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Affective Dysregulation and Reality Distortion: A 10-Year Prospective Study of Their Association and Clinical Relevance
Open accessAbstract
Evidence from clinical patient populations indicates that affective dysregulation is strongly associated with reality distortion, suggesting that a process of misassignment of emotional salience may underlie this connection. To examine this in more detail without clinical confounds, affective regulation-reality distortion relationships, and their clinical relevance, were examined in a German prospective cohort community study. A cohort of 2524 adolescents and young adults aged 14-24 years at baseline was examined by experienced psychologists. Presence of psychotic experiences and (hypo)manic and depressive symptoms was assessed at 2 time points (3.5 and up to 10 years after baseline) using the Munich-Composite International Diagnostic Interview. Associations were tested between level of affective dysregulation on the one hand and incidence of psychotic experiences, persistence of these experiences, and psychotic Impairment on the other. Most psychotic experiences occurred in a context of affective dysregulation, and bidirectional dose-response was apparent with greater level of both affective dysregulation and psychotic experiences. Persistence of psychotic experiences was progressively more likely with greater level of (hypo)manic symptoms (odds ratio [OR] trend=1.51, P<.001) and depressive symptoms (OR trend=1.15, P=.012). Similarly, psychotic experiences of clinical relevance were progressively more likely to occur with greater level of affective dysregulation (depressive symptoms: OR trend=1.28, P=.002; (hypo)manic symptoms: OR trend=1.37, P=.036). Correlated genetic liabilities underlying affective and nonaffective psychotic syndromes may be expressed as correlated dimensions in the general population. Also, affective dysregulation may contribute causally to the persistence and clinical relevance of reality distortion, possibly by facilitating a mechanism of aberrant salience attribution.
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Citations
Cites
The Brief Psychiatric Rating Scale.
Overall, J. E., & Gorham, D. R. (1962) · Psychological Reports · doi:10.2466/pr0.1962.10.3.799 · Cited by 11,090
Kapur, S. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.1.13 · Cited by 2,813
Wittchen, H.-U. (1994) · Journal of Psychiatric Research · doi:10.1016/0022-3956(94)90036-1 · Cited by 2,348
van Os, J., Linscott, R. J., Myin-Germeys, I., Delespaul, P., & Krabbendam, L. (2009) · Psychological Medicine · doi:10.1017/s0033291708003814 · Cited by 2,343
Lichtenstein, P., Yip, B. H., Björk, C., Pawitan, Y., Cannon, T. D., Sullivan, P. F., & Hultman, C. M. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60072-6 · Cited by 2,125
van Os, J., & Kapur, S. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60995-8 · Cited by 1,971
A cognitive model of the positive symptoms of psychosis
GARETY, P. A., KUIPERS, E., FOWLER, D., FREEMAN, D., & BEBBINGTON, P. E. (2001) · Psychological Medicine · doi:10.1017/s0033291701003312 · Cited by 1,546 · cited 2×
“Existent psychological models of symptom formation suggest that the emotional context, and associated beliefs or appraisals, may induce bias in logical reasoning processes and, therefore, provoke reality distortion in healthy individuals.(2,15) In the psychological model described by Garety and colleagues,(1) the expe…”
Lifetime Prevalence of Psychotic and Bipolar I Disorders in a General Population
Perälä, J., Suvisaari, J., Saarni, S. I., Kuoppasalmi, K. I., Isometsä, E. T., Pirkola, S. P., Partonen, T., Tuulio‐Henriksson, A., Hintikka, J., Kieseppä, T., et al. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.1.19 · Cited by 1,523
Cannon, T. D., Cadenhead, K., Cornblatt, B., Woods, S. W., Addington, J., Walker, E., Seidman, L. J., Perkins, D., Tsuang, M., McGlashan, T., et al. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.3 · Cited by 1,269
Children's Self-Reported Psychotic Symptoms and Adult Schizophreniform Disorder
Poulton, R., Caspi, A., Moffitt, T. E., Cannon, M. D., Murray, R. M., & Harrington, H. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.11.1053 · Cited by 1,139
Research works printed but not linked: 5
- Craddock, 2007, 6, 84
- 1999, American Journal of Psychiatry, 1056, 1736
- 2009, Schizophrenia Bulletin, 35, 74
- 1998, International journal of methods in psychiatric research, 7, 619
- 1962, Psychological reports, 10, 799, 10.2466/PR0.10.3.799-812 · DOI · Paper page
Cited by
Sorted by citations
Items 101–170 of 170
Musci, R. J., Kush, J. M., Masyn, K. E., Amin‐Esmaeili, M., Susukida, R., Goulter, N., McMahon, R. J., Eddy, J. M., Ialongo, N. S., Tolan, P. H., et al. (2023) · Prevention Science · doi:10.1007/s11121-023-01581-7 · Cited by 16
Sellers, R., Adrian Wells, A., Parker, S., & Morrison, A. P. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.10.032 · Cited by 15
The Concept of Schizophrenia: From Unity to Diversity
Häfner, H. (2014) · Advances in Psychiatry · doi:10.1155/2014/929434 · Cited by 18
The difference between desistance from sexual offending and not reoffending
Cooley, B. N., & Sample, L. L. (2018) · Journal of Crime and Justice · doi:10.1080/0735648x.2018.1479286 · Cited by 14
Kırlı, U., Binbay, T., Drukker, M., van Os, J., Alptekın, K., Kayahan, B., & Elbi, H. (2019) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-018-1641-8 · Cited by 15
Schizophrenia and the Place of Egodystonic States in the Aetiology of Thought Insertion
López‐Silva, P. (2015) · Review of Philosophy and Psychology · doi:10.1007/s13164-015-0272-1 · Cited by 14
Wolthusen, R. P. F., Coombs, G., Boeke, E. A., Ehrlich, S., DeCross, S. N., Nasr, S., & Holt, D. J. (2017) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2017.06.007 · Cited by 14
The typology problem and the doxastic approach to delusions
López‐Silva, P. (2016) · Filosofia Unisinos · doi:10.4013/fsu.2016.172.15 · Cited by 12
Gioia, F., Imperato, C., Boursier, V., Franceschini, C., Schimmenti, A., & Musetti, A. (2023) · Scientific Reports · doi:10.1038/s41598-023-30531-0 · Cited by 14
Relaciones entre síntomas psicóticos subclínicos y rendimiento cognitivo en la población general
Martín-Santiago, Ó., Suazo, V., Rodríguez‐Lorenzana, A., de Azúa, S. R., Valcárcel, C., Díez, Á., Grau, A., Domínguez, C., Gallardo, R., & Molina, V. (2015) · Revista de Psiquiatría y Salud Mental · doi:10.1016/j.rpsm.2015.10.004 · Cited by 11
Taylor, H. E., Stewart, S., Dunn, G., Parker, S., Bentall, R. P., Birchwood, M. J., & Morrison, A. P. (2013) · Early Intervention in Psychiatry · doi:10.1111/eip.12064 · Cited by 11
Gong, J., Luo, Y., He, Y., Zhou, L., Zhao, L., & Liu, J. (2022) · Schizophrenia Research · doi:10.1016/j.schres.2022.02.037 · Cited by 10
Assessing and managing hallucinations in children and adolescents
Dominguez, M.-D.-G., & Garralda, M. E. (2016) · BJPsych Advances · doi:10.1192/apt.bp.115.014738 · Cited by 10
Self-citationChang, W. C., Ng, C. M., Chan, J. K. N., Lee, H. C., Chan, S. I., Chiu, S. S., Lee, E. H. M., Chan, S. K. W., Wong, M. C., Chan, K. L. P., et al. (2020) · Early Intervention in Psychiatry · doi:10.1111/eip.12992 · Cited by 10
Lindgren, M., Jonninen, M., Jokela, M. M., & Therman, S. (2018) · European Psychiatry · doi:10.1016/j.eurpsy.2018.10.004 · Cited by 11
Fekih‐Romdhane, F., Houissa, L., Loch, A. A., Cheour, M., & Hallit, S. R. (2024) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/s13034-024-00825-w · Cited by 11
Higher Depression Scores in Patients with Drug-Resistant Schizophrenia
Panov, G. (2022) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2105126 · Cited by 9
Havers, L., von Stumm, S., Cardno, A. G., Freeman, D. H., & Ronald, A. (2022) · Psychological Medicine · doi:10.1017/s0033291722002914 · Cited by 10
Abbs, B., Achalia, R. M., Adelufosi, A. O., Aktener, A. Y., Beveridge, N. J., Bhakta, S. G., Blackman, R. K., Bora, E., Byun, M. S., Cabanis, M., et al. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.07.024 · Cited by 8
Martín-Santiago, Ó., Suazo, V., Rodríguez‐Lorenzana, A., de Azúa, S. R., Valcárcel, C., Díez, Á., Grau, A., Domínguez, C., Gallardo, R., & Molina, V. (2016) · Revista de Psiquiatría y Salud Mental (English Edition) · doi:10.1016/j.rpsmen.2016.04.004 · Cited by 9
Bornheimer, L. A., Martz, M. E., Suzuki, T., Tso, I. F., Burton, C. Z., Verdugo, J. L., Grove, T. B., Heitzeg, M. M., & Taylor, S. F. (2022) · Schizophrenia Bulletin · doi:10.1093/schbul/sbac015 · Cited by 10
Gajwani, R., Wilson, N., Nelson, R., Gumley, A. I., Smith, M. R., & Minnis, H. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.943509 · Cited by 13
Nielsen, L. G., Rimvall, M. K., van Os, J., Verhulst, F. C., Rask, C. U., Skovgaard, A. M., Olsen, E. M., & Jeppesen, P. (2021) · PLoS ONE · doi:10.1371/journal.pone.0253507 · Cited by 9
Zhang, Y., Liu, J., Chen, L., Yang, T., Luo, X., Cui, X., Wu, S., He, Y., & Lu, J. (2023) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2023.106470 · Cited by 8
Austin, S. F., Hastrup, L. H., van Os, J., & Simonsen, E. H. (2023) · Schizophrenia Research · doi:10.1016/j.schres.2023.08.013 · Cited by 10
Wang, Q., Ren, H., Liu, T., & Zhang, X. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.01.208 · Cited by 7
The heritability of delusional‐like experiences
Varghese, D., Wray, N. R., Scott, J. G., Williams, G. M., Najman, J. M., & McGrath, J. J. (2012) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2012.01905.x · Cited by 7
Moriyama, T. S., Drukker, M., Gülöksüz, S., Have, M. T., de Graaf, R., van Dorsselaer, S., Günther, N., Bak, M., & van Os, J. (2020) · Psychological Medicine · doi:10.1017/s0033291720000793 · Cited by 6
Schepers, E., van Os, J., & Lousberg, R. L. (2019) · PLoS ONE · doi:10.1371/journal.pone.0211914 · Cited by 6
Kramer, I. M. A. (2015) · Research Publications (Maastricht University) · doi:10.26481/dis.20150430ik · Cited by 6
Logoń, K., Świrkosz, G., & Kowalski, K. (2024) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/186815 · Cited by 7
The modern concept of schizoaffective disorder: a narrative review
Pavlichenko, A. V., Петрова, Н. Н., & Stolyarov, A. R. (2024) · Consortium Psychiatricum · doi:10.17816/cp15513 · Cited by 7
Schizophrenia and Depression – Challenging the Paradigm of Two Separate Diseases
Häfner, H., & der Heiden, W. A. (2011) · Springer eBooks · doi:10.1007/978-94-007-0831-0_16 · Cited by 5
Schmitz, G., & Tandonnet, L. (2023) · Neuropsychiatrie de l Enfance et de l Adolescence · doi:10.1016/j.neurenf.2023.01.006 · Cited by 4
Kapfhammer, H. (2012) · Neuropsychiatrie · doi:10.1007/s40211-012-0031-9 · Cited by 4
Reward anticipation in individuals with subclinical psychotic experiences: A functional MRI approach
Michielse, S., Lange, I., Bakker, J. M., Goossens, L., Verhagen, S. J. W., Papalini, S., Wichers, M., Lieverse, R., Schruers, K. R. J., van Amelsvoort, T., et al. (2019) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2019.10.002 · Cited by 5
Baharnoori, M., Bartholomeusz, C., Boucher, A. A., Buchy, L., Chaddock, C., Chiliza, B., Föcking, M., Fornito, A., Gallego, J. A., Hori, H., et al. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.09.008 · Cited by 6
Connell, M., Scott, J. G., McGrath, J. J., Waters, F., Larøi, F., Alati, R., Najman, J. M., & Betts, K. S. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.01.079 · Cited by 4
Ristanovic, I., Pratt, D. N., Strauss, G. P., & Mittal, V. A. (2025) · Schizophrenia Bulletin · doi:10.1093/schbul/sbaf088 · Cited by 3
Early Intervention in Emerging Psychosis: State of the Art and Future Perspectives
McGorry, P. D., & Goldstone, S. D. (2016) · Key issues in mental health (Online)/Key issues in mental health (Print) · doi:10.1159/000440911 · Cited by 3
Koummati, M., Vrubļevska, J., Binder, M. D., Young, A. H., Fusar‐Poli, P., Tandon, R., Javed, A., & Fountoulakis, K. Ν. (2025) · CNS Spectrums · doi:10.1017/s1092852925000112 · Cited by 3
Ergül, C., Drukker, M., Binbay, T., Kirli, U., Elbi, H., Alptekın, K., van Os, J., 1, H.-M., & Brain (2023) · Utrecht University Repository (Utrecht University) · Cited by 3
Validity evidence of the ESQUIZO-Q-A for measuring schizotypy in young substance-using populations
González‐Roz, A., Iza-Fernández, C., Alemán‐Moussa, L., Secades‐Villa, R., García-Fernández, J., & Paíno, M. (2026) · Current Psychology · doi:10.1007/s12144-026-09257-5 · Cited by 2
The Occurrence of Positive Psychotic Experiences in an Outpatient Clinic in Flanders
Gaul, K., Loore, E. D., & West, D. V. (2017) · Journal of Child and Adolescent Behaviour · doi:10.4172/2375-4494.1000338 · Cited by 1
The role of emotional regulation difficulties in unusual sensory experiences
Gaynor, K., O’Donnell, P., Cullen, M., & Lee, J. (2023) · Psychosis · doi:10.1080/17522439.2023.2280510 · Cited by 2
Dumas, L.-É., Bonnard-Couton, V., Golse, B., & Askenazy-Gittard, F. (2021) · L Encéphale · doi:10.1016/j.encep.2021.06.010 · Cited by 3
Ergül, C., Drukker, M., Binbay, T., Kırlı, U., Elbi, H., Alptekın, K., & van Os, J. (2022) · Psychological Medicine · doi:10.1017/s0033291722000642 · Cited by 3
Fekih‐Romdhane, F., Nemr, T., Jebreen, K., Swaitti, T., Jebreen, M., RADWAN, E. S., Rebai, W. K., Nawajah, I., Shamsti, O., Obeïd, S., et al. (2025) · Conflict and Health · doi:10.1186/s13031-025-00744-3 · Cited by 1
van Os, J. (2014) · Schizophrenia Research · doi:10.1016/s0920-9964(14)70221-x · Cited by 1
Mapping the uncanny : Assessing dimensions of psychotic-like experiences for clinical utility
Therman, S. (2014) · STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) · Cited by 1
Knitting up the ravelled sleeve of care: sleep and psychosis
Birchwood, M. J. (2015) · The Lancet Psychiatry · doi:10.1016/s2215-0366(15)00371-5 · Cited by 1
Dumas, L.-É., Fernandez, A., Auby, P., & Askenazy-Gittard, F. (2024) · PLoS ONE · doi:10.1371/journal.pone.0306338 · Cited by 3
Cullen, C., Gaynor, K., & Kessler, K. (2025) · Schizophrenia Research Cognition · doi:10.1016/j.scog.2025.100357 · Cited by 1
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Smeets, F. (2014) · Research Publications (Maastricht University) · doi:10.26481/dis.20140502fs · Cited by 1
Santiago, Ó. M. (2016) · UVaDOC UVaDOC University of Valladolid Documentary Repository (University of Valladolid) · doi:10.35376/10324/18776 · Cited by 1
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Honings (2017) · Research Publications (Maastricht University) · doi:10.26481/dis.20171222sh · Cited by 1
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Rossum, I. W.-V. (2010) · Research Publications (Maastricht University) · doi:10.26481/dis.20100114ir
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Kuepper, R. (2012) · Research Publications (Maastricht University) · doi:10.26481/dis.20120504rk
Studies of the affective and developmental domains of psychopathology in psychosis
Kaymaz, N. (2011) · Research Publications (Maastricht University) · doi:10.26481/dis.20110622nk
Dael, F. W. J. J. V. (2014) · Research Publications (Maastricht University) · doi:10.26481/dis.20141204fv
Farfán, B., & Marcela, J. (2013) · TDX (Tesis Doctorals en Xarxa)
Experiencias psicóticas e ideación suicida en adolescentes
Romero, M. C. G., Restrepo, M. L., Restrepo, D., & Hincapié, G. M. S. (2021) · Medicina UPB · doi:10.18566/medupb.v40n1.a04
Dumas, L.-É., Askenazy-Gittard, F., & Fernandez, A. (2025) · PLoS ONE · doi:10.1371/journal.pone.0332910
Danyluik, M., Ghanem, J., Bedford, S. A., Aversa, S., Leclercq, A., Ibrahim, F., Proteau-Fortin, F., Eid, J., Morvan, M., Turner, M., et al. (2026) · medRxiv · doi:10.64898/2026.03.04.26347618
Huang, Y., Yang, X., Dong, H.-X., Yan, P., Wang, Y., Zeng, K., & Wang, G. (2026) · BMC Psychiatry · doi:10.1186/s12888-026-07986-2
Fekih‐Romdhane, F., Stambouli, M., Ghrissi, F., Hakiri, A., Loch, A. A., Cheour, M., & Hallit, S. R. (2026) · Nutrire · doi:10.1186/s41110-026-00461-8
Hokayem, C., Haddad, G., Fawaz, M. A., Hallit, R. R., Malaeb, D. N., Obeïd, S., Hallit, S. R., & Fekih‐Romdhane, F. (2026) · International Journal of Social Psychiatry · doi:10.1177/00207640261433235
Wang, Y., Cai, Q., Xu, X., & Gu, J. H. (2026) · Journal of Multidisciplinary Healthcare · doi:10.2147/jmdh.s617713
Feng, Y., Sun, X., Zhang, X., Xue, J., Liu, Z., Chen, C., Wang, J., Geng, F., Li, W., Luo, X., et al. (2026) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-026-02356-1
Metadata
- Authors
- van Rossum, I., Dominguez, M.-D.-G., Lieb, R., Wittchen, H.-U., & van Os, J.
- Affiliations
- Maastricht University Medical Centre (NL)
- University of Basel (CH)
- ORCID
- Lieb, R.
- Venue
- Schizophrenia Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-09-30
- Volume
- 37
- Issue
- 3
- Pages
- 561-571
- ISSN
- 0586-7614 (ISSN-L)
- 1745-1701
- PMC
- PMC3080695
- OpenAlex
- W2097810958
- Cited by
- 170
- References
- 49
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 5 · 2023: 8 · 2022: 7 · 2021: 5 · 2020: 6 · 2019: 10 · 2018: 9 · 2017: 10 · 2016: 15 · 2015: 11 · 2014: 13 · 2013: 20 · 2012: 17
- FWCI
- 8.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Schizophrenia Bulletin (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Qucosa (Saxon State and University Library Dresden) (submittedVersion, other-oa)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Funders
- Eli Lilly and Company
- Pfizer
- AstraZeneca
- Deutsche Forschungsgemeinschaft (WI 709/8-1, WI 709/7-1, WI2246/1‐1, LA1148/1‐1)
- Servier
- H. Lundbeck A/S
- Cilag
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- emotional dysregulation, reality distortion
- MeSH terms
- Adolescent, Affective Symptoms, Bipolar Disorder, Depression, Female, Follow-Up Studies, Germany, Humans, Male, Perceptual Distortion, Prospective Studies, Reality Testing, Risk Factors, Adolescent Development, Young Adult
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