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Motor Abnormalities: From Neurodevelopmental to Neurodegenerative Through “Functional” (Neuro)Psychiatric Disorders
Open accessAbstract
Background: Motor abnormalities (MAs) of severe mental disorders have been traditionally neglected both in clinical practice and research, although they are an increasing focus of attention because of their clinical and neurobiological relevance. For historical reasons, most of the literature on MAs has been focused to a great extent on schizophrenia, and as a consequence their prevalence and featural properties in other psychiatric or neuropsychiatric disorders are poorly known. In this article, we evaluated the extent to which catatonic, extrapyramidal and neurological soft signs, and their associated clinical features, are present transdiagnostically. Methods: We examined motor-related features in neurodevelopmental (schizophrenia, obsessive compulsive disorder, autism spectrum disorders), "functional" (nonschizophrenic nonaffective psychoses, mood disorders) and neurodegenerative (Alzheimer's disease) disorders. Examination of the literature revealed that there have been very few comparisons of motor-related features across diagnoses and we had to rely mainly in disorder-specific studies to compare it transdiagnostically. Results: One or more motor domains had a substantial prevalence in all the diagnoses examined. In "functional" disorders, MAs, and particularly catatonic signs, appear to be markers of episode severity; in chronic disorders, although with different degree of strength or evidence, all motor domains are indicators of both disorder severity and poor outcome; lastly, in Alzheimer's disease they are also indicators of disorder progression. Conclusions: MAs appear to represent a true transdiagnostic domain putatively sharing neurobiological mechanisms of neurodevelopmental, functional or neurodegenerative origin.
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“The National Institute for Mental Health (NIMH), in its Research Domain Criteria (RDoC) framework matrix [76 -79], has recently proposed the incorporation of a new Sensorimotor Systems domain, composed of sub constructs such as Motor Actions, Agency and Ownership and Habits [80 -82]”
From Habit as a therapeutic component in psychological treatment for obsessive-compulsive disorder: A randomised controlled feasibility study. (2026) · cites this paper as [82]
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Metadata
- Authors
- Peralta, V., & Cuesta, M. J.
- Affiliations
- Complejo Hospitalario de Navarra (ES)
- ORCID
- Cuesta, Manuel J
- Venue
- Schizophrenia Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-07-22
- Volume
- 43
- Issue
- 5
- Pages
- 956-971
- ISSN
- 0586-7614 (ISSN-L)
- 1745-1701
- PMC
- PMC5581892
- OpenAlex
- W2737738292
- Cited by
- 133
- References
- 251
- Citations by year
- 2026: 8 · 2025: 22 · 2024: 5 · 2023: 11 · 2022: 16 · 2021: 20 · 2020: 21 · 2019: 8 · 2018: 13 · 2017: 9
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Schizophrenia Bulletin (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Instituto de Salud Carlos III (PI16/02148)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Keywords
- motor abnormalities, transdiagnostic markers
- MeSH terms
- Autism Spectrum Disorder, Alzheimer Disease, Humans, Movement Disorders, Obsessive-Compulsive Disorder, Psychotic Disorders, Schizophrenia, Mood Disorders
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