Ten-Year Follow-up of the OPUS Specialized Early Intervention Trial for Patients With a First Episode of Psychosis

Secher, R. G.; Hjorthoj, C. R.; Austin, S. F.; Thorup, A.; Jeppesen, P.; Mors, O.; Nordentoft, M.

doi:10.1093/schbul/sbu155

Cited by 158Schizophrenia research and treatmentPsychiatric care and mental health servicesCounseling, Therapy, and Family Dynamics

Ten-Year Follow-up of the OPUS Specialized Early Intervention Trial for Patients With a First Episode of Psychosis

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Secher, R. G., Hjorthoj, C. R., Austin, S. F., Thorup, A., Jeppesen, P., Mors, O., Nordentoft, M.·2015·Schizophrenia Bulletin

DOI 10.1093/schbul/sbu155PMC PMC4393691

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Abstract

INTRODUCTION: Specialized early intervention programs such as The Danish OPUS treatment are efficient in treating patients with a first episode of psychosis (FEP) at least after 2 and 5 years. Few studies have examined long-term outcomes of these interventions. AIM: To examine the effect of 2 years of OPUS vs treatment as usual (TAU) within an FEP cohort, 10 years after inclusion into the OPUS trial. METHODS: From 1998 to 2000, participants were randomized to OPUS or TAU. Ten years later, we conducted comprehensive interviews and performed register-based follow-up on all participants in national Danish registers. We analyzed participants according to the intention-to-treat principle. RESULTS: Of the 547 participants included in the study, 347 (63.4%) took part in this follow-up. While there was evidence of a differential 10-year course in the development of negative symptoms, psychiatric bed days, and possibly psychotic symptoms in favor of OPUS treatment, differences were driven by effects at earlier follow-ups and had diminished over time. Statistically significant differences in the course of use of supported housing were present even after 8-10 years. There were no differences between OPUS and TAU regarding income, work-related outcomes, or marital status. CONCLUSION: Most of the positive short-term effects of the OPUS intervention had diminished or vanished at this long-term follow-up. We observed a clear tendency that OPUS treatment leads to fewer days in supported housing. There is a need for further studies investigating if extending the intervention will improve outcomes more markedly at long-term follow-ups.

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In the Danish OPUS trial, at 2 years, ACT-based assertive early intervention compared to services as usual decreased positive and negative psychotic symptoms.
“OPUS results at 2 years showed significant positive outcomes compared to services as usual: decreased positive and negative psychotic symptoms”
From Community Interventions to Promote Mental Health and Social Equity (2019) · cites this paper as [50]
In OPUS, at 2 years, ACT-based early intervention improved treatment adherence compared to services as usual.
“improved treatment adherence”
From Community Interventions to Promote Mental Health and Social Equity (2019) · cites this paper as [50]
In OPUS, at 2 years, ACT-based early intervention increased treatment satisfaction compared to services as usual.
“higher treatment satisfaction”
From Community Interventions to Promote Mental Health and Social Equity (2019) · cites this paper as [50]
In OPUS, at 2 years, ACT-based early intervention reduced substance use compared to services as usual.
“reduced substance use”
From Community Interventions to Promote Mental Health and Social Equity (2019) · cites this paper as [50]
In OPUS, at 2 years, ACT-based early intervention lowered antipsychotic medication dosage compared to services as usual.
“lower antipsychotic medication dosage”
From Community Interventions to Promote Mental Health and Social Equity (2019) · cites this paper as [50]

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S25-02 - Preventive and Intensive Treatment of Psychosis for High-Risk and First-Episode Subjects
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Self-citation

Authors: Secher, R. G., Hjorthoj, C. R., Austin, S. F., Thorup, A., Jeppesen, P., Mors, O., & Nordentoft, M.
Affiliations: Copenhagen University Hospital (DK)
Glostrup Hospital (DK)
Aarhus University Hospital (DK)
ORCID: Austin, S. F.
Thorup, A.
Jeppesen, P.
Mors, O.
Nordentoft, M.
Venue: Schizophrenia Bulletin
Publisher: Oxford University Press (OUP)
Published: 2014-11-07
Volume: 41
Issue: 3
Pages: 617-626
ISSN: 0586-7614 (ISSN-L)
1745-1701
DOI: 10.1093/schbul/sbu155
PMC: PMC4393691
OpenAlex: W2101562237
Cited by: 158
References: 33
Citations by year: 2026: 12 · 2025: 5 · 2024: 8 · 2023: 19 · 2022: 20 · 2021: 14 · 2020: 17 · 2019: 21 · 2018: 21 · 2017: 11 · 2016: 6 · 2015: 3
FWCI: 5.09
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Schizophrenia Bulletin (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
Funders: Lundbeckfonden (R155-2014-1724)
Danmarks Frie Forskningsfond
Region Hovedstaden
Ministeriet Sundhed Forebyggelse (96-0770-71)
TrygFonden
Region Midtjylland
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Social Sciences › Psychology › Clinical Psychology › Psychiatric care and mental health services
Social Sciences › Psychology › Clinical Psychology › Counseling, Therapy, and Family Dynamics
Keywords: first-episode psychosis
MeSH terms: Adult, Community Mental Health Services, Denmark, Female, Follow-Up Studies, Humans, Male, Middle Aged, Psychotic Disorders, Registries, Schizophrenia, Time Factors, Outcome Assessment, Health Care, Early Medical Intervention

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Ten-Year Follow-up of the OPUS Specialized Early Intervention Trial for Patients With a First Episode of Psychosis

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