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Cited by 54Schizophrenia research and treatmentCounseling, Therapy, and Family DynamicsFamily Caregiving in Mental Illness

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

Evaluating Genetic Counseling for Individuals With Schizophrenia in the Molecular Age

Open access
Costain, Gregory, Esplen, Mary Jane, Toner, Brenda, Scherer, Stephen W., Meschino, Wendy S., Hodgkinson, Kathleen A., Bassett, Anne S.·2014·Schizophrenia Bulletin
DOI 10.1093/schbul/sbs138PMC PMC3885288
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Abstract

BACKGROUND: Recent advances in schizophrenia genetics are shedding new light on etiopathogenesis, but issues germane to translation of findings into clinical practice are relatively understudied. We assessed the need for, and efficacy of, a contemporary genetic counseling protocol for individuals with schizophrenia. METHODS: After characterizing rare copy number variation in a cohort of adults with schizophrenia, we recruited subjects from the majority of individuals who had no clinically relevant structural genetic variant. We used a pre-post study design with longitudinal follow-up to assess both the profile of need and the impact of general genetic counseling on key knowledge-based and psychological factors. RESULTS: Thirty-nine (60.0%) of 65 patients approached actively expressed an interest in the study. At baseline, participants (n = 25) tended to overestimate the risk of familial recurrence of schizophrenia, express considerable concern related to this perceived risk, endorse myths about schizophrenia etiology, and blame themselves for their illness. Postcounseling, there was a significant improvement in understanding of the empiric recurrence risk (P = .0090), accompanied by a decrease in associated concern (P = .0020). There were also significant gains in subjective (P = .0007) and objective (P = .0103) knowledge, and reductions in internalized stigma (P = .0111) and self-blame (P = .0401). Satisfaction with genetic counseling, including endorsement of the need for such counseling (86.4%), was high. CONCLUSIONS: These results provide initial evidence of need for, and efficacy of, genetic counseling for individuals with schizophrenia. The findings may help facilitate development of a contemporary genetic counseling process that could optimize outcomes in the nascent field of evidence-based psychiatric genetic counseling.

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Crossref · 10.1093/schbul/sbs138

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  • These factors appear to raise or lower vulnerability across many mental disorders.

    “these factors seem to increase or decrease vulnerability to many mental disorders.”

    From Preventive strategies for mental health (2018) · cites this paper as [124]

  • Risk and protective factors do not appear to be confined to separate silos for each current clinical diagnosis.

    “There do not seem to be silos of risk or protective factors for current clinical diagnoses.”

    From Preventive strategies for mental health (2018) · cites this paper as [124]

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Metadata

Authors
Costain, G., Esplen, M. J., Toner, B., Scherer, S. W., Meschino, W. S., Hodgkinson, K. A., & Bassett, A. S.
Affiliations
  • Centre for Addiction and Mental Health (CA)
  • University Health Network (CA)
  • University of Toronto (CA)
  • North York General Hospital (CA)
Corresponding author
Bassett, Anne S.
ORCID
Venue
Schizophrenia Bulletin
Publisher
Oxford University Press (OUP)
Published
2012-12-12
Volume
40
Issue
1
Pages
78-87
ISSN
  • 0586-7614 (ISSN-L)
  • 1745-1701
DOI
10.1093/schbul/sbs138
PMC
PMC3885288
OpenAlex
W2122319697
Cited by
54
References
47
Citations by year
2025: 3 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 8 · 2019: 8 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 4 · 2014: 6 · 2013: 3
FWCI
2.97
Type
journal article
Language
en
Open access
Locations
  • Schizophrenia Bulletin (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Canadian Institutes of Health Research (MOP #111238, MOP-53216)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Psychology › Clinical Psychology › Counseling, Therapy, and Family Dynamics
  • Social Sciences › Psychology › Clinical Psychology › Family Caregiving in Mental Illness
Keywords
genetic counseling, schizophrenia
MeSH terms
Adult, Clinical Protocols, Consumer Behavior, Female, Follow-Up Studies, Genetic Counseling, Genetic Testing, Guilt, Humans, Health Knowledge, Attitudes, Practice, Male, Middle Aged, Recurrence, Schizophrenia, Social Stigma

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