citing works
The neurocircuitry of addiction: an overview
Feltenstein, M. W., & See, R. E. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.51 · Cited by 421 · see citing works
Self-injection of amphetamine directly into the brain
Hoebel, B. G., Monaco, A. P., Hernandez, L., Aulisi, E. F., Stanley, B. G., & Lenard, L. (1983) · Psychopharmacology · doi:10.1007/bf00429012 · Cited by 367 · see citing works
Rewarding Actions of Phencyclidine and Related Drugs in Nucleus Accumbens Shell and Frontal Cortex
Carlezon, & Wise, R. A. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-09-03112.1996 · Cited by 327 · see citing works
Dichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299 · see citing works
Addictive drugs as reinforcers: multiple partial actions on memory systems
WHITE, N. M. (1996) · Addiction · doi:10.1111/j.1360-0443.1996.tb03586.x · Cited by 439 · see citing works
Jones, G. H., Marsden, C. A., & Robbins, T. W. (1990) · Psychopharmacology · doi:10.1007/bf02244105 · Cited by 232 · see citing works
The ventral pallidum plays a role in mediating cocaine and heroin self-administration in the rat
Hubner, C. B., & Koob, G. F. (1990) · Brain Research · doi:10.1016/0006-8993(90)91112-t · Cited by 218 · see citing works
Basal ganglia circuit loops, dopamine and motivation: a review and enquiry
Ikemoto, S., Yang, C., & Tan, A. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.04.018 · Cited by 226 · see citing works
“Selective reduction of DA transmission with intra-VStr injections of DA receptor antagonists or 6-OH-DA lesions of VStr DA terminals also reduces or diminishes self-administration of these drugs, depending on the dose [48–52].”
Dopamine signaling in the nucleus accumbens of animals self-administering drugs of abuse
Willuhn, I., Wanat, M. J., Clark, J. J., & Phillips, P. E. M. (2010) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2009_27 · Cited by 193 · see citing works
The role of dopamine in intracranial self-stimulation of the ventral tegmental area
Fibiger, H., LePiane, F., Jakubovic, A., & Phillips, A. (1987) · The Journal of Neuroscience · doi:10.1523/jneurosci.07-12-03888.1987 · Cited by 189 · see citing works
Anderson, S. M., Bari, A. A., & Pierce, R. C. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1298-5 · Cited by 178 · see citing works
Experimental approach to individual vulnerability to psychostimulant addiction
Deminiere, J. M., Piazza, P. V., Le Moal, M., & Simon, H. (1989) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(89)80023-5 · Cited by 177 · see citing works
Habit-forming actions of nomifensine in nucleus accumbens
Carlezon, W. A., Devine, D. P., & Wise, R. A. (1995) · Psychopharmacology · doi:10.1007/bf02246095 · Cited by 170 · see citing works
Cador, M., Taylor, J. R., & Robbins, T. W. (1991) · Psychopharmacology · doi:10.1007/bf02246039 · Cited by 158 · see citing works
Smelling sounds: Olfactory-auditory sensory convergence in the olfactory tubercle
Wesson, D. W., & Wilson, D. A. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.6003-09.2010 · Cited by 150 · see citing works
The functional output of the mesolimbic dopamine system
KOOB, G. F., & SWERDLOW, N. R. (1988) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1988.tb42108.x · Cited by 149 · see citing works
The HR/LR model: further evidence as an animal model of sensation seeking
Blanchard, M. M., Mendelsohn, D., & Stamp, J. A. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.05.009 · Cited by 121 · see citing works
Phillips, G. D., Robbins, T. W., & Everitt, B. J. (1994) · Psychopharmacology · doi:10.1007/bf02249339 · Cited by 116 · see citing works
Mehrara, B. J., & Baum, M. J. (1990) · Psychopharmacology · doi:10.1007/bf02253728 · Cited by 112 · see citing works
The Neuronal Pathways Mediating the Behavioral and Addictive Properties of Nicotine
Balfour, D. J. K. (2009) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-540-69248-5_8 · Cited by 99 · see citing works
- Authors
- Lyness, W. H., Friedle, N. M., & Moore, K. E.
- Affiliations
- Michigan State University (US)
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 1979-11
- Volume
- 11
- Issue
- 5
- Pages
- 553-556
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W2010569958
- Cited by
- 457
- References
- 15
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2021: 4 · 2020: 9 · 2019: 3 · 2018: 6 · 2016: 8 · 2015: 3 · 2014: 8 · 2013: 7 · 2012: 8
- FWCI
- 5.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- nucleus accumbens, dopaminergic terminals, 6-hydroxydopamine, dopamine depletion, amphetamine self-administration, self-administration, reward
- MeSH terms
- Animals, Conditioning, Operant, Dextroamphetamine, Dopamine, Hydroxydopamines, Male, Nerve Endings, Nucleus Accumbens, Self Administration, Septal Nuclei, Rats
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