The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Augmentation of the Restless Legs Syndrome With Carbidopa/Levodopa
Abstract
Dopaminergic agents and carbidopa/levodopa have become the preferred treatment for both the restless legs (RL) syndrome and for periodic limb movements in sleep (PLMS). For once-nightly treatments with carbidopa/ levodopa, a problem with morning end-of-dose rebound increases in leg movements has been reported to occur in the about one-fourth of the patients. In our clinical studies a previously unreported but far more significant problem of markedly augmented RL symptoms occurred in the afternoon and the evening prior to taking the next nightly dose. A systematic prospective evaluation of this augmentation in 46 consecutive patients treated with carbidopa/ levodopa for RL syndrome or PLMS disorder found this augmentation to be the major adverse effect of treatment. Augmentation occurred for 31% of PLMS patients and 82% of all RL patients. It was greater for subjects with more severe RL symptoms and for patients on higher doses (> or = 50/200 mg carbidopa/levodopa) but was unrelated to gender, age or baseline severity of PLMS. This augmentation was severe enough to require medication change for 50% of the RL patients and 13% of PLMS patients. Augmentation resolved with cessation of the medication and could be minimized by keeping the dose low.
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Citations
Cites
The International Classification of Sleep Disorders: Diagnostic and Coding Manual
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Periodic movements in sleep (nocturnal myoclonus): Relation to sleep disorders
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Self-citationA double‐blind randomized crossover trial of bromocriptine and placebo in restless legs syndrome
Walters, A. S., Hening, W. A., Kavey, N., Chokroverty, S., & Gidro‐Frank, S. (1988) · Annals of Neurology · doi:10.1002/ana.410240318 · Cited by 175
Restless Legs Syndrome Treatment with Dopaminergic Drugs
Akpinar, L. (1987) · Clinical Neuropharmacology · doi:10.1097/00002826-198702000-00007 · Cited by 136
Effects of lisuride and LSD on cerebral monoamine systems and hallucinosis
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Dopaminergic treatment of restless legs and rebound phenomenon
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Cited by
Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology
Allen, R. P., Picchietti, D., Hening, W. A., Trenkwalder, C., Walters, A. S., & Montplaisi, J. (2003) · Sleep Medicine · doi:10.1016/s1389-9457(03)00010-8 · Cited by 2,900
Self-citationMRI measurement of brain iron in patients with restless legs syndrome
Allen, R. P., Barker, P. B., Wehrl, F., Song, H. K., & Earley, C. J. (2001) · Neurology · doi:10.1212/wnl.56.2.263 · Cited by 570
Self-citationRestless legs syndrome: pathophysiology, clinical presentation and management
Trenkwalder, C., & Paulus, W. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.55 · Cited by 310
An Algorithm for the Management of Restless Legs Syndrome
Silber, M. H., Ehrenberg, B. L., Allen, R. P., Buchfuhrer, M. J., Earley, C. J., Hening, W. A., & Rye, D. B. (2004) · Mayo Clinic Proceedings · doi:10.4065/79.7.916 · Cited by 300
Self-citationPeriodic limb movements in sleep: State-dependent excitability of the spinal flexor reflex
Bara-Jimenez, W., Aksu, M., Graham, B., Sato, S., & Hallett, M. (2000) · Neurology · doi:10.1212/wnl.54.8.1609 · Cited by 269
Metadata
- Authors
- Allen, R. P., & Earley, C. J.
- Venue
- Sleep
- Publisher
- Oxford University Press (OUP)
- Published
- 1996-04
- Volume
- 19
- Issue
- 3
- Pages
- 205-213
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- OpenAlex
- W83552848
- Cited by
- 451
- References
- 13
- FWCI
- 8.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Allen, R. P., & Earley, C. J. (1996). Augmentation of the Restless Legs Syndrome With Carbidopa/Levodopa. Sleep. https://doi.org/10.1093/sleep/19.3.205
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
