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Ten-Year Follow-up of the OPUS Specialized Early Intervention Trial for Patients With a First Episode of Psychosis
Open accessAbstract
INTRODUCTION: Specialized early intervention programs such as The Danish OPUS treatment are efficient in treating patients with a first episode of psychosis (FEP) at least after 2 and 5 years. Few studies have examined long-term outcomes of these interventions. AIM: To examine the effect of 2 years of OPUS vs treatment as usual (TAU) within an FEP cohort, 10 years after inclusion into the OPUS trial. METHODS: From 1998 to 2000, participants were randomized to OPUS or TAU. Ten years later, we conducted comprehensive interviews and performed register-based follow-up on all participants in national Danish registers. We analyzed participants according to the intention-to-treat principle. RESULTS: Of the 547 participants included in the study, 347 (63.4%) took part in this follow-up. While there was evidence of a differential 10-year course in the development of negative symptoms, psychiatric bed days, and possibly psychotic symptoms in favor of OPUS treatment, differences were driven by effects at earlier follow-ups and had diminished over time. Statistically significant differences in the course of use of supported housing were present even after 8-10 years. There were no differences between OPUS and TAU regarding income, work-related outcomes, or marital status. CONCLUSION: Most of the positive short-term effects of the OPUS intervention had diminished or vanished at this long-term follow-up. We observed a clear tendency that OPUS treatment leads to fewer days in supported housing. There is a need for further studies investigating if extending the intervention will improve outcomes more markedly at long-term follow-ups.
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In the citing paper
“OPUS results at 2 years showed significant positive outcomes compared to services as usual: decreased positive and negative psychotic symptoms”
From Community Interventions to Promote Mental Health and Social Equity (2019) · cites this paper as [50]
In the citing paper
“improved treatment adherence”
From Community Interventions to Promote Mental Health and Social Equity (2019) · cites this paper as [50]
In the citing paper
“higher treatment satisfaction”
From Community Interventions to Promote Mental Health and Social Equity (2019) · cites this paper as [50]
In the citing paper
“reduced substance use”
From Community Interventions to Promote Mental Health and Social Equity (2019) · cites this paper as [50]
In the citing paper
“lower antipsychotic medication dosage”
From Community Interventions to Promote Mental Health and Social Equity (2019) · cites this paper as [50]
In the citing paper
“reduced family burden”
From Community Interventions to Promote Mental Health and Social Equity (2019) · cites this paper as [50]
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“At 10-year follow-up, however, most of these outcome differences had dissipated.”
From Community Interventions to Promote Mental Health and Social Equity (2019) · cites this paper as [50]
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Metadata
- Authors
- Secher, R. G., Hjorthoj, C. R., Austin, S. F., Thorup, A., Jeppesen, P., Mors, O., & Nordentoft, M.
- Affiliations
- Copenhagen University Hospital (DK)
- Glostrup Hospital (DK)
- Aarhus University Hospital (DK)
- Venue
- Schizophrenia Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-11-07
- Volume
- 41
- Issue
- 3
- Pages
- 617-626
- ISSN
- 0586-7614 (ISSN-L)
- 1745-1701
- PMC
- PMC4393691
- OpenAlex
- W2101562237
- Cited by
- 158
- References
- 33
- Citations by year
- 2026: 12 · 2025: 5 · 2024: 8 · 2023: 19 · 2022: 20 · 2021: 14 · 2020: 17 · 2019: 21 · 2018: 21 · 2017: 11 · 2016: 6 · 2015: 3
- FWCI
- 5.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Schizophrenia Bulletin (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
- Funders
- Lundbeckfonden (R155-2014-1724)
- Danmarks Frie Forskningsfond
- Region Hovedstaden
- Ministeriet Sundhed Forebyggelse (96-0770-71)
- TrygFonden
- Region Midtjylland
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Clinical Psychology › Psychiatric care and mental health services
- Social Sciences › Psychology › Clinical Psychology › Counseling, Therapy, and Family Dynamics
- Keywords
- first-episode psychosis
- MeSH terms
- Adult, Community Mental Health Services, Denmark, Female, Follow-Up Studies, Humans, Male, Middle Aged, Psychotic Disorders, Registries, Schizophrenia, Time Factors, Outcome Assessment, Health Care, Early Medical Intervention
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